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The 3 SRCR Repeats and their disease

S.NO	Uniprot ID	Protein Name	Sequence Length	SRCR Repeats region	Disease
1	Q9UGM3	Deleted in malignant brain tumors 1 protein	2413	DOMAIN 102 202 SRCR 1 DOMAIN 234 334 SRCR 2 DOMAIN 363 463 SRCR 3 DOMAIN 494 594 SRCR 4 DOMAIN 602 702 SRCR 5 DOMAIN 733 833 SRCR 6 DOMAIN 862 962 SRCR 7 DOMAIN 993 1093 SRCR 8 DOMAIN 1122 1222 SRCR 9 DOMAIN 1251 1351 SRCR 10 DOMAIN 1380 1480 SRCR 11 DOMAIN 1509 1609 SRCR 12 DOMAIN 1640 1740 SRCR 13 DOMAIN 1883 1986 SRCR 14	"DISEASE: Glioma (GLM) [MIM:137800]: Gliomas are benign or malignant central nervous system neoplasms derived from glial cells. They comprise astrocytomas and glioblastoma multiforme that are derived from astrocytes, oligodendrogliomas derived from oligodendrocytes and ependymomas derived from ependymocytes. Note=The gene represented in this entry is involved in disease pathogenesis. Homozygous deletions may be the predominant mechanism of DMBT1 inactivation playing a role in carcinogenesis. DMBT1 is deleted in medulloblastoma and glioblastoma cell lines; point mutations have also been reported in patients with glioma. A loss or reduction of DMBT1 expression has been seen in esophageal, gastric, lung and colorectal carcinomas as well".
2	P58215	Lysyl oxidase homolog 3	753	DOMAIN 44 145 SRCR 1 DOMAIN 169 282 SRCR 2 DOMAIN 307 407 SRCR 3 DOMAIN 417 525 SRCR 4	"DISEASE: Note=Defects in LOXL3 are found in a family with an autosomal recessive form of Stickler syndrome, an inherited disorder that associates ocular signs with more or less complete forms of Pierre Robin sequence and sensorineural deafness (PubMed:25663169). Pierre Robin sequence includes an opening in the roof of the mouth (a cleft palate) (PubMed:25663169). The degree of hearing loss varies among affected individuals and may become more severe over time (PubMed:25663169). Syndrome expressivity is variable (PubMed:25663169). Ocular disorders include non-progressive myopia with associated chorioretinal degeneration (PubMed:25663169). Defects in LOXL3 are found in another family with early-onset high myopia (PubMed:26957899). The disease may be caused by mutations affecting the gene represented in this entry (PubMed:25663169, PubMed:26957899)".
3	P56730	Neurotrypsin	875	DOMAIN 170 271 SRCR 1 DOMAIN 280 381 SRCR 2 DOMAIN 387 487 SRCR 3 DOMAIN 500 601 SRCR 4	"DISEASE: Mental retardation, autosomal recessive 1 (MRT1) [MIM:249500]: A disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period. Non-syndromic mental retardation patients do not manifest other clinical signs. Note=The disease is caused by mutations affecting the gene represented in this entry".