S.NO	Uniprot ID	Protein Name	Sequence Length	C2 Region	Mutation	Involvement of Repeats in Mutations
1	Q9HCH5	Synaptotagmin-like protein 2	934	629 733 DOMAIN 629 733 C2 1 778 880 DOMAIN 778 880 C2 2	11 11 E->A: Abolishes interaction with RAB27A 32 32 R->A: Abolishes interaction with RAB27A	N
2	Q9NZM1	Myoferlin	2061	1 85 DOMAIN 1 85 C2 1 186 281 DOMAIN 186 281 C2 2 345 458 DOMAIN 345 458 C2 3 1126 1231 DOMAIN 1126 1231 C2 4 1538 1638 DOMAIN 1538 1638 C2 5	238 240 238 240 NPF->SPL: Reduces interaction with EHD2	Y
3	O75923	Dysferlin	2080	1 85 DOMAIN 1 85 C2 1 207 302 DOMAIN 207 302 C2 2 366 479 DOMAIN 366 479 C2 3 1139 1244 DOMAIN 1139 1244 C2 4 1336 1423 DOMAIN 1336 1423 C2 5 1565 1663 DOMAIN 1565 1663 C2 6 1813 1926 DOMAIN 1813 1926 C2 7	16 16 D->A: Fails to bind calcium 21 21 D->A: Fails to bind calcium 71 71 D->A: Fails to bind calcium 79 79 R->D: Moderately increased calcium affinity 80 80 F->A: Reduced calcium affinity	Y
4	Q14644	Ras GTPase-activating protein 3	834	1 96 DOMAIN 1 96 C2 1 132 247 DOMAIN 132 247 C2 2	599 599 K->Q: No binding to IP4 and loss of plasma membrane localization 600 600 K->Q: No binding to IP4 and loss of plasma membrane localization 601 601 R->Q: No binding to IP4 and loss of plasma membrane localization	N
5	Q99829	Copine-1	537	1 98 DOMAIN 1 98 C2 1 144 228 DOMAIN 144 228 C2 2	21 21 D->A: Inhibits translocation to the cell membrane in a calcium-dependent manner and does not inhibit neuronal progenitor cell differentiation when associated with A-90 90 90 D->A: Inhibits translocation to the cell membrane in a calcium-dependent manner and does not inhibit neuronal progenitor cell differentiation when associated with A-21 216 216 D->A: Inhibits translocation to the cell membrane in a calcium-dependent manner and does not inhibit neuronal progenitor cell differentiation when associated with A-222 222 222 D->A: Inhibits translocation to the cell membrane in a calcium-dependent manner and does not inhibit neuronal progenitor cell differentiation when associated with A-216	Y
6	O00445	Synaptotagmin-5	386	124 211 DOMAIN 124 211 C2 1 253 344 DOMAIN 253 344 C2 2	202 202 S->G: Does not affect Ca(2+) affinity as measured by isothermal titration calorimetry of the mutant protein	Y
7	Q9BSJ8	Extended synaptotagmin-1	1104	316 417 DOMAIN 316 417 C2 1 465 558 DOMAIN 465 558 C2 2 634 735 DOMAIN 634 735 C2 3 785 877 DOMAIN 785 877 C2 4 972 1077 DOMAIN 972 1077 C2 5	406 406 D->A: No effect on translocation to sites of contact between the endoplasmic reticulum and the cell membrane 663 663 D->A: Abolishes location at the cell membrane when associated with A-675 and 722-A--A-729 675 675 D->A: Abolishes location at the cell membrane when associated with A-675 and 722-A--A-729 722 729 722 729 DKDLDKDD->AKALAKAA: Abolishes location at the cell membrane when associated with A-663 and A-675 724 724 D->A: Loss of translocation to sites of contact between the endoplasmic reticulum and the cell membrane	Y
8	A0FGR8	Extended synaptotagmin-2	921	372 473 DOMAIN 372 473 C2 1 523 617 DOMAIN 523 617 C2 2 788 892 DOMAIN 788 892 C2 3	401 401 D->A: Abolishes calcium binding when associated with A-413 413 413 D->A: Abolishes calcium binding when associated with A-401 413 413 D->N: Strongly reduces calcium binding 466 466 D->A: Impairs binding of the third calcium ion, but has no effect on the binding of the other two calcium ions 833 840 833 840 KRRSGRRK->AAASGAAA: Abolishes location at the cell membrane	Y
9	Q86UR5	Regulating synaptic membrane exocytosis protein 1	1692	744 850 DOMAIN 744 850 C2 1 1538 1640 DOMAIN 1538 1640 C2 2	796 797 796 797 RR->AA: Abolishes interaction with SYT1 and CACNA1B 1591 1592 1591 1592 KK->AA: Abolishes interaction with SYT1 and CACNA1B	Y
10	Q70J99	Protein unc-13 homolog D	1090	98 221 DOMAIN 98 221 C2 1 912 1019 DOMAIN 912 1019 C2 2	608 611 608 611 Missing: Abolishes localization to lysosomes and interaction with RAB27A	N

The 10 C2 Repeats and their Mutations