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The 5 Cadherin Repeats and their Mutations

S.NO	Uniprot ID	Protein Name	Sequence Length	Cadherin Region	Mutation	Involvement of Repeats in Mutations
1	P12830	Cadherin-1	882	155 262 DOMAIN 155 262 Cadherin 1 263 375 DOMAIN 263 375 Cadherin 2 376 486 DOMAIN 376 486 Cadherin 3 487 593 DOMAIN 487 593 Cadherin 4 594 697 DOMAIN 594 697 Cadherin 5	637 637 N->Q: CDH1 becomes a substrate for ERAD and is retro-translocated from ER to cytoplasm 754 754 Y->F: Abolishes binding to CBLL1 759 761 759 761 GGG->AAA: Binds to CTNNB1 but abolishes interaction of CTNNB1 with PSEN1	Y
2	Q9BYE9	Cadherin-related family member 2	1310	27 124 DOMAIN 27 124 Cadherin 1 125 241 DOMAIN 125 241 Cadherin 2 242 353 DOMAIN 242 353 Cadherin 3 368 480 DOMAIN 368 480 Cadherin 4 481 586 DOMAIN 481 586 Cadherin 5 586 695 DOMAIN 586 695 Cadherin 6 696 808 DOMAIN 696 808 Cadherin 7 810 928 DOMAIN 810 928 Cadherin 8 930 1058 DOMAIN 930 1058 Cadherin 9	1310 1310 L->R: Loss of interaction with USH1C	N
3	O94985	Calsyntenin-1	981	38 164 DOMAIN 38 164 Cadherin 1 165 265 DOMAIN 165 265 Cadherin 2	913 914 913 914 NP->AA: Abolishes interaction with APBA2 918 918 Y->A: No effect on APBA2-binding	N
4	P55291	Cadherin-15	814	61 152 DOMAIN 61 152 Cadherin 1 153 260 DOMAIN 153 260 Cadherin 2 261 375 DOMAIN 261 375 Cadherin 3 376 481 DOMAIN 376 481 Cadherin 4 482 590 DOMAIN 482 590 Cadherin 5	103 103 K->R: No effect on cell-cell adhesion 109 109 M->T: No effect on cell-cell adhesion	Y
5	Q9HBB8	Cadherin-related family member 5	845	71 124 DOMAIN 71 124 Cadherin 1 125 237 DOMAIN 125 237 Cadherin 2 249 354 DOMAIN 249 354 Cadherin 3 355 459 DOMAIN 355 459 Cadherin 4	109 109 R->G: Loss of binding to CDHR2 845 845 I->R: Loss of interaction with USH1C	Y