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The 2 DH Repeats and their Mutations

S.NOUniprot IDProtein Name Sequence LengthDH RegionMutationInvolvement of Repeats in Mutations
1 O60229 Kalirin 29852712 2712 K->A: Loss of autophosphorylation
N
2 O75962 Triple functional domain protein 30971299 1299 E->A: 50% decrease in nucleotide exchange activity
1303 1303 T->A: 40% decrease in nucleotide exchange activity
1389 1389 N->A: No change in nucleotide exchange activity
1426 1426 V->A: 90% decrease in nucleotide exchange activity
1427 1427 Q->A: 80% decrease in nucleotide exchange activity
1428 1428 R->A: 80% decrease in nucleotide exchange activity
1430 1430 T->A: 80% decrease in nucleotide exchange activity
1431 1431 K->A: Loss of nucleotide exchange activity
1434 1434 L->A: 40% decrease in nucleotide exchange activity
1437 1437 K->A: No change in nucleotide exchange activity
1438 1438 E->A: 30% decrease in nucleotide exchange activity
Y