| S.NO | Uniprot ID | Protein Name | Sequence Length | Macro Region | Mutation | Involvement of Repeats in Mutations |
| 1 | Q8IXQ6 | Poly [ADP-ribose] polymerase 9 | 854 | 147 147 G->E: Reduces the binding to poly(ADP-ribose) by 50 percent and prevents increase in DTX3L-mediated histone ubiquitination without affecting ubiquitin ADP ribosylation, interaction with DTX3L and STAT1 and DTX3L catalytic activity when associated with E-346 346 346 G->E: Reduces the binding to poly(ADP-ribose) by 50 percent and prevents increase in DTX3L-mediated histone ubiquitination without affecting ubiquitin ADP ribosylation, interaction with DTX3L and STAT1 and DTX3L catalytic activity when associated with E-147 719 722 719 722 Missing: Loss of ADP ribosylation activity and interaction with DTX3L 737 737 Y->A: No defect in ubiquitin ADP ribosylation and the interaction with DTX3L 738 738 F->K: Severe reduction in ubiquitin ADP ribosylation 766 769 766 769 Missing: Loss of ADP ribosylation activity and interaction with DTX3L 780 784 780 784 Missing: Reduces ADP ribosylation activity and interaction with DTX3L 802 803 802 803 PE->AA: No defect in ADP ribosylation and interaction with DTX3L 831 854 831 854 Missing: No defect in ADP ribosylation and interaction with DTX3L | Y | |
| 2 | Q460N3 | Poly [ADP-ribose] polymerase 15 | 678 | 559 559 H->Y: Abolishes catalytic activity 560 560 G->A: Slightly reduces catalytic activity when associated with Y-559 and C-604 604 604 Y->C: Reduces catalytic activity 20-fold when associated with Y-559 and A-560 | N | |
| 3 | Q460N5 | Poly [ADP-ribose] polymerase 14 | 1801 | 1055 1055 G->E: Abolishes interaction with PARP10 | Y |