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The 2 PKD Repeats and their Mutations

S.NO	Uniprot ID	Protein Name	Sequence Length	PKD Region	Mutation	Involvement of Repeats in Mutations
1	Q5VV43	Dyslexia-associated protein KIAA0319	1072	341 427 DOMAIN 341 427 PKD 1 435 524 DOMAIN 435 524 PKD 2 530 620 DOMAIN 530 620 PKD 3 621 714 DOMAIN 621 714 PKD 4 720 811 DOMAIN 720 811 PKD 5	995 995 Y->A: Loss of interaction with AP2M1 and impaired endocytosis	N
2	P98161	Polycystin-1	4303	272 359 DOMAIN 272 359 PKD 1 743 817 DOMAIN 743 817 PKD 2 855 928 DOMAIN 855 928 PKD 3 935 1020 DOMAIN 935 1020 PKD 4 1023 1129 DOMAIN 1023 1129 PKD 5 1127 1215 DOMAIN 1127 1215 PKD 6 1213 1298 DOMAIN 1213 1298 PKD 7 1294 1383 DOMAIN 1294 1383 PKD 8 1382 1469 DOMAIN 1382 1469 PKD 9 1468 1551 DOMAIN 1468 1551 PKD 10 1550 1635 DOMAIN 1550 1635 PKD 11 1634 1721 DOMAIN 1634 1721 PKD 12 1719 1805 DOMAIN 1719 1805 PKD 13 1807 1890 DOMAIN 1807 1890 PKD 14 1889 1974 DOMAIN 1889 1974 PKD 15 1977 2057 DOMAIN 1977 2057 PKD 16 2060 2148 DOMAIN 2060 2148 PKD 17	3049 3049 T->C,S: Does not affect auto-cleavage 3049 3049 T->G,R,V: Does not undergo auto-cleavage	N