| S.NO | Uniprot ID | Protein Name | Sequence Length | POLO box Region | Mutation | Involvement of Repeats in Mutations |
| 1 | P53350 | Serine/threonine-protein kinase PLK1 | 603 | 67 67 C->V: In analog-sensitive mutant enlarged catalytic pocket to accommodate purine analogs when associated with G-130 82 82 K->M: Loss of kinase activity 82 82 K->R: Loss of kinase activity 130 130 L->G: In analog-sensitive mutant enlarged catalytic pocket to accommodate purine analogs when associated with V-67 137 137 S->A: No change in activity when associated with D-210 137 137 S->D: Increases activity 176 176 D->N: Abolishes kinase activity 194 194 D->A: Does not interfere with FRY-binding 210 210 T->A: Abolishes activity 210 210 T->D: Increases activity and restores recovery after DNA damage checkpoint 210 210 T->V: Reduced catalytic activity, but no effect on affinity for ATP 337 337 R->A: Interferes with ubiquitination and subsequent proteasomal degradation in anaphase when associated with A-340 340 340 L->A: Interferes with ubiquitination and subsequent proteasomal degradation in anaphase when associated with A-337 414 414 W->F: Abolishes interaction with CDC25C and reduces centrosomal localization 414 414 W->F: No effect on centrosomal localization, nor on S-phase progression when asscociated with A-427 when associated with A- 415 and A-427 415 415 V->A: Loss of centrosomal localization and of S-phase progression when associated with A- 414 and A-427 427 427 L->A: No effect on centrosomal localization, nor on S-phase progression when associated with A-414 when associated with A- 414 and A-415 492 492 K->R: Severe mitotic defects leading to prometaphase delay 538 538 H->A: In pincer mutant loss of centrosomal location and decreased interaction with phosphorylated CDC25C and BUB1 when associated with M-540 540 540 K->M: In pincer mutant loss of centrosomal location and decreased interaction with phosphorylated CDC25C and BUB1 when associated with A-538 | Y | |
| 2 | Q9H4B4 | Serine/threonine-protein kinase PLK3 | 646 | 91 91 K->R: Kinase defective mutant, abolishes activity 203 203 D->A: Kinase defective mutant, abolishes activity 219 219 T->E: Kinase-defective mutant 467 468 467 468 WV->FA: Abolishes localization to the centrosome and ability to induce the G2/M arrest | N | |
| 3 | Q9NYY3 | Serine/threonine-protein kinase PLK2 | 685 | 210 210 N->A: Loss of kinase activity 503 503 W->F: Impairs localization to the centrosome and centriole duplication when associated with A-629 and M-631 629 629 H->A: Impairs localization to the centrosome and centriole duplication when associated with F-503 and M-631 631 631 K->M: Impairs localization to the centrosome and centriole duplication when associated with F-503 and A-631 | Y |