| S.NO | Uniprot ID | Protein Name | Sequence Length | RNase III Region | Mutation | Involvement of Repeats in Mutations |
| 1 | Q9UPY3 | Endoribonuclease Dicer | 1922 | 960 960 F->A: 2-fold decrease in activity 971 971 Y->A: 10-fold decrease in activity when associated with Y-972 972 972 Y->A: 10-fold decrease in activity when associated with Y-971 1036 1036 E->A: 5-fold decrease in activity 1313 1313 E->A: No effect on activity 1320 1320 D->A: Decreased activity when associated with D-1709 1340 1340 E->A: No effect on activity 1444 1444 E->A: Decreased activity when associated with E-1813 1702 1702 Q->A: No effect on activity 1709 1709 D->A: Decreased activity when associated with D-1320 1729 1729 P->E: No effect on activity 1813 1813 E->A: Decreased activity when associated with E-1444 | Y | |
| 2 | Q9NRR4 | Ribonuclease 3 | 1374 | 536 536 C->A: Impairs protein folding and stability when associated with A-538 538 538 C->A: Impairs protein folding and stability when associated with A-536 561 561 C->A: Impairs protein folding and stability 622 623 622 623 RF->AA: Abolishes RNase activity 676 676 C->A: Impairs protein folding and stability 835 836 835 836 RR->AA: Abolishes RNase activity 914 914 R->M: Impairs RNase activity 923 923 R->A: Abolishes RNase activity when associated with A-927 927 927 Y->A: Abolishes RNase activity when associated with A-923 938 940 938 940 RKK->QQQ: Abolishes RNase activity 993 993 E->A,Q: No effect on pri-miRNA processing activity 1045 1045 E->Q: Impairs pri-miRNA processing activity when associated with Q-1222 1077 1077 V->E: Loss of one DGCR8 interaction site no effect on the second DGCR8 interaction site 1171 1171 E->A,Q: No effect on pri-miRNA processing activity 1194 1194 L->R: Abolishes interaction with DGCR8 1222 1222 E->Q: Impairs pri-miRNA processing activity when associated with Q-1045 1243 1243 V->D: Abolishes interaction with DGCR8 | Y |