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The 5 SRCR Repeats and their Mutations

S.NOUniprot IDProtein Name Sequence LengthSRCR RegionMutationInvolvement of Repeats in Mutations
1 O43866 CD5 antigen-like 347123 123 S->A: No effect
when associated with 129-A--A-132
129 132 129 132 SSFS->AAFA: No effect
when associated with A-123
Y
2 P58215 Lysyl oxidase homolog 3 75383 83 C->A: Impaired ability to mediate deacetylation of STAT3
when associated with A-214
A-345 and A-459
214 214 C->A: Impaired ability to mediate deacetylation of STAT3
when associated with A-83
A-345 and A-459
345 345 C->A: Impaired ability to mediate deacetylation of STAT3
when associated with A-83
A-214 and A-459
376 376 C->A: Impaired ability to mediate deacetylation of STAT3
when associated with A-446 and A-492
446 446 C->A: Impaired ability to mediate deacetylation of STAT3
when associated with A-376 and A-492
459 459 C->A: Impaired ability to mediate deacetylation of STAT3
when associated with A-83
A-214 and A-345
492 492 C->A: Impaired ability to mediate deacetylation of STAT3
when associated with A-376 and A-446
607 609 607 609 HGH->QGQ: Impaired ability to mediate deacetylation of STAT3
Y
3 P30203 T-cell differentiation antigen CD6 668291 291 D->A: Strongly reduces interaction with ALCAM
293 293 E->A: Reduces interaction with ALCAM
295 295 Y->A: Abolishes interaction with ALCAM
298 298 E->A: Nearly abolishes interaction with ALCAM
314 314 R->A: Reduces interaction with ALCAM
327 327 Y->A: Nearly abolishes interaction with ALCAM
329 329 S->A: Reduces interaction with ALCAM
346 346 N->A: Strongly reduces interaction with ALCAM
349 349 L->A: Reduces interaction with ALCAM
352 352 Q->A: Reduces interaction with ALCAM
353 353 S->A: Reduces interaction with ALCAM
662 662 Y->F: Reduces tyrosine phosphorylation
Y
4 Q86VB7 Scavenger receptor cysteine-rich type 1 protein M130 11561072 1072 T->A: Impaired phosphorylation by PRKCA
1084 1084 S->A: Impaired phosphorylation by PRKCA
1096 1096 Y->A: Massive decrease of endocytotic activity
N
5 Q9Y4K0 Lysyl oxidase homolog 2 774455 455 N->Q: Inhibits secretion
626 628 626 628 HRH->ARA: Abolishes oxidase activity and oxidation of trimethylated 'Lys-4' of histone H3 but does not affect secretion, interaction with SNAI1, binding to the CDH1 promoter, repression of CDH1 transcription or ability to induce EMT
626 626 H->A: Loss of enzyme activity
628 628 H->A: Loss of enzyme activity
630 630 H->A: Loss of enzyme activity
644 644 N->Q: Inhibits secretion
653 653 K->A: Loss of enzyme activity
689 689 Y->A: Loss of enzyme activity
689 689 Y->F: Does not affect ability to inhibit keratinocyte differentiation
Y