S.NO | Uniprot ID | Protein Name | Sequence Length | SRCR Region | Mutation | Involvement of Repeats in Mutations |
1 | O43866 | CD5 antigen-like | 347 | 123 123 S->A: No effect when associated with 129-A--A-132 129 132 129 132 SSFS->AAFA: No effect when associated with A-123 | Y | |
2 | P58215 | Lysyl oxidase homolog 3 | 753 | 83 83 C->A: Impaired ability to mediate deacetylation of STAT3 when associated with A-214 A-345 and A-459 214 214 C->A: Impaired ability to mediate deacetylation of STAT3 when associated with A-83 A-345 and A-459 345 345 C->A: Impaired ability to mediate deacetylation of STAT3 when associated with A-83 A-214 and A-459 376 376 C->A: Impaired ability to mediate deacetylation of STAT3 when associated with A-446 and A-492 446 446 C->A: Impaired ability to mediate deacetylation of STAT3 when associated with A-376 and A-492 459 459 C->A: Impaired ability to mediate deacetylation of STAT3 when associated with A-83 A-214 and A-345 492 492 C->A: Impaired ability to mediate deacetylation of STAT3 when associated with A-376 and A-446 607 609 607 609 HGH->QGQ: Impaired ability to mediate deacetylation of STAT3 | Y | |
3 | P30203 | T-cell differentiation antigen CD6 | 668 | 291 291 D->A: Strongly reduces interaction with ALCAM 293 293 E->A: Reduces interaction with ALCAM 295 295 Y->A: Abolishes interaction with ALCAM 298 298 E->A: Nearly abolishes interaction with ALCAM 314 314 R->A: Reduces interaction with ALCAM 327 327 Y->A: Nearly abolishes interaction with ALCAM 329 329 S->A: Reduces interaction with ALCAM 346 346 N->A: Strongly reduces interaction with ALCAM 349 349 L->A: Reduces interaction with ALCAM 352 352 Q->A: Reduces interaction with ALCAM 353 353 S->A: Reduces interaction with ALCAM 662 662 Y->F: Reduces tyrosine phosphorylation | Y | |
4 | Q86VB7 | Scavenger receptor cysteine-rich type 1 protein M130 | 1156 | 1072 1072 T->A: Impaired phosphorylation by PRKCA 1084 1084 S->A: Impaired phosphorylation by PRKCA 1096 1096 Y->A: Massive decrease of endocytotic activity | N | |
5 | Q9Y4K0 | Lysyl oxidase homolog 2 | 774 | 455 455 N->Q: Inhibits secretion 626 628 626 628 HRH->ARA: Abolishes oxidase activity and oxidation of trimethylated 'Lys-4' of histone H3 but does not affect secretion, interaction with SNAI1, binding to the CDH1 promoter, repression of CDH1 transcription or ability to induce EMT 626 626 H->A: Loss of enzyme activity 628 628 H->A: Loss of enzyme activity 630 630 H->A: Loss of enzyme activity 644 644 N->Q: Inhibits secretion 653 653 K->A: Loss of enzyme activity 689 689 Y->A: Loss of enzyme activity 689 689 Y->F: Does not affect ability to inhibit keratinocyte differentiation | Y | |