S.NO | Uniprot ID | Protein Name | Sequence Length | Thioredoxin Region | Mutation | Involvement of Repeats in Mutations |
1 | Q15084 | Protein disulfide-isomerase A6 | 440 | 55 55 C->S: 50% decrease in enzyme activity when associated with S-58 when associated with S-58 S-190 and S-193 58 58 C->A: Accelerates dephosphorylation of ERN1 when associated with A-193 58 58 C->S: 50% decrease in enzyme activity when associated with S-55 when associated with S-193 when associated with S-55 S-190 and S-193 190 190 C->S: 25% decrease in enzyme activity when associated with S-193 when associated with S-55 S-58 and S-193 193 193 C->A: Accelerates dephosphorylation of ERN1 when associated with A-58 193 193 C->S: 90% decrease in enzyme activity when associated with S-58 when associated with S-190 when associated with S-55 S-58 and S-190 | Y | |
2 | P30101 | Protein disulfide-isomerase A3 | 505 | 57 57 C->A: No loss of activity when associated with A-406 57 57 C->S: Activity changed to serine protease 60 60 C->S: Activity changed to serine protease when associated with S-409 406 406 C->A: No loss of activity when associated with A-57 406 406 C->S: Activity changed to serine protease 409 409 C->S: Activity changed to serine protease when associated with S-60 | Y | |
3 | Q13087 | Protein disulfide-isomerase A2 | 525 | 18 18 C->A: Impairs interchain disulfide bridge formation 284 284 N->Q: Increases formation of a highly stable disulfide-bonded PDIA2 dimer 364 364 C->A: No effect on interchain disulfide bridge formation | N | |
4 | Q8IXB1 | DnaJ homolog subfamily C member 10 | 793 | 63 63 H->Q: Prevents interaction with HSPA5, leading to prolonged interaction with substrate proteins 161 161 C->A: Abolishes disulfide reductase activity when associated with A-483 A-591 and A-703 483 483 C->A: Abolishes disulfide reductase activity when associated with A-161 A-591 and A-703 591 591 C->A: Abolishes disulfide reductase activity when associated with A-161 A-483 and A-703 703 703 C->A: Abolishes disulfide reductase activity when associated with A-161 A-483 and A-591 | Y | |