| S.NO | Uniprot ID | Protein Name | Sequence Length | Tudor Region | Mutation | Involvement of Repeats in Mutations |
| 1 | O75164 | Lysine-specific demethylase 4A | 1064 | 133 133 G->A: Abolishes histone demethylase activity when associated with A-138 138 138 G->A: Abolishes histone demethylase activity when associated with A-138 165 165 G->A: Abolishes histone demethylase activity when associated with A-165 170 170 G->A: Abolishes histone demethylase activity when associated with A-165 188 188 H->A: Abolishes histone demethylase activity without affecting ability to bind H4K20me2 288 289 288 289 ST->AI: Displays histone demethylase activity for both dimethylated and H3-K9Me3 288 289 288 289 ST->TV,NV,GG: Abolishes histone demethylase activity 939 939 D->R: Impairs binding to H4K20me2, promoting partial recruitment of TP53BP1 945 945 D->A: Impairs binding to H3K4me3 945 945 D->R: Abolishes binding to H3K4me3 967 967 W->H: Abolishes binding to H3K4me3 973 973 Y->A: Abolishes binding to H3K4me3 | Y | |
| 2 | O94953 | Lysine-specific demethylase 4B | 1096 | 189 191
189 191 HTE->ATA: Abolishes lysine-specific histone demethylase activity | N | |
| 3 | Q9H3R0 | Lysine-specific demethylase 4C | 1056 | 190 192
190 192 HTE->ATA: Abolishes lysine-specific histone demethylase activity | N | |
| 4 | Q15047 | Histone-lysine N-methyltransferase SETDB1 | 1291 | 729 731
729 731 CDC->LDP: Abolishes methyltransferase activity 976 976 T->A: Abrogates interaction with CHD7, NLK and PPARG 1224 1224 H->K: Abolishes methyltransferase activity 1226 1226 C->A: Abolishes methyltransferase activity 1279 1279 C->Y: Abolishes methyltransferase activity | N | |
| 5 | Q9BVI0 | PHD finger protein 20 | 1012 | 96 96 C->S: Abolishes homodimerization 97 97 W->A: Abolishes interaction with methylated p53 100 100 C->S: Abolishes homodimerization 103 103 Y->A: Abolishes interaction with methylated p53 | Y | |