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The 3 VWFD Repeats and their Mutations

S.NO	Uniprot ID	Protein Name	Sequence Length	VWFD Region	Mutation	Involvement of Repeats in Mutations
1	P04275	von Willebrand factor	2813	34 240 DOMAIN 34 240 VWFD 1 387 598 DOMAIN 387 598 VWFD 2 866 1074 DOMAIN 866 1074 VWFD 3 1949 2153 DOMAIN 1949 2153 VWFD 4	1149 1149 C->R: Reduced secretion and increased intracellular retention when associated with S-1169 1169 1169 C->S: Reduced secretion and increased intracellular retention when associated with R-1149	N
2	Q9HC84	Mucin-5B	5762	76 277 DOMAIN 76 277 VWFD 1 424 638 DOMAIN 424 638 VWFD 2 894 1099 DOMAIN 894 1099 VWFD 3 5074 5305 DOMAIN 5074 5305 VWFD 4	1790 1790 W->A: Poorly secreted	N
3	P98088	Mucin-5AC	5654	80 281 DOMAIN 80 281 VWFD 1 433 647 DOMAIN 433 647 VWFD 2 902 1109 DOMAIN 902 1109 VWFD 3 4920 5131 DOMAIN 4920 5131 VWFD 4	2122 2122 W->A: No binding to mannose-specific lectin 4926 4926 D->A,E: Abolishes cleavage	Y