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The 2 WH2 Repeats and their Mutations

S.NOUniprot IDProtein Name Sequence LengthWH2 RegionMutationInvolvement of Repeats in Mutations
1 Q08AE8 Protein spire homolog 1 756131 131 I->K: Strongly reduces interaction with FMN2
134 134 Y->K: Abolishes interaction with FMN2
138 138 D->N: Abolishes interaction with FMN2
146 146 E->A,K: Abolishes interaction with FMN2
N
2 Q8TF30 "WASP homolog-associated protein with actin, membranes and microtubules "809807 807 W->A: Decreases nucleation-promoting factor activity and Arp2/3 complex activation
N