S.NO | Uniprot ID | Protein Name | Sequence Length | ARM Repeats region | Mutations | Involvement of Repeats in Mutations |
1 | P14923 | Junction plakoglobin | 745 | 14 14 T->A: Abolishes glycosylation 19 19 T->A: Reduces glycosylation 21 21 T->A: Does not affect glycosylation 24 24 S->A: Does not affect glycosylation 28 28 S->A: Does not affect glycosylation 32 32 T->A: Does not affect glycosylation | N | |
2 | P35222 | Catenin beta-1 | 781 | 29 29 S->F: No effect 64 64 Y->F: Abolishes phosphorylation by PTK6 142 142 Y->E: No effect on interaction with BCL9 and BCL9L 156 156 L->A: Abolishes interaction with BCL9 but no effect on interaction with CDH3 when associated with A-159 159 159 L->A: No effect on interaction with BCL9 and CDH3 when associated with A-156 178 178 L->A: No effect on interaction with BCL9 and CDH3 253 253 F->A: Abolishes or strongly reduces AXIN2 binding 260 260 H->A: Abolishes or strongly reduces AXIN1 and AXIN2 binding when associated with A-386 and A-383 292 292 K->A: Abolishes or strongly reduces AXIN1 and AXIN2 binding 312 312 K->E: Abolishes TCF7L2 binding 345 345 K->A: Abolishes APC binding 383 383 W->A: Abolishes APC binding when associated with A-260 and A-386 386 386 R->A: Strongly reduces APC binding when associated with A-260 and A-383 426 426 N->A: Abolishes TCF7L2 and LEF1 binding 435 435 K->A: Strongly reduces or abolishes LEF1 binding 435 435 K->E: Abolishes TCF7L2 binding 469 469 R->A: Abolishes TCF7L2 binding, and strongly reduces or abolishes LEF1 binding 470 470 H->A: Abolishes TCF7L2 binding, and strongly reduces or abolishes LEF1 binding 508 508 K->A: Abolishes TCF7L2 and LEF1 binding 654 654 Y->E: Enhances TBP binding and transactivation of target genes 654 654 Y->F: Abolishes increase of TBP binding after phosphorylation by CSK 660 660 F->A: Abolishes CTNNBIP1 binding when associated with A-661 661 661 R->A: Abolishes CTNNBIP1 binding when associated with A-660 | Y | |
3 | O60763 | General vesicular transport factor p115 | 962 | 942 942 S->A: Loss of phosphorylation 942 942 S->D: Decreased association with Golgi membranes | N | |
4 | O60716 | Catenin delta-1 | 968 | 363 363 W->A: Severely disrupts cadherin interaction 401 401 K->M: Complete loss of cadherin interaction 444 444 K->M: Severely disrupts cadherin interaction 477 477 W->A: Severely disrupts cadherin interaction 478 478 N->A: Complete loss of cadherin interaction | Y | |
5 | P25054 | Adenomatous polyposis coli protein | 2843 | 516 516 K->E: Impairs interaction with KHDRBS1 549 549 R->E: Impairs interaction with KHDRBS1 2841 2841 T->L: Loss of interaction with SCRIB 2843 2843 V->Q: Loss of interaction with SCRIB | Y | |