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Details of 5 ARM Repeats and their Mutations

S.NOUniprot ID Protein Name Sequence LengthARM Repeats regionMutationsInvolvement of Repeats in Mutations
1 P14923 Junction plakoglobin 74514 14 T->A: Abolishes glycosylation
19 19 T->A: Reduces glycosylation
21 21 T->A: Does not affect glycosylation
24 24 S->A: Does not affect glycosylation
28 28 S->A: Does not affect glycosylation
32 32 T->A: Does not affect glycosylation
N
2 P35222 Catenin beta-1 78129 29 S->F: No effect
64 64 Y->F: Abolishes phosphorylation by PTK6
142 142 Y->E: No effect on interaction with BCL9 and BCL9L
156 156 L->A: Abolishes interaction with BCL9 but no effect on interaction with CDH3
when associated with A-159
159 159 L->A: No effect on interaction with BCL9 and CDH3
when associated with A-156
178 178 L->A: No effect on interaction with BCL9 and CDH3
253 253 F->A: Abolishes or strongly reduces AXIN2 binding
260 260 H->A: Abolishes or strongly reduces AXIN1 and AXIN2 binding
when associated with A-386 and A-383
292 292 K->A: Abolishes or strongly reduces AXIN1 and AXIN2 binding
312 312 K->E: Abolishes TCF7L2 binding
345 345 K->A: Abolishes APC binding
383 383 W->A: Abolishes APC binding
when associated with A-260 and A-386
386 386 R->A: Strongly reduces APC binding
when associated with A-260 and A-383
426 426 N->A: Abolishes TCF7L2 and LEF1 binding
435 435 K->A: Strongly reduces or abolishes LEF1 binding
435 435 K->E: Abolishes TCF7L2 binding
469 469 R->A: Abolishes TCF7L2 binding, and strongly reduces or abolishes LEF1 binding
470 470 H->A: Abolishes TCF7L2 binding, and strongly reduces or abolishes LEF1 binding
508 508 K->A: Abolishes TCF7L2 and LEF1 binding
654 654 Y->E: Enhances TBP binding and transactivation of target genes
654 654 Y->F: Abolishes increase of TBP binding after phosphorylation by CSK
660 660 F->A: Abolishes CTNNBIP1 binding
when associated with A-661
661 661 R->A: Abolishes CTNNBIP1 binding
when associated with A-660
Y
3 O60763 General vesicular transport factor p115 962942 942 S->A: Loss of phosphorylation
942 942 S->D: Decreased association with Golgi membranes
N
4 O60716 Catenin delta-1 968363 363 W->A: Severely disrupts cadherin interaction
401 401 K->M: Complete loss of cadherin interaction
444 444 K->M: Severely disrupts cadherin interaction
477 477 W->A: Severely disrupts cadherin interaction
478 478 N->A: Complete loss of cadherin interaction
Y
5 P25054 Adenomatous polyposis coli protein 2843516 516 K->E: Impairs interaction with KHDRBS1
549 549 R->E: Impairs interaction with KHDRBS1
2841 2841 T->L: Loss of interaction with SCRIB
2843 2843 V->Q: Loss of interaction with SCRIB
Y