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O75807 Proteins with OtherRepeats Repeats
Uniprot ID: O75807
Protein name : Protein phosphatase 1 regulatory subunit 15A
Gene : PPP1R15A GADD34
Protein Families : PPP1R15 family
Squence Length : 674
Sequence
>O75807 675 MAPGQAPHQATPWRDAHPFFLLSPVMGLLSRAWSRLRGLGPLEPWLVEAVKGAALVEAGLEGEARTPLAIPHTPWGRRPEEEAEDSGGPGEDRETLGLKTSSSLPEAWGLLDDDDGMYGEREATSVPRGQGSQFADGQRAPLSPSLLIRTLQGSDKNPGEEKAEEEGVAEEEGVNKFSYPPSHRECCPAVEEEDDEEAVKKEAHRTSTSALSPGSKPSTWVSCPGEEENQATEDKRTERSKGARKTSVSPRSSGSDPRSWEYRSGEASEEKEEKAHKETGKGEAAPGPQSSAPAQRPQLKSWWCQPSDEEEGEVKALGAAEKDGEAECPPCIPPPSAFLKAWVYWPGEDTEEEEDEEEDEDSDSGSDEEEGEAEASSSTPATGVFLKSWVYQPGEDTEEEEDEDSDTGSAEDEREAETSASTPPASAFLKAWVYRPGEDTEEEEDEDVDSEDKEDDSEAALGEAESDPHPSHPDQRAHFRGWGYRPGKETEEEEAAEDWGEAEPCPFRVAIYVPGEKPPPPWAPPRLPLRLQRRLKRPETPTHDPDPETPLKARKVRFSEKVTVHFLAVWAGPAQAARQGPWEQLARDRSRFARRITQAQEELSPCLTPAARARAWARLRNPPLAPIPALTQTLPSSSVPSSPVQTTPLSQAVATPSRSSAAAAAALDLSGRRG
Repeat regions
REPEAT 337 369 1 REPEAT 384 417 2 REPEAT 427 460 3 REPEAT 477 510 4
Sequence region of repeats
337- 369 LKAWVYWPGEDTEEEEDEEEDEDSDSGSDEEEG 384- 417 LKSWVYQPGEDTEEEEDEDSDTGSAEDEREAETS 427- 460 LKAWVYRPGEDTEEEEDEDVDSEDKEDDSEAALG 477- 510 FRGWGYRPGKETEEEEAAEDWGEAEPCPFRVAIY
Function
"Recruits the serine/threonine-protein phosphatase PP1 to dephosphorylate the translation initiation factor eIF-2A/EIF2S1, thereby reversing the shut-off of protein synthesis initiated by stress-inducible kinases and facilitating recovery of cells from stress. Down-regulates the TGF-beta signaling pathway by promoting dephosphorylation of TGFB1 by PP1. May promote apoptosis by inducing TP53 phosphorylation on 'Ser-15'"
Mutation
"25 25 V->R: Localizes to cytoplasm, degraded more slowly 29 29 L->R: Localizes to cytoplasm 262 262 Y->F: Significantly reduced turnover 555 558 KVRF->AAAA: Reduces interaction with SMARCB1 556 558 VRF->ARA: Impairs PP1 activation 612 612 R->K: Reduces PP1-binding when associated with K-614 614 614 R->K: Reduces PP1-binding when associated with K-612 618 618 R->D: Reduces PP1-binding"