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P05556 Proteins with OtherRepeats Repeats
Uniprot ID: P05556
Protein name : Integrin beta-1
Gene : ITGB1 FNRB MDF2 MSK12
Protein Families : Integrin beta chain family
Squence Length : 798
Sequence
>P05556 799 MNLQPIFWIGLISSVCCVFAQTDENRCLKANAKSCGECIQAGPNCGWCTNSTFLQEGMPTSARCDDLEALKKKGCPPDDIENPRGSKDIKKNKNVTNRSKGTAEKLKPEDITQIQPQQLVLRLRSGEPQTFTLKFKRAEDYPIDLYYLMDLSYSMKDDLENVKSLGTDLMNEMRRITSDFRIGFGSFVEKTVMPYISTTPAKLRNPCTSEQNCTSPFSYKNVLSLTNKGEVFNELVGKQRISGNLDSPEGGFDAIMQVAVCGSLIGWRNVTRLLVFSTDAGFHFAGDGKLGGIVLPNDGQCHLENNMYTMSHYYDYPSIAHLVQKLSENNIQTIFAVTEEFQPVYKELKNLIPKSAVGTLSANSSNVIQLIIDAYNSLSSEVILENGKLSEGVTISYKSYCKNGVNGTGENGRKCSNISIGDEVQFEISITSNKCPKKDSDSFKIRPLGFTEEVEVILQYICECECQSEGIPESPKCHEGNGTFECGACRCNEGRVGRHCECSTDEVNSEDMDAYCRKENSSEICSNNGECVCGQCVCRKRDNTNEIYSGKFCECDNFNCDRSNGLICGGNGVCKCRVCECNPNYTGSACDCSLDTSTCEASNGQICNGRGICECGVCKCTDPKFQGQTCEMCQTCLGVCAEHKECVQCRAFNKGEKKDTCTQECSYFNITKVESRDKLPQPVQPDPVSHCKEKDVDDCWFYFTYSVNGNNEVMVHVVENPECPTGPDIIPIVAGVVAGIVLIGLALLLIWKLLMIIHDRREFAKFEKEKMNAKWDTGENPIYKSAVTTVVNPKYEGK
Repeat regions
REPEAT 466 515 I REPEAT 516 559 II REPEAT 560 598 III REPEAT 599 635 IV
Sequence region of repeats
466- 515 SEGIPESPKCHEGNGTFECGACRCNEGRVGRHCECSTDEVNSEDMDAYCR 516- 559 KENSSEICSNNGECVCGQCVCRKRDNTNEIYSGKFCECDNFNCD 560- 598 RSNGLICGGNGVCKCRVCECNPNYTGSACDCSLDTSTCE 599- 635 ASNGQICNGRGICECGVCKCTDPKFQGQTCEMCQTCL
Domains
DOMAIN 140 378 VWFA
Function
"Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta-1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha-1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha-3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha-10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin alpha-1/beta-1, alpha-2/beta-1, alpha-6/beta-1 and alpha-7/beta-1 are receptors for lamimin. Integrin alpha-4/beta-1 is a receptor for VCAM1. It recognizes the sequence Q-I-D-S in VCAM1. Integrin alpha-9/beta-1 is a receptor for VCAM1, cytotactin and osteopontin. It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin. Integrin alpha-3/beta-1 is a receptor for epiligrin, thrombospondin and CSPG4. Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration. Integrin alpha-V/beta-1 is a receptor for vitronectin. Beta-1 integrins recognize the sequence R-G-D in a wide array of ligands. Isoform 2 interferes with isoform 1 resulting in a dominant negative effect on cell adhesion and migration (in vitro). When associated with alpha-7/beta-1 integrin, regulates cell adhesion and laminin matrix deposition. Involved in promoting endothelial cell motility and angiogenesis. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process and the formation of mineralized bone nodules. May be involved in up-regulation of the activity of kinases such as PKC via binding to KRT1. Together with KRT1 and RACK1, serves as a platform for SRC activation or inactivation. Plays a mechanistic adhesive role during telophase, required for the successful completion of cytokinesis. Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion. ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415, PubMed:24789099). ITGA4:ITGB1 and ITGA5:ITGB1 bind to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877). ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881). ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (PubMed:29030430).; Isoform 5: Isoform 5 displaces isoform 1 in striated muscles.; (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human echoviruses 1 and 8.; (Microbial infection) Acts as a receptor for Cytomegalovirus/HHV-5.; (Microbial infection) Acts as a receptor for Epstein-Barr virus/HHV-4.; (Microbial infection) Integrin ITGA5:ITGB1 acts as a receptor for Human parvovirus B19.; (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human rotavirus.; (Microbial infection) Acts as a receptor for Mammalian reovirus.; (Microbial infection) In case of HIV-1 infection, integrin ITGA5:ITGB1 binding to extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions"
Mutation
"760 761 RR->AA: No effect on interaction with ACAP1 762 767 EFAKFE->AAAAAA: Strongly reduces interaction with ACAP1 and ability to recycle does not affect heterodimerization with ITGA5 762 763 EF->AA: Slightly reduces interaction with ACAP1 765 765 K->A: Reduces interaction with ACAP1 766 767 FE->AA: Slightly reduces interaction with ACAP1 768 769 KE->AA: No effect on interaction with ACAP1 778 778 G->Q: Loss of beta-1A interaction with FLNA and FLNB 786 791 AVTTVV->PINNFK: Does not interact with ITGB1BP1 786 786 A->P: Loss of beta-1A interaction with FLNA and FLNB 787 787 V->T: Reduces interaction with ITGB1BP1, but not with FERMT2 or TLN1 788 788 T->D: Strongly reduces ITGB1BP1 binding when associated with D-790 790 790 V->D: Strongly reduces ITGB1BP1 binding when associated with D-788 792 792 N->A: Strongly reduces ITGB1BP1 binding when associated with A-795 795 795 Y->A: Strongly reduces ITGB1BP1 binding when associated with A-792"