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P12259 Proteins with OtherRepeats Repeats
Uniprot ID: P12259
Protein name : Coagulation factor V
Gene : F5
Protein Families : Multicopper oxidase family
Squence Length : 2224
Sequence
>P12259 2225 MFPGCPRLWVLVVLGTSWVGWGSQGTEAAQLRQFYVAAQGISWSYRPEPTNSSLNLSVTSFKKIVYREYEPYFKKEKPQSTISGLLGPTLYAEVGDIIKVHFKNKADKPLSIHPQGIRYSKLSEGASYLDHTFPAEKMDDAVAPGREYTYEWSISEDSGPTHDDPPCLTHIYYSHENLIEDFNSGLIGPLLICKKGTLTEGGTQKTFDKQIVLLFAVFDESKSWSQSSSLMYTVNGYVNGTMPDITVCAHDHISWHLLGMSSGPELFSIHFNGQVLEQNHHKVSAITLVSATSTTANMTVGPEGKWIISSLTPKHLQAGMQAYIDIKNCPKKTRNLKKITREQRRHMKRWEYFIAAEEVIWDYAPVIPANMDKKYRSQHLDNFSNQIGKHYKKVMYTQYEDESFTKHTVNPNMKEDGILGPIIRAQVRDTLKIVFKNMASRPYSIYPHGVTFSPYEDEVNSSFTSGRNNTMIRAVQPGETYTYKWNILEFDEPTENDAQCLTRPYYSDVDIMRDIASGLIGLLLICKSRSLDRRGIQRAADIEQQAVFAVFDENKSWYLEDNINKFCENPDEVKRDDPKFYESNIMSTINGYVPESITTLGFCFDDTVQWHFCSVGTQNEILTIHFTGHSFIYGKRHEDTLTLFPMRGESVTVTMDNVGTWMLTSMNSSPRSKKLRLKFRDVKCIPDDDEDSYEIFEPPESTVMATRKMHDRLEPEDEESDADYDYQNRLAAALGIRSFRNSSLNQEEEEFNLTALALENGTEFVSSNTDIIVGSNYSSPSNISKFTVNNLAEPQKAPSHQQATTAGSPLRHLIGKNSVLNSSTAEHSSPYSEDPIEDPLQPDVTGIRLLSLGAGEFKSQEHAKHKGPKVERDQAAKHRFSWMKLLAHKVGRHLSQDTGSPSGMRPWEDLPSQDTGSPSRMRPWKDPPSDLLLLKQSNSSKILVGRWHLASEKGSYEIIQDTDEDTAVNNWLISPQNASRAWGESTPLANKPGKQSGHPKFPRVRHKSLQVRQDGGKSRLKKSQFLIKTRKKKKEKHTHHAPLSPRTFHPLRSEAYNTFSERRLKHSLVLHKSNETSLPTDLNQTLPSMDFGWIASLPDHNQNSSNDTGQASCPPGLYQTVPPEEHYQTFPIQDPDQMHSTSDPSHRSSSPELSEMLEYDRSHKSFPTDISQMSPSSEHEVWQTVISPDLSQVTLSPELSQTNLSPDLSHTTLSPELIQRNLSPALGQMPISPDLSHTTLSPDLSHTTLSLDLSQTNLSPELSQTNLSPALGQMPLSPDLSHTTLSLDFSQTNLSPELSHMTLSPELSQTNLSPALGQMPISPDLSHTTLSLDFSQTNLSPELSQTNLSPALGQMPLSPDPSHTTLSLDLSQTNLSPELSQTNLSPDLSEMPLFADLSQIPLTPDLDQMTLSPDLGETDLSPNFGQMSLSPDLSQVTLSPDISDTTLLPDLSQISPPPDLDQIFYPSESSQSLLLQEFNESFPYPDLGQMPSPSSPTLNDTFLSKEFNPLVIVGLSKDGTDYIEIIPKEEVQSSEDDYAEIDYVPYDDPYKTDVRTNINSSRDPDNIAAWYLRSNNGNRRNYYIAAEEISWDYSEFVQRETDIEDSDDIPEDTTYKKVVFRKYLDSTFTKRDPRGEYEEHLGILGPIIRAEVDDVIQVRFKNLASRPYSLHAHGLSYEKSSEGKTYEDDSPEWFKEDNAVQPNSSYTYVWHATERSGPESPGSACRAWAYYSAVNPEKDIHSGLIGPLLICQKGILHKDSNMPMDMREFVLLFMTFDEKKSWYYEKKSRSSWRLTSSEMKKSHEFHAINGMIYSLPGLKMYEQEWVRLHLLNIGGSQDIHVVHFHGQTLLENGNKQHQLGVWPLLPGSFKTLEMKASKPGWWLLNTEVGENQRAGMQTPFLIMDRDCRMPMGLSTGIISDSQIKASEFLGYWEPRLARLNNGGSYNAWSVEKLAAEFASKPWIQVDMQKEVIITGIQTQGAKHYLKSCYTTEFYVAYSSNQINWQIFKGNSTRNVMYFNGNSDASTIKENQFDPPIVARYIRISPTRAYNRPTLRLELQGCEVNGCSTPLGMENGKIENKQITASSFKKSWWGDYWEPFRARLNAQGRVNAWQAKANNNKQWLEIDLLKIKKITAIITQGCKSLSSEMYVKSYTIHYSEQGVEWKPYRLKSSMVDKIFEGNTNTKGHVKNFFNPPIISRFIRVIPKTWNQSIALRLELFGCDIY
Repeat regions
REPEAT 895 911 1-1 REPEAT 912 928 1-2 REPEAT 1185 1193 2-1 REPEAT 1194 1202 2-2 REPEAT 1203 1211 2-3 REPEAT 1212 1220 2-4 REPEAT 1221 1229 2-5 REPEAT 1230 1238 2-6 REPEAT 1239 1247 2-7 REPEAT 1248 1256 2-8 REPEAT 1257 1265 2-9 REPEAT 1266 1274 2-10 REPEAT 1275 1283 2-11 REPEAT 1284 1292 2-12 REPEAT 1293 1301 2-13 REPEAT 1302 1310 2-14 REPEAT 1311 1319 2-15 REPEAT 1320 1328 2-16 REPEAT 1329 1337 2-17 REPEAT 1338 1346 2-18 REPEAT 1347 1355 2-19 REPEAT 1356 1364 2-20 REPEAT 1365 1373 2-21 REPEAT 1374 1382 2-22 REPEAT 1383 1391 2-23 REPEAT 1392 1400 2-24 REPEAT 1401 1409 2-25 REPEAT 1410 1418 2-26 REPEAT 1419 1427 2-27 REPEAT 1428 1436 2-28 REPEAT 1437 1445 2-29 REPEAT 1446 1454 2-30 REPEAT 1455 1463 2-31 REPEAT 1464 1472 2-32 REPEAT 1473 1481 2-33 REPEAT 1482 1490 2-34 REPEAT 1493 1501 2-35
Sequence region of repeats
895- 911 DTGSPSGMRPWEDLPSQ 912- 928 DTGSPSRMRPWKDPPSD 1185- 1193 SPDLSQVTL 1194- 1202 SPELSQTNL 1203- 1211 SPDLSHTTL 1212- 1220 SPELIQRNL 1221- 1229 SPALGQMPI 1230- 1238 SPDLSHTTL 1239- 1247 SPDLSHTTL 1248- 1256 SLDLSQTNL 1257- 1265 SPELSQTNL 1266- 1274 SPALGQMPL 1275- 1283 SPDLSHTTL 1284- 1292 SLDFSQTNL 1293- 1301 SPELSHMTL 1302- 1310 SPELSQTNL 1311- 1319 SPALGQMPI 1320- 1328 SPDLSHTTL 1329- 1337 SLDFSQTNL 1338- 1346 SPELSQTNL 1347- 1355 SPALGQMPL 1356- 1364 SPDPSHTTL 1365- 1373 SLDLSQTNL 1374- 1382 SPELSQTNL 1383- 1391 SPDLSEMPL 1392- 1400 FADLSQIPL 1401- 1409 TPDLDQMTL 1410- 1418 SPDLGETDL 1419- 1427 SPNFGQMSL 1428- 1436 SPDLSQVTL 1437- 1445 SPDISDTTL 1446- 1454 LPDLSQISP 1455- 1463 PPDLDQIFY 1464- 1472 PSESSQSLL 1473- 1481 LQEFNESFP 1482- 1490 YPDLGQMPS 1493- 1501 SPTLNDTFL
Domains
DOMAIN 30 329 F5/8 type A 1. DOMAIN 30 193 Plastocyanin-like 1. DOMAIN 203 329 Plastocyanin-like 2. DOMAIN 348 684 F5/8 type A 2. DOMAIN 348 526 Plastocyanin-like 3. DOMAIN 536 684 Plastocyanin-like 4. DOMAIN 1578 1907 F5/8 type A 3. DOMAIN 1578 1751 Plastocyanin-like 5. DOMAIN 1761 1907 Plastocyanin-like 6. DOMAIN 1907 2061 F5/8 type C 1. DOMAIN 2066 2221 F5/8 type C 2
Function
Central regulator of hemostasis. It serves as a critical cofactor for the prothrombinase activity of factor Xa that results in the activation of prothrombin to thrombin
Mutation
Disease
"DISEASE: Factor V deficiency (FA5D) [MIM:227400]: A blood coagulation disorder leading to a hemorrhagic diathesis known as parahemophilia Note=The disease is caused by mutations affecting the gene represented in this entry ; DISEASE: Thrombophilia due to activated protein C resistance (THPH2) [MIM:188055]: A hemostatic disorder due to defective degradation of factor V by activated protein C It is characterized by a poor anticoagulant response to activated protein C resulting in tendency to thrombosis Note=The disease is caused by mutations affecting the gene represented in this entry ; DISEASE: Budd-Chiari syndrome (BDCHS) [MIM:600880]: A syndrome caused by obstruction of hepatic venous outflow involving either the hepatic veins or the terminal segment of the inferior vena cava Obstructions are generally caused by thrombosis and lead to hepatic congestion and ischemic necrosis Clinical manifestations observed in the majority of patients include hepatomegaly, right upper quadrant pain and abdominal ascites Budd-Chiari syndrome is associated with a combination of disease states including primary myeloproliferative syndromes and thrombophilia due to factor V Leiden, protein C deficiency and antithrombin III deficiency Budd-Chiari syndrome is a rare but typical complication in patients with polycythemia vera Note=Disease susceptibility is associated with variations affecting the gene represented in this entry ; DISEASE: Ischemic stroke (ISCHSTR) [MIM:601367]: A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors Note=Disease susceptibility is associated with variations affecting the gene represented in this entry ; DISEASE: Pregnancy loss, recurrent, 1 (RPRGL1) [MIM:614389]: A common complication of pregnancy, resulting in spontaneous abortion before the fetus has reached viability The term includes all miscarriages from the time of conception until 24 weeks of gestation Recurrent pregnancy loss is defined as 3 or more consecutive spontaneous abortions Note=Disease susceptibility is associated with variations affecting the gene represented in this entry"