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P17931 Proteins with OtherRepeats Repeats
Uniprot ID: P17931
Protein name : Galectin-3
Gene : LGALS3 MAC2
Protein Families :
Squence Length : 250
Sequence
>P17931 251 MADNFSLHDALSGSGNPNPQGWPGAWGNQPAGAGGYPGASYPGAYPGQAPPGAYPGQAPPGAYPGAPGAYPGAPAPGVYPGPPSGPGAYPSSGQPSATGAYPATGPYGAPAGPLIVPYNLPLPGGVVPRMLITILGTVKPNANRIALDFQRGNDVAFHFNPRFNENNRRVIVCNTKLDNNWGREERQSVFPFESGKPFKIQVLVEPDHFKVAVNDAHLLQYNHRVKKLNEISKLGISGDIDLTSASYTMI
Repeat regions
REPEAT 36 44 1 REPEAT 45 53 2 REPEAT 54 62 3 REPEAT 63 69 4 approximate REPEAT 70 78 5 REPEAT 79 88 6 approximate REPEAT 89 100 7 approximate REPEAT 101 109 8 approximate
Sequence region of repeats
36- 44 GASYPGAYP 45- 53 GQAPPGAYP 54- 62 GQAPPGAYP 63- 69 GAPGAYP - A 70- 78 GAPAPGVYP 79- 88 GPPSGPGAYP - A 89- 100 SSGQPSATGAYP - A 101- 109 ATGPYGAPA - A
Domains
DOMAIN 118 248 Galectin
Function
"Galactose-specific lectin which binds IgE. May mediate with the alpha-3, beta-1 integrin the stimulation by CSPG4 of endothelial cells migration. Together with DMBT1, required for terminal differentiation of columnar epithelial cells during early embryogenesis (By similarity). In the nucleus: acts as a pre-mRNA splicing factor. Involved in acute inflammatory responses including neutrophil activation and adhesion, chemoattraction of monocytes macrophages, opsonization of apoptotic neutrophils, and activation of mast cells"
Motifs
MOTIF 226 241 Nuclear export signal
Mutation