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P18615 Proteins with OtherRepeats Repeats
Uniprot ID: P18615
Protein name : Negative elongation factor E
Gene : NELFE RD RDBP
Protein Families : RRM NELF-E family
Squence Length : 380
Sequence
>P18615 381 MLVIPPGLSEEEEALQKKFNKLKKKKKALLALKKQSSSSTTSQGGVKRSLSEQPVMDTATATEQAKQLVKSGAISAIKAETKNSGFKRSRTLEGKLKDPEKGPVPTFQPFQRSISADDDLQESSRRPQRKSLYESFVSSSDRLRELGPDGEEAEGPGAGDGPPRSFDWGYEERSGAHSSASPPRSRSRDRSHERNRDRDRDRERDRDRDRDRDRERDRDRDRDRDRDRERDRDRERDRDRDREGPFRRSDSFPERRAPRKGNTLYVYGEDMTPTLLRGAFSPFGNIIDLSMDPPRNCAFVTYEKMESADQAVAELNGTQVESVQLKVNIARKQPMLDAATGKSVWGSLAVQNSPKGCHRDKRTQIVYSDDVYKENLVDGF
Repeat regions
REPEAT 184 185 1 REPEAT 186 187 2 REPEAT 188 189 3 REPEAT 190 191 4 REPEAT 192 193 5 approximate REPEAT 194 195 6 REPEAT 196 197 7 REPEAT 198 199 8 REPEAT 200 201 9 REPEAT 202 203 10 REPEAT 204 205 11 REPEAT 206 207 12 REPEAT 208 209 13 REPEAT 210 211 14 REPEAT 212 213 15 REPEAT 214 215 16 REPEAT 216 217 17 REPEAT 218 219 18 REPEAT 220 221 19 REPEAT 222 223 20 REPEAT 224 225 21 REPEAT 226 227 22 REPEAT 228 229 23 REPEAT 230 231 24 REPEAT 232 233 25 REPEAT 234 235 26 REPEAT 236 237 27 REPEAT 238 239 28 REPEAT 240 241 29 REPEAT 242 243 30
Sequence region of repeats
184- 185 RS 186- 187 RD 188- 189 RS 190- 191 HE 192- 193 RN - L 194- 195 RD 196- 197 RD 198- 199 RD 200- 201 RE 202- 203 RD 204- 205 RD 206- 207 RD 208- 209 RD 210- 211 RD 212- 213 RE 214- 215 RD 216- 217 RD 218- 219 RD 220- 221 RD 222- 223 RD 224- 225 RD 226- 227 RE 228- 229 RD 230- 231 RD 232- 233 RE 234- 235 RD 236- 237 RD 238- 239 RD 240- 241 RE 242- 243 GP
Domains
DOMAIN 262 332 RRM
Function
"Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II. Provides the strongest RNA binding activity of the NELF complex and may initially recruit the NELF complex to RNA. Binds to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1"
Mutation
295 299 RNCAF->EQMAT: Abolishes interaction with RNA but not the interaction with other proteins of the NELF complex