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P21917 Proteins with OtherRepeats Repeats
Uniprot ID: P21917
Protein name : D
Gene : DRD4
Protein Families : G-protein coupled receptor 1 family
Squence Length : 467
Sequence
>P21917 468 MGNRSTADADGLLAGRGPAAGASAGASAGLAGQGAAALVGGVLLIGAVLAGNSLVCVSVATERALQTPTNSFIVSLAAADLLLALLVLPLFVYSEVQGGAWLLSPRLCDALMAMDVMLCTASIFNLCAISVDRFVAVAVPLRYNRQGGSRRQLLLIGATWLLSAAVAAPVLCGLNDVRGRDPAVCRLEDRDYVVYSSVCSFFLPCPLMLLLYWATFRGLQRWEVARRAKLHGRAPRRPSGPGPPSPTPPAPRLPQDPCGPDCAPPAPGLPRGPCGPDCAPAAPGLPPDPCGPDCAPPAPGLPQDPCGPDCAPPAPGLPRGPCGPDCAPPAPGLPQDPCGPDCAPPAPGLPPDPCGSNCAPPDAVRAAALPPQTPPQTRRRRRAKITGRERKAMRVLPVVVGAFLLCWTPFFVVHITQALCPACSVPPRLVSAVTWLGYVNSALNPVIYTVFNAEFRNVFRKALRACC
Repeat regions
REPEAT 249 264 1 approximate REPEAT 265 280 2 REPEAT 281 296 3 REPEAT 297 312 4 REPEAT 313 328 5 REPEAT 329 344 6 REPEAT 345 360 7 approximate
Sequence region of repeats
249- 264 PRLPQDPCGPDCAPPA - G 265- 280 PGLPRGPCGPDCAPAA 281- 296 PGLPPDPCGPDCAPPA 297- 312 PGLPQDPCGPDCAPPA 313- 328 PGLPRGPCGPDCAPPA 329- 344 PGLPQDPCGPDCAPPA 345- 360 PGLPPDPCGSNCAPPD - G
Function
"Dopamine receptor responsible for neuronal signaling in the mesolimbic system of the brain, an area of the brain that regulates emotion and complex behavior. Activated by dopamine, but also by epinephrine and norepinephrine, and by numerous synthetic agonists and drugs (PubMed:9003072, PubMed:16423344, PubMed:27659709, PubMed:29051383). Agonist binding triggers signaling via G proteins that inhibit adenylyl cyclase (PubMed:7512953, PubMed:7643093, PubMed:16423344, PubMed:27659709, PubMed:29051383). Modulates the circadian rhythm of contrast sensitivity by regulating the rhythmic expression of NPAS2 in the retinal ganglion cells (By similarity)"
Binding Site
BINDING 115 115 Agonist
Mutation
430 430 V->Y: Increased basal level of G protein-mediated signaling 466 466 C->G: No effect on palmitoylation 467 467 C->G: Loss of palmitoylation