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P50552 Proteins with OtherRepeats Repeats
Uniprot ID: P50552
Protein name : Vasodilator-stimulated phosphoprotein
Gene : VASP
Protein Families : Ena/VASP family
Squence Length : 380
Sequence
>P50552 381 MSETVICSSRATVMLYDDGNKRWLPAGTGPQAFSRVQIYHNPTANSFRVVGRKMQPDQQVVINCAIVRGVKYNQATPNFHQWRDARQVWGLNFGSKEDAAQFAAGMASALEALEGGGPPPPPALPTWSVPNGPSPEEVEQQKRQQPGPSEHIERRVSNAGGPPAPPAGGPPPPPGPPPPPGPPPPPGLPPSGVPAAAHGAGGGPPPAPPLPAAQGPGGGGAGAPGLAAAIAGAKLRKVSKQEEASGGPTAPKAESGRSGGGGLMEEMNAMLARRRKATQVGEKTPKDESANQEEPEARVPAQSESVRRPWEKNSTTLPRMKSSSSVTTSETQPCTPSSSDYSDLQRVKQELLEEVKKELQKVKEEIIEAFVQELRKRGSP
Repeat regions
REPEAT 344 358 1 REPEAT 359 373 2
Sequence region of repeats
344- 358 RVKQELLEEVKKELQ 359- 373 KVKEEIIEAFVQELR
Domains
DOMAIN 2 113 WH1
Function
"Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. VASP promotes actin filament elongation. It protects the barbed end of growing actin filaments against capping and increases the rate of actin polymerization in the presence of capping protein. VASP stimulates actin filament elongation by promoting the transfer of profilin-bound actin monomers onto the barbed end of growing actin filaments. Plays a role in actin-based mobility of Listeria monocytogenes in host cells. Regulates actin dynamics in platelets and plays an important role in regulating platelet aggregation"
Motifs
MOTIF 234 237 KLKR
Mutation
"157 157 S->A: Promotes F-actin assembly when associated with A-239 and A-278 when associated with A-239 and E-278 239 239 S->A: Promotes F-actin assembly when associated with A-157 and A-278 when associated with A-157 and E-278 278 278 T->A: Promotes F-actin assembly when associated with A-157 and A-239 278 278 T->E: Interferes with F-actin assembly when associated with A-157 and A-239 370 370 F->A: Lower stability of tetramerization domain 370 370 F->I,K: No change in stability of tetramerization domain"