Uniprot ID: Q14152	Protein name : Eukaryotic translation initiation factor 3 subunit A	Gene : EIF3A EIF3S10 KIAA0139
Protein Families : EIF-3 subunit A family	Squence Length : 1382

Sequence	>Q14152 1383 MPAYFQRPENALKRANEFLEVGKKQPALDVLYDVMKSKKHRTWQKIHEPIMLKYLELCVDLRKSHLAKEGLYQYKNICQQVNIKSLEDVVRAYLKMAEEKTEAAKEESQQMVLDIEDLDNIQTPESVLLSAVSGEDTQDRTDRLLLTPWVKFLWESYRQCLDLLRNNSRVERLYHDIAQQAFKFCLQYTRKAEFRKLCDNLRMHLSQIQRHHNQSTAINLNNPESQSMHLETRLVQLDSAISMELWQEAFKAVEDIHGLFSLSKKPPKPQLMANYYNKVSTVFWKSGNALFHASTLHRLYHLSREMRKNLTQDEMQRMSTRVLLATLSIPITPERTDIARLLDMDGIIVEKQRRLATLLGLQAPPTRIGLINDMVRFNVLQYVVPEVKDLYNWLEVEFNPLKLCERVTKVLNWVREQPEKEPELQQYVPQLQNNTILRLLQQVSQIYQSIEFSRLTSLVPFVDAFQLERAIVDAARHCDLQVRIDHTSRTLSFGSDLNYATREDAPIGPHLQSMPSEQIRNQLTAMSSVLAKALEVIKPAHILQEKEEQHQLAVTAYLKNSRKEHQRILARRQTIEERKERLESLNIQREKEELEQREAELQKVRKAEEERLRQEAKEREKERILQEHEQIKKKTVRERLEQIKKTELGAKAFKDIDIEDLEELDPDFIMAKQVEQLEKEKKELQERLKNQEKKIDYFERAKRLEEIPLIKSAYEEQRIKDMDLWEQQEEERITTMQLEREKALEHKNRMSRMLEDRDLFVMRLKAARQSVYEEKLKQFEERLAEERHNRLEERKRQRKEERRITYYREKEEEEQRRAEEQMLKEREERERAERAKREEELREYQERVKKLEEVERKKRQRELEIEERERRREEERRLGDSSLSRKDSRWGDRDSEGTWRKGPEADSEWRRGPPEKEWRRGEGRDEDRSHRRDEERPRRLGDDEDREPSLRPDDDRVPRRGMDDDRGPRRGPEEDRFSRRGADDDRPSWRNTDDDRPPRRIADEDRGNWRHADDDRPPRRGLDEDRGSWRTADEDRGPRRGMDDDRGPRRGGADDERSSWRNADDDRGPRRGLDDDRGPRRGMDDDRGPRRGMDDDRGPRRGMDDDRGPRRGLDDDRGPWRNADDDRIPRRGAEDDRGPWRNMDDDRLSRRADDDRFPRRGDDSRPGPWRPLVKPGGWREKEKAREESWGPPRESRPSEEREWDREKERDRDNQDREENDKDPERERDRERDVDREDRFRRPRDEGGWRRGPAEESSSWRDSSRRDDRDRDDRRRERDDRRDLRERRDLRDDRDRRGPPLRSEREEVSSWRRADDRKDDRVEERDPPRRVPPPALSRDRERDRDREREGEKEKASWRAEKDRESLRRTKNETDEDGWTTVRR
Repeat regions	REPEAT 925 934 1 REPEAT 935 942 2 REPEAT 943 952 3 REPEAT 953 962 4 REPEAT 963 972 5 REPEAT 973 982 6 REPEAT 983 992 7 REPEAT 993 1002 8 REPEAT 1003 1012 9 REPEAT 1013 1022 10 REPEAT 1023 1032 11 REPEAT 1033 1042 12 REPEAT 1043 1052 13 REPEAT 1054 1063 14 REPEAT 1064 1073 15 REPEAT 1074 1083 16 REPEAT 1084 1093 17 REPEAT 1094 1103 18 REPEAT 1104 1113 19 REPEAT 1114 1123 20 REPEAT 1124 1133 21 REPEAT 1134 1143 22 REPEAT 1144 1152 23 REPEAT 1153 1162 24 REPEAT 1163 1172 25 approximate
Sequence region of repeats	925- 934 DRSHRRDEER 935- 942 PRRLGDDE 943- 952 DREPSLRPDD 953- 962 DRVPRRGMDD 963- 972 DRGPRRGPEE 973- 982 DRFSRRGADD 983- 992 DRPSWRNTDD 993- 1002 DRPPRRIADE 1003- 1012 DRGNWRHADD 1013- 1022 DRPPRRGLDE 1023- 1032 DRGSWRTADE 1033- 1042 DRGPRRGMDD 1043- 1052 DRGPRRGGAD 1054- 1063 ERSSWRNADD 1064- 1073 DRGPRRGLDD 1074- 1083 DRGPRRGMDD 1084- 1093 DRGPRRGMDD 1094- 1103 DRGPRRGMDD 1104- 1113 DRGPRRGLDD 1114- 1123 DRGPWRNADD 1124- 1133 DRIPRRGAED 1134- 1143 DRGPWRNMDD 1144- 1152 DRLSRRADD 1153- 1162 DRFPRRGDDS 1163- 1172 RPGPWRPLVK - P
Domains	DOMAIN 315 498 PCI
Function	"RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis (PubMed:17581632, PubMed:25849773). The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation (PubMed:17581632, PubMed:11169732). The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression (PubMed:25849773, PubMed:27462815).; (Microbial infection) Essential for the initiation of translation on type-1 viral ribosomal entry sites (IRESs), like for HCV, PV, EV71 or BEV translation (PubMed:23766293, PubMed:24357634).; (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2 (PubMed:18056426)"
Mutation

Q14152 Proteins with OtherRepeats Repeats