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Q14738 Proteins with OtherRepeats Repeats

Uniprot ID: Q14738	Protein name : Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform	Gene : PPP2R5D
Protein Families : Phosphatase 2A regulatory subunit B56 family	Squence Length : 602

Sequence	>Q14738 603 MPYKLKKEKEPPKVAKCTAKPSSSGKDGGGENTEEAQPQPQPQPQPQAQSQPPSSNKRPSNSTPPPTQLSKIKYSGGPQIVKKERRQSSSRFNLSKNRELQKLPALKDSPTQEREELFIQKLRQCCVLFDFVSDPLSDLKFKEVKRAGLNEMVEYITHSRDVVTEAIYPEAVTMFSVNLFRTLPPSSNPTGAEFDPEEDEPTLEAAWPHLQLVYEFFLRFLESPDFQPNIAKKYIDQKFVLALLDLFDSEDPRERDFLKTILHRIYGKFLGLRAYIRRQINHIFYRFIYETEHHNGIAELLEILGSIINGFALPLKEEHKMFLIRVLLPLHKVKSLSVYHPQLAYCVVQFLEKESSLTEPVIVGLLKFWPKTHSPKEVMFLNELEEILDVIEPSEFSKVMEPLFRQLAKCVSSPHFQVAERALYYWNNEYIMSLISDNAARVLPIMFPALYRNSKSHWNKTIHGLIYNALKLFMEMNQKLFDDCTQQYKAEKQKGRFRMKEREEMWQKIEELARLNPQYPMFRAPPPLPPVYSMETETPTAEDIQLLKRTVETEAVQMLKDIKKEKVLLRRKSELPQDVYTIKALEAHKRAEEFLTASQEAL
Repeat regions	REPEAT 37 38 1 REPEAT 39 40 2 REPEAT 41 42 3 REPEAT 43 44 4 REPEAT 45 46 5 REPEAT 47 48 6 approximate REPEAT 49 50 7 approximate REPEAT 51 52 8
Sequence region of repeats	37- 38 QP 39- 40 QP 41- 42 QP 43- 44 QP 45- 46 QA 47- 48 QS - P 49- 50 QP - P 51- 52 PS
Function	"The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment"
Motifs	MOTIF 523 530 SH3-binding. class I. MOTIF 548 565 Nuclear localization signal
Mutation
Disease	"DISEASE: Mental retardation, autosomal dominant 35 (MRD35) [MIM:616355]: A form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period Note=The disease is caused by mutations affecting the gene represented in this entry"