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Q15532 Proteins with OtherRepeats Repeats

Uniprot ID: Q15532	Protein name : Protein SSXT	Gene : SS18 SSXT SYT
Protein Families : SS18 family	Squence Length : 418

Sequence	>Q15532 419 MSVAFAAPRQRGKGEITPAAIQKMLDDNNHLIQCIMDSQNKGKTSECSQYQQMLHTNLVYLATIADSNQNMQSLLPAPPTQNMPMGPGGMNQSGPPPPPRSHNMPSDGMVGGGPPAPHMQNQMNGQMPGPNHMPMQGPGPNQLNMTNSSMNMPSSSHGSMGGYNHSVPSSQSMPVQNQMTMSQGQPMGNYGPRPNMSMQPNQGPMMHQQPPSQQYNMPQGGGQHYQGQQPPMGMMGQVNQGNHMMGQRQIPPYRPPQQGPPQQYSGQEDYYGDQYSHGGQGPPEGMNQQYYPDGHNDYGYQQPSYPEQGYDRPYEDSSQHYYEGGNSQYGQQQDAYQGPPPQQGYPPQQQQYPGQQGYPGQQQGYGPSQGGPGPQYPNYPQGQGQQYGGYRPTQPGPPQPPQQRPYGYDQGQYGNYQQ
Repeat regions	REPEAT 344 356 1 REPEAT 357 369 2
Sequence region of repeats	344- 356 PPQQQQYPGQQGY 357- 369 PGQQQGYGPSQGG
Function	Appears to function synergistically with RBM14 as a transcriptional coactivator. Isoform 1 and isoform 2 function in nuclear receptor coactivation. Isoform 1 and isoform 2 function in general transcriptional coactivation
Motifs	MOTIF 50 53 SH2-binding. MOTIF 374 377 SH2-binding. MOTIF 392 401 SH3-binding. MOTIF 413 416 SH2-binding
Mutation
Disease	DISEASE: Note=A chromosomal aberration involving SS18 may be a cause of synovial sarcoma Translocation t(X;18)(p11 2;q11 2) The translocation is specifically found in more than 80% of synovial sarcoma The fusion products SSXT-SSX1 or SSXT-SSX2 are probably responsible for transforming activity Heterogeneity in the position of the breakpoint can occur (low frequency)