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Q6PGN9 Proteins with OtherRepeats Repeats
Uniprot ID: Q6PGN9
Protein name : Proline/serine-rich coiled-coil protein 1
Gene : PSRC1 DDA3 FP3214
Protein Families : PSRC1 family
Squence Length : 363
Sequence
>Q6PGN9 364 MEDLEEDVRFIVDETLDFGGLSPSDSREEEDITVLVTPEKPLRRGLSHRSDPNAVAPAPQGVRLSLGPLSPEKLEEILDEANRLAAQLEQCALQDRESAGEGLGPRRVKPSPRRETFVLKDSPVRDLLPTVNSLTRSTPSPSSLTPRLRSNDRKGSVRALRATSGKRPSNMKRESPTCNLFPASKSPASSPLTRSTPPVRGRAGPSGRAAASEETRAAKLRVSGSGEFVGLTLKFLHPSPPGPPTPIRSVLAPQPSTSNSQRLPRPQGAAAKSSSQLPIPSAIPRPASRMPLTSRSVPPGRGALPPDSLSTRKGLPRPSTAGHRVRESGHKVPVSQRLNLPVMGATRSNLQPPRKVAVPGPTR
Repeat regions
REPEAT 38 41 1 REPEAT 68 71 2 REPEAT 238 241 3 REPEAT 243 246 4
Sequence region of repeats
38- 41 KPLR 68- 71 SPEK 238- 241 PPGP 243- 246 TPIR
Function
"Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate, and for normal rate of chromosomal segregation during anaphase. Plays a role in the regulation of mitotic spindle dynamics. Increases the rate of turnover of microtubules on metaphase spindles, and contributes to the generation of normal tension across sister kinetochores. Recruits KIF2A and ANKRD53 to the mitotic spindle and spindle poles. May participate in p53/TP53-regulated growth suppression"
Mutation