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Q9NZD2 Proteins with OtherRepeats Repeats
Uniprot ID: Q9NZD2
Protein name : Glycolipid transfer protein
Gene : GLTP
Protein Families : GLTP family
Squence Length : 209
Sequence
>Q9NZD2 210 MALLAEHLLKPLPADKQIETGPFLEAVSHLPPFFDCLGSPVFTPIKADISGNITKIKAVYDTNPAKFRTLQNILEVEKEMYGAEWPKVGATLALMWLKRGLRFIQVFLQSICDGERDENHPNLIRVNATKAYEMALKKYHGWIVQKIFQAALYAAPYKSDFLKALSKGQNVTEEECLEKIRLFLVNYTATIDVIYEMYTQMNAELNYKV
Repeat regions
REPEAT 45 55 1 REPEAT 56 66 2
Sequence region of repeats
45- 55 ADISGNITKIK 56- 66 AVYDTNPAKFR
Function
Accelerates the intermembrane transfer of various glycolipids. Catalyzes the transfer of various glycosphingolipids between membranes but does not catalyze the transfer of phospholipids. May be involved in the intracellular translocation of glucosylceramides
Binding Site
BINDING 140 140 Glycolipid. BINDING 207 207 Glycolipid
Mutation
45 45 I->N: 18% decrease in activity 48 48 D->V: Significant inactivation 15% residual activity 52 52 N->I: Significant inactivation 15% residual activity 55 55 K->I: No loss of activity 90-97% residual activity 96 96 W->A: Almost complete inactivation 1-3% residual activity 96 96 W->F: Partial inactivation 63% residual activity 103 103 F->S: About 25% decrease in activity 136 136 L->R: Significant inactivation 5% residual acti vity 140 140 H->L: Almost complete inactivation 1-3% residual activity 148 148 F->S: About 50% decrease in activity 165 165 L->R: 46% decrease in activity 183 183 F->S: No loss of activity 90% residual activity 207 207 Y->L: No loss of activity 90-97% residual activity