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Q9UKF2 Proteins with OtherRepeats Repeats

Uniprot ID: Q9UKF2	Protein name : Disintegrin and metalloproteinase domain-containing protein 30	Gene : ADAM30 UNQ2509/PRO5997
Protein Families :	Squence Length : 790

Sequence	>Q9UKF2 791 MRSVQIFLSQCRLLLLLVPTMLLKSLGEDVIFHPEGEFDSYEVTIPEKLSFRGEVQGVVSPVSYLLQLKGKKHVLHLWPKRLLLPRHLRVFSFTEHGELLEDHPYIPKDCNYMGSVKESLDSKATISTCMGGLRGVFNIDAKHYQIEPLKASPSFEHVVYLLKKEQFGNQVCGLSDDEIEWQMAPYENKARLRDFPGSYKHPKYLELILLFDQSRYRFVNNNLSQVIHDAILLTGIMDTYFQDVRMRIHLKALEVWTDFNKIRVGYPELAEVLGRFVIYKKSVLNARLSSDWAHLYLQRKYNDALAWSFGKVCSLEYAGSVSTLLDTNILAPATWSAHELGHAVGMSHDEQYCQCRGRLNCIMGSGRTGFSNCSYISFFKHISSGATCLNNIPGLGYVLKRCGNKIVEDNEECDCGSTEECQKDRCCQSNCKLQPGANCSIGLCCHDCRFRPSGYVCRQEGNECDLAEYCDGNSSSCPNDVYKQDGTPCKYEGRCFRKGCRSRYMQCQSIFGPDAMEAPSECYDAVNLIGDQFGNCEITGIRNFKKCESANSICGRLQCINVETIPDLPEHTTIISTHLQAENLMCWGTGYHLSMKPMGIPDLGMINDGTSCGEGRVCFKKNCVNSSVLQFDCLPEKCNTRGVCNNRKNCHCMYGWAPPFCEEVGYGGSIDSGPPGLLRGAIPSSIWVVSIIMFRLILLILSVVFVFFRQVIGNHLKPKQEKMPLSKAKTEQEESKTKTVQEESKTKTGQEESEAKTGQEESKAKTGQEESKANIESKRPKAKSVKKQKK
Repeat regions	REPEAT 732 740 1 REPEAT 741 749 2 REPEAT 750 758 3 REPEAT 759 767 4 REPEAT 768 776 5
Sequence region of repeats	732- 740 ESKTKTVQE 741- 749 ESKTKTGQE 750- 758 ESEAKTGQE 759- 767 ESKAKTGQE 768- 776 ESKANIESK
Domains	DOMAIN 203 393 Peptidase M12B. DOMAIN 399 485 Disintegrin. DOMAIN 629 663 EGF-like
Function	Plays a role in lysosomal amyloid precursor protein (APP) processing by cleaving and activating CTSD/cathepsin D which leads to APP degradation (PubMed:27333034)
Active Site	ACT_SITE 339 339
Motifs	MOTIF 170 177 Cysteine switch
Mutation	338 338 H->L: Loss of enzymatic activity when associated with L-342 and L-348 342 342 H->L: Loss of enzymatic activity when associated with L-338 and L-348 348 348 H->L: Loss of enzymatic activity when associated with L-338 and L-342