S.NO	Uniprot ID	Protein Name	Sequence Length	C2 Repeated Region	Function
1	Q8IYJ1	Copine-9	553	DOMAIN 1 107 C2 1 DOMAIN 134 239 C2 2	Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003).
2	Q9HCH5	Synaptotagmin-like protein 2	934	DOMAIN 629 733 C2 1 DOMAIN 778 880 C2 2	"Isoform 1 acts as a RAB27A effector protein and plays a role in cytotoxic granule exocytosis in lymphocytes. It is required for cytotoxic granule docking at the immunologic synapse. Isoform 4 binds phosphatidylserine (PS) and phosphatidylinositol-4,5-bisphosphate (PIP2) and promotes the recruitment of glucagon-containing granules to the cell membrane in pancreatic alpha cells. Binding to PS is inhibited by Ca(2+) while binding to PIP2 is Ca(2+) insensitive".
3	O14795	Protein unc-13 homolog B	1591	DOMAIN 1 79 C2 1 DOMAIN 587 693 C2 2 DOMAIN 1425 1530 C2 3	Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Is involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-depending refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in a subset of excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity).
4	Q9UPW8	Protein unc-13 homolog A	1703	DOMAIN 1 79 C2 1 DOMAIN 663 769 C2 2 DOMAIN 1532 1637 C2 3	Plays a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. Involved in neurotransmitter release by acting in synaptic vesicle priming prior to vesicle fusion and participates in the activity-dependent refilling of readily releasable vesicle pool (RRP). Essential for synaptic vesicle maturation in most excitatory/glutamatergic but not inhibitory/GABA-mediated synapses (By similarity). Also involved in secretory granule priming in insulin secretion (By similarity). Interacts with FBXO45 (via SRY domain); leading to the degradation of UNC13A by the proteasome (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003).
5	A0AVI2	Fer-1-like protein 5	2057	DOMAIN 1 83 C2 1 DOMAIN 168 249 C2 2 DOMAIN 327 408 C2 3 DOMAIN 1063 1168 C2 4 DOMAIN 1488 1571 C2 5 DOMAIN 1706 1836 C2 6	Plays a role in myoblast fusion; probable mediator of endocytic recycling for membrane trafficking events during myotube formation.
6	Q9NZM1	Myoferlin	2061	DOMAIN 1 85 C2 1 DOMAIN 186 281 C2 2 DOMAIN 345 458 C2 3 DOMAIN 1126 1231 C2 4 DOMAIN 1538 1638 C2 5	Calcium/phospholipid-binding protein that plays a role in the plasmalemma repair mechanism of endothelial cells that permits rapid resealing of membranes disrupted by mechanical stress. Involved in endocytic recycling. Implicated in VEGF signal transduction by regulating the levels of the receptor KDR (By similarity).
7	O75923	Dysferlin	2080	DOMAIN 1 85 C2 1 DOMAIN 207 302 C2 2 DOMAIN 366 479 C2 3 DOMAIN 1139 1244 C2 4 DOMAIN 1336 1423 C2 5 DOMAIN 1565 1663 C2 6 DOMAIN 1813 1926 C2 7	Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress (By similarity).
8	O95294	RasGAP-activating-like protein 1	804	DOMAIN 1 88 C2 1 DOMAIN 120 216 C2 2	Probable inhibitory regulator of the Ras-cyclic AMP pathway (PubMed:9751798). Plays a role in dendrite formation by melanocytes (PubMed:23999003).
9	C9J798	Ras GTPase-activating protein 4B	803	DOMAIN 1 88 C2 1 DOMAIN 120 216 C2 2	"Ca(2+)-dependent Ras GTPase-activating protein, that may play a role in the Ras-MAPK pathway".
10	O43374	Ras GTPase-activating protein 4	803	DOMAIN 1 88 C2 1 DOMAIN 129 216 C2 2	"Ca(2+)-dependent Ras GTPase-activating protein, that switches off the Ras-MAPK pathway following a stimulus that elevates intracellular calcium. Functions as an adaptor for Cdc42 and Rac1 during FcR-mediated phagocytosis".
11	Q14644	Ras GTPase-activating protein 3	834	DOMAIN 1 96 C2 1 DOMAIN 132 247 C2 2	Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4) with high affinity. Might be a specific IP4 receptor.
12	Q99829	Copine-1	537	DOMAIN 1 98 C2 1 DOMAIN 144 228 C2 2	"Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes (PubMed:14674885). Involved in the TNF-alpha receptor signaling pathway in a calcium-dependent manner (PubMed:14674885). Exhibits calcium-dependent phospholipid binding properties (PubMed:9430674, PubMed:19539605). Plays a role in neuronal progenitor cell differentiation; induces neurite outgrowth via a AKT-dependent signaling cascade and calcium-independent manner (PubMed:23263657, PubMed:25450385). May recruit target proteins to the cell membrane in a calcium-dependent manner (PubMed:12522145). May function in membrane trafficking (PubMed:9430674). Involved in TNF-alpha-induced NF-kappa-B transcriptional repression by inducing endoprotease processing of the transcription factor NF-kappa-B p65/RELA subunit (PubMed:18212740). Also induces endoprotease processing of NF-kappa-B p50/NFKB1, p52/NFKB2, RELB and REL (PubMed:18212740)".
13	Q96FN4	Copine-2	548	DOMAIN 10 115 C2 1 DOMAIN 141 246 C2 2	Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Exhibits calcium-dependent cell membrane binding properties.
14	Q86YQ8	Copine-8	564	DOMAIN 10 117 C2 1 DOMAIN 144 249 C2 2	Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes.
15	A0FGR9	Extended synaptotagmin-3	886	DOMAIN 293 392 C2 1 DOMAIN 430 544 C2 2 DOMAIN 756 860 C2 3	Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane.
16	Q4AC94	C2 domain-containing protein 3	2353	DOMAIN 1163 1289 C2 1 DOMAIN 1622 1728 C2 2	"Component of the centrioles that acts as a positive regulator of centriole elongation (PubMed:24997988). Promotes assembly of centriolar distal appendage, a structure at the distal end of the mother centriole that acts as an anchor of the cilium, and is required for recruitment of centriolar distal appendages proteins CEP83, SCLT1, CEP89, FBF1 and CEP164. Not required for centriolar satellite integrity or RAB8 activation. Required for primary cilium formation (PubMed:23769972). Required for sonic hedgehog/SHH signaling and for proteolytic processing of GLI3".
17	Q8NBV8	Synaptotagmin-8	401	DOMAIN 119 217 C2 1 DOMAIN 247 346 C2 2	Isoform 4 may play a role in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Mediates Ca(2+)-regulation of exocytosis acrosomal reaction in sperm. May mediate Ca(2+)-regulation of exocytosis in insulin secreted cells (By similarity).
18	Q8NB66	Protein unc-13 homolog C	2214	DOMAIN 1207 1313 C2 1 DOMAIN 2048 2153 C2 2	May play a role in vesicle maturation during exocytosis as a target of the diacylglycerol second messenger pathway. May be involved in the regulation of synaptic transmission at parallel fiber - Purkinje cell synapses (By similarity).
19	O00445	Synaptotagmin-5	386	DOMAIN 124 211 C2 1 DOMAIN 253 344 C2 2	May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. Regulates the Ca(2+)-dependent secretion of norepinephrine in PC12 cells. Required for export from the endocytic recycling compartment to the cell surface (By similarity).
20	Q14184	Double C2-like domain-containing protein beta	412	DOMAIN 128 232 C2 1 DOMAIN 268 371 C2 2	Calcium sensor which positively regulates SNARE-dependent fusion of vesicles with membranes. Binds phospholipids in a calcium-dependent manner and may act at the priming stage of fusion by modifying membrane curvature to stimulate fusion. Involved in calcium-triggered exocytosis in chromaffin cells and calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Involved both in glucose-stimulated insulin secretion in pancreatic cells and insulin-dependent GLUT4 transport to the plasma membrane in adipocytes (By similarity).
21	Q9BSJ8	Extended synaptotagmin-1	1104	DOMAIN 316 417 C2 1 DOMAIN 465 558 C2 2 DOMAIN 634 735 C2 3 DOMAIN 785 877 C2 4 DOMAIN 972 1077 C2 5	Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport (By similarity). Binds calcium (via the C2 domains) and translocates to sites of contact between the endoplasmic reticulum and the cell membrane in response to increased cytosolic calcium levels. Helps tether the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane.
22	O43581	Synaptotagmin-7	403	DOMAIN 137 239 C2 1 DOMAIN 268 371 C2 2	"Ca(2+) sensor involved in Ca(2+)-dependent exocytosis of secretory and synaptic vesicles through Ca(2+) and phospholipid binding to the C2 domain (By similarity). Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity). SYT7 binds Ca(2+) with high affinity and slow kinetics compared to other synaptotagmins (By similarity). Involved in Ca(2+)-triggered lysosomal exocytosis, a major component of the plasma membrane repair (PubMed:11342594). Ca(2+)-regulated delivery of lysosomal membranes to the cell surface is also involved in the phagocytic uptake of particles by macrophages (By similarity). Ca(2+)-triggered lysosomal exocytosis also plays a role in bone remodeling by regulating secretory pathways in osteoclasts and osteoblasts (By similarity). In case of infection, involved in participates cell invasion by Trypanosoma cruzi via Ca(2+)-triggered lysosomal exocytosis (PubMed:11342594, PubMed:15811535). Involved in cholesterol transport from lysosome to peroxisome by promoting membrane contacts between lysosomes and peroxisomes: probably acts by promoting vesicle fusion by binding phosphatidylinositol-4,5-bisphosphate on peroxisomal membranes (By similarity). Acts as a key mediator of synaptic facilitation, a process also named short-term synaptic potentiation: synaptic facilitation takes place at synapses with a low initial release probability and is caused by influx of Ca(2+) into the axon terminal after spike generation, increasing the release probability of neurotransmitters (By similarity). Probably mediates synaptic facilitation by directly increasing the probability of release (By similarity). May also contribute to synaptic facilitation by regulating synaptic vesicle replenishment, a process required to ensure that synaptic vesicles are ready for the arrival of the next action potential: SYT7 is required for synaptic vesicle replenishment by acting as a sensor for Ca(2+) and by forming a complex with calmodulin (By similarity). Also acts as a regulator of Ca(2+)-dependent insulin and glucagon secretion in beta-cells (By similarity). Triggers exocytosis by promoting fusion pore opening and fusion pore expansion in chromaffin cells (By similarity). Also regulates the secretion of some non-synaptic secretory granules of specialized cells (By similarity)".
23	Q8N9I0	Synaptotagmin-2	419	DOMAIN 141 242 C2 1 DOMAIN 272 375 C2 2	Exhibits calcium-dependent phospholipid and inositol polyphosphate binding properties (By similarity). May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003).
24	Q9BQS2	Synaptotagmin-15	421	DOMAIN 149 248 C2 1 DOMAIN 280 383 C2 2	May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues.
25	Q9H2B2	Synaptotagmin-4	425	DOMAIN 155 258 C2 1 DOMAIN 289 392 C2 2	May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003).
26	P21579	Synaptotagmin-1	422	DOMAIN 157 245 C2 1 DOMAIN 287 378 C2 2	"May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone. A Ca(2+)-dependent interaction between synaptotagmin and putative receptors for activated protein kinase C has also been reported. It can bind to at least three additional proteins in a Ca(2+)-independent manner; these are neurexins, syntaxin and AP2. Plays a role in dendrite formation by melanocytes (PubMed:23999003)".
27	Q8IV01	Synaptotagmin-12	421	DOMAIN 168 272 C2 1 DOMAIN 285 388 C2 2	May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis.
28	Q9BT88	Synaptotagmin-11	431	DOMAIN 174 262 C2 1 DOMAIN 304 397 C2 2	May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis.
29	Q7L8C5	Synaptotagmin-13	426	DOMAIN 175 259 C2 1 DOMAIN 289 394 C2 2	May be involved in transport vesicle docking to the plasma membrane.
30	Q6DN12	Multiple C2 and transmembrane domain-containing protein 2	878	DOMAIN 181 276 C2 1 DOMAIN 343 436 C2 2 DOMAIN 496 591 C2 3	Might play a role in the development of cardiac outflow tract.
31	O94812	BAI1-associated protein 3	1187	DOMAIN 182 317 C2 1 DOMAIN 1012 1119 C2 2	"Functions in endosome to Golgi retrograde transport. In response to calcium influx, may interact with SNARE fusion receptors and membrane phospholipids to mediate endosome fusion with the trans-Golgi network. By promoting the recycling of secretory vesicle transmembrane proteins, it indirectly controls dense-core secretory vesicle biogenesis, maturation and their ability to mediate the constitutive and regulated secretion of neurotransmitters and hormones. May regulate behavior and food intake by controlling calcium-stimulated exocytosis of neurotransmitters including NPY and serotonin and hormones like insulin (PubMed:28626000). Proposed to play a role in hypothalamic neuronal firing by modulating gamma-aminobutyric acid (GABA)ergic inhibitory neurotransmission (By similarity)".
32	Q9BSW7	Synaptotagmin-17	474	DOMAIN 186 294 C2 1 DOMAIN 323 426 C2 2	Plays a role in dendrite formation by melanocytes (PubMed:23999003).
33	A0FGR8	Extended synaptotagmin-2	921	DOMAIN 372 473 C2 1 DOMAIN 523 617 C2 2 DOMAIN 788 892 C2 3	Tethers the endoplasmic reticulum to the cell membrane and promotes the formation of appositions between the endoplasmic reticulum and the cell membrane. Binds glycerophospholipids in a barrel-like domain and may play a role in cellular lipid transport. Plays a role in FGF signaling via its role in the rapid internalization of FGFR1 that has been activated by FGF1 binding; this occurs most likely via the AP-2 complex.
34	O75131	Copine-3	537	DOMAIN 2 99 C2 1 DOMAIN 125 230 C2 2	Calcium-dependent phospholipid-binding protein that plays a role in ERBB2-mediated tumor cell migration in response to growth factor heregulin stimulation (PubMed:20010870).
35	Q86UR5	Regulating synaptic membrane exocytosis protein 1	1692	DOMAIN 744 850 C2 1 DOMAIN 1538 1640 C2 2	Rab effector involved in exocytosis (By similarity). May act as scaffold protein that regulates neurotransmitter release at the active zone. Essential for maintaining normal probability of neurotransmitter release and for regulating release during short-term synaptic plasticity (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003).
36	Q86SS6	Synaptotagmin-9	491	DOMAIN 222 323 C2 1 DOMAIN 354 457 C2 2	May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis.
37	Q5T7P8	Synaptotagmin-6	510	DOMAIN 231 332 C2 1 DOMAIN 363 466 C2 2	May be involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain or may serve as Ca(2+) sensors in the process of vesicular trafficking and exocytosis. May mediate Ca(2+)-regulation of exocytosis in acrosomal reaction in sperm (By similarity).
38	Q6XYQ8	Synaptotagmin-10	523	DOMAIN 233 334 C2 1 DOMAIN 365 468 C2 2	Ca(2+) sensor specifically required for the Ca(2+)-dependent exocytosis of secretory vesicles containing IGF1 in neurons of the olfactory bulb. Exocytosis of IGF1 is required for sensory perception of smell. Not involved in Ca(2+)-dependent synaptic vesicle exocytosis (By similarity). Acts through Ca(2+) and phospholipid binding to the C2 domain: Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity).
39	O95741	Copine-6	557	DOMAIN 24 111 C2 1 DOMAIN 138 243 C2 2	Calcium-dependent phospholipid-binding protein that plays a role in calcium-mediated intracellular processes. Binds phospholipid membranes in a calcium-dependent manner (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003).
40	Q96A23	Copine-4	557	DOMAIN 24 130 C2 1 DOMAIN 141 246 C2 2	Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes.
41	Q9HC10	Otoferlin	1997	DOMAIN 241 338 C2 1 DOMAIN 404 514 C2 2 DOMAIN 947 1052 C2 3 DOMAIN 1479 1577 C2 4	Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion and in the control of neurotransmitter release at these output synapses. Interacts in a calcium-dependent manner to the presynaptic SNARE proteins at ribbon synapses of cochlear inner hair cells (IHCs) to trigger exocytosis of neurotransmitter. Also essential to synaptic exocytosis in immature outer hair cells (OHCs). May also play a role within the recycling of endosomes (By similarity).
42	Q6DN14	Multiple C2 and transmembrane domain-containing protein 1	999	DOMAIN 248 344 C2 1 DOMAIN 457 553 C2 2 DOMAIN 613 708 C2 3	Calcium sensor which is essential for the stabilization of normal baseline neurotransmitter release and for the induction and long-term maintenance of presynaptic homeostatic plasticity.
43	Q15283	Ras GTPase-activating protein 2	850	DOMAIN 25 122 C2 1 DOMAIN 158 273 C2 2	Inhibitory regulator of the Ras-cyclic AMP pathway. Binds inositol tetrakisphosphate (IP4).
44	Q9UQ26	Regulating synaptic membrane exocytosis protein 2	1411	DOMAIN 807 913 C2 1 DOMAIN 1257 1359 C2 2	Rab effector involved in exocytosis. May act as scaffold protein. Plays a role in dendrite formation by melanocytes (PubMed:23999003).
45	Q8NB59	Synaptotagmin-14	555	DOMAIN 276 378 C2 1 DOMAIN 417 521 C2 2	May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Is Ca(2+)-independent.
46	Q9UBL6	Copine-7	633	DOMAIN 28 114 C2 1 DOMAIN 237 321 C2 2	Calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes.
47	Q9HCH3	Copine-5	593	DOMAIN 29 116 C2 1 DOMAIN 147 268 C2 2	Probable calcium-dependent phospholipid-binding protein that may play a role in calcium-mediated intracellular processes (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003).
48	Q9BQG1	Synaptotagmin-3	590	DOMAIN 301 402 C2 1 DOMAIN 433 536 C2 2	Ca(2+) sensor involved in Ca(2+)-dependent exocytosis of secretory vesicles through Ca(2+) and phospholipid binding to the C2 domain. Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis (By similarity). Plays a role in dendrite formation by melanocytes (PubMed:23999003).
49	Q8IYJ3	Synaptotagmin-like protein 1	562	DOMAIN 268 368 C2 1 DOMAIN 409 511 C2 2	"May play a role in vesicle trafficking (By similarity). Binds phosphatidylinositol 3,4,5-trisphosphate. Acts as a RAB27A effector protein and may play a role in cytotoxic granule exocytosis in lymphocytes (By similarity)".
50	Q17RD7	Synaptotagmin-16	645	DOMAIN 352 453 C2 1 DOMAIN 507 611 C2 2	May be involved in the trafficking and exocytosis of secretory vesicles in non-neuronal tissues. Is Ca(2+)-independent.
51	Q96C24	Synaptotagmin-like protein 4	671	DOMAIN 358 462 C2 1 DOMAIN 513 617 C2 2	Modulates exocytosis of dense-core granules and secretion of hormones in the pancreas and the pituitary. Interacts with vesicles containing negatively charged phospholipids in a Ca(2+)-independent manner (By similarity).
52	Q4VX76	Synaptotagmin-like protein 3	610	DOMAIN 308 412 C2 1 DOMAIN 467 571 C2 2	May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids in the presence of calcium ions (By similarity).
53	Q9Y2J0	Rabphilin-3A	694	DOMAIN 394 498 C2 1 DOMAIN 552 655 C2 2	Protein transport. Probably involved with Ras-related protein Rab-3A in synaptic vesicle traffic and/or synaptic vesicle fusion. Could play a role in neurotransmitter release by regulating membrane flow in the nerve terminal (By similarity).
54	Q9Y6V0	Protein piccolo	5142	DOMAIN 4677 4807 C2 1 DOMAIN 5011 5116 C2 2	May act as a scaffolding protein involved in the organization of synaptic active zones and in synaptic vesicle trafficking.
55	Q68CZ1	Protein fantom	1315	DOMAIN 615 712 C2 1 DOMAIN 777 881 C2 2	"Negatively regulates signaling through the G-protein coupled thromboxane A2 receptor (TBXA2R) (PubMed:19464661). May be involved in mechanisms like programmed cell death, craniofacial development, patterning of the limbs, and formation of the left-right axis (By similarity). Involved in the organization of apical junctions; the function is proposed to implicate a NPHP1-4-8 module. Does not seem to be strictly required for ciliogenesis (PubMed:19464661). Involved in establishment of planar cell polarity such as in cochlear sensory epithelium and is proposed to implicate stabilization of disheveled proteins (By similarity). Involved in regulation of proteasomal activity at the primary cilium probably implicating association with PSDM2 (By similarity)".
56	Q8TDW5	Synaptotagmin-like protein 5	730	DOMAIN 408 511 C2 1 DOMAIN 574 678 C2 2	May act as Rab effector protein and play a role in vesicle trafficking. Binds phospholipids.
57	Q14183	Double C2-like domain-containing protein alpha	400	DOMAIN 91 195 C2 1 DOMAIN 253 356 C2 2	Calcium sensor which most probably regulates fusion of vesicles with membranes. Binds calcium and phospholipids. May be involved in calcium dependent neurotransmitter release through the interaction with UNC13A. May be involved in calcium-dependent spontaneous release of neurotransmitter in absence of action potentials in neuronal cells. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells.
58	Q70J99	Protein unc-13 homolog D	1090	DOMAIN 98 221 C2 1 DOMAIN 912 1019 C2 2	"Plays a role in cytotoxic granule exocytosis in lymphocytes. Required for both granule maturation and granule docking and priming at the immunologic synapse. Regulates assembly of recycling and late endosomal structures, leading to the formation of an endosomal exocytic compartment that fuses with perforin-containing granules at the immunologic synapse and licences them for exocytosis. Regulates Ca(2+)-dependent secretory lysosome exocytosis in mast cells".

The 58 function of C2 of the protein