S.NO	Uniprot ID	Protein Name	Sequence Length	CUB Repeated Region	Function
1	Q9UGM3	Deleted in malignant brain tumors 1 protein	2413	DOMAIN 1766 1877 CUB 1 DOMAIN 2008 2117 CUB 2	"May be considered as a candidate tumor suppressor gene for brain, lung, esophageal, gastric, and colorectal cancers. May play roles in mucosal defense system, cellular immune defense and epithelial differentiation. May play a role as an opsonin receptor for SFTPD and SPAR in macrophage tissues throughout the body, including epithelial cells lining the gastrointestinal tract. May play a role in liver regeneration. May be an important factor in fate decision and differentiation of transit-amplifying ductular (oval) cells within the hepatic lineage. Required for terminal differentiation of columnar epithelial cells during early embryogenesis. May function as a binding protein in saliva for the regulation of taste sensation. Binds to HIV-1 envelope protein and has been shown to both inhibit and facilitate viral transmission. Displays a broad calcium-dependent binding spectrum against both Gram-positive and Gram-negative bacteria, suggesting a role in defense against bacterial pathogens. Binds to a range of poly-sulfated and poly-phosphorylated ligands which may explain its broad bacterial-binding specificity. Inhibits cytoinvasion of S. enterica. Associates with the actin cytoskeleton and is involved in its remodeling during regulated exocytosis. Interacts with pancreatic zymogens in a pH-dependent manner and may act as a Golgi cargo receptor in the regulated secretory pathway of the pancreatic acinar cell".
2	Q7RTY8	Transmembrane protease serine 7	843	DOMAIN 247 360 CUB 1 DOMAIN 365 481 CUB 2	Serine protease which preferentially hydrolyzes peptides with Arg at the P1 position.
3	P13497	Bone morphogenetic protein 1	986	DOMAIN 322 434 CUB 1 DOMAIN 435 546 CUB 2 DOMAIN 591 703 CUB 3 DOMAIN 747 859 CUB 4 DOMAIN 860 976 CUB 5	"Cleaves the C-terminal propeptides of procollagen I, II and III. Induces cartilage and bone formation. May participate in dorsoventral patterning during early development by cleaving chordin (CHRD). Responsible for the proteolytic activation of lysyl oxidase LOX".
4	O60494	Cubilin	3623	DOMAIN 474 586 CUB 1 DOMAIN 590 702 CUB 2 DOMAIN 708 816 CUB 3 DOMAIN 816 928 CUB 4 DOMAIN 932 1042 CUB 5 DOMAIN 1048 1161 CUB 6 DOMAIN 1165 1277 CUB 7 DOMAIN 1278 1389 CUB 8 DOMAIN 1391 1506 CUB 9 DOMAIN 1510 1619 CUB 10 DOMAIN 1620 1734 CUB 11 DOMAIN 1738 1850 CUB 12 DOMAIN 1852 1963 CUB 13 DOMAIN 1978 2091 CUB 14 DOMAIN 2092 2213 CUB 15 DOMAIN 2217 2334 CUB 16 DOMAIN 2336 2448 CUB 17 DOMAIN 2452 2565 CUB 18 DOMAIN 2570 2687 CUB 19 DOMAIN 2689 2801 CUB 20 DOMAIN 2805 2919 CUB 21 DOMAIN 2920 3035 CUB 22 DOMAIN 3037 3150 CUB 23 DOMAIN 3157 3274 CUB 24 DOMAIN 3278 3393 CUB 25 DOMAIN 3395 3507 CUB 26 DOMAIN 3511 3623 CUB 27	"Cotransporter which plays a role in lipoprotein, vitamin and iron metabolism, by facilitating their uptake. Binds to ALB, MB, Kappa and lambda-light chains, TF, hemoglobin, GC, SCGB1A1, APOA1, high density lipoprotein, and the GIF-cobalamin complex. The binding of all ligands requires calcium. Serves as important transporter in several absorptive epithelia, including intestine, renal proximal tubules and embryonic yolk sac. Interaction with LRP2 mediates its trafficking throughout vesicles and facilitates the uptake of specific ligands like GC, hemoglobin, ALB, TF and SCGB1A1. Interaction with AMN controls its trafficking to the plasma membrane and facilitates endocytosis of ligands. May play an important role in the development of the peri-implantation embryo through internalization of APOA1 and cholesterol. Binds to LGALS3 at the maternal-fetal interface".
5	Q9BY79	Membrane frizzled-related protein	579	DOMAIN 144 253 CUB 1 DOMAIN 301 414 CUB 2	May play a role in eye development.
6	O43897	Tolloid-like protein 1	1013	DOMAIN 349 461 CUB 1 DOMAIN 462 574 CUB 2 DOMAIN 618 730 CUB 3 DOMAIN 774 886 CUB 4 DOMAIN 887 1003 CUB 5	"Protease which processes procollagen C-propeptides, such as chordin, pro-biglycan and pro-lysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis".
7	Q9Y6L7	Tolloid-like protein 2	1015	DOMAIN 351 463 CUB 1 DOMAIN 464 576 CUB 2 DOMAIN 620 732 CUB 3 DOMAIN 776 888 CUB 4 DOMAIN 889 1005 CUB 5	"Protease which specifically processes pro-lysyl oxidase. Required for the embryonic development. Predominant protease, which in the development, influences dorsal-ventral patterning and skeletogenesis".
8	P09871	Complement C1s subcomponent	688	DOMAIN 16 130 CUB 1 DOMAIN 175 290 CUB 2	"C1s B chain is a serine protease that combines with C1q and C1r to form C1, the first component of the classical pathway of the complement system. C1r activates C1s so that it can, in turn, activate C2 and C4".
9	O00187	Mannan-binding lectin serine protease 2	686	DOMAIN 16 137 CUB 1 DOMAIN 184 296 CUB 2	"Serum protease that plays an important role in the activation of the complement system via mannose-binding lectin. After activation by auto-catalytic cleavage it cleaves C2 and C4, leading to their activation and to the formation of C3 convertase".
10	Q6UXD5	Seizure 6-like protein 2	910	DOMAIN 173 286 CUB 1 DOMAIN 349 459 CUB 2 DOMAIN 527 638 CUB 3	May contribute to specialized endoplasmic reticulum functions in neurons.
11	P00736	Complement C1r subcomponent	705	DOMAIN 18 141 CUB 1 DOMAIN 193 305 CUB 2	"C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system".
12	P48740	Mannan-binding lectin serine protease 1	699	DOMAIN 20 138 CUB 1 DOMAIN 185 297 CUB 2	"Functions in the lectin pathway of complement, which performs a key role in innate immunity by recognizing pathogens through patterns of sugar moieties and neutralizing them. The lectin pathway is triggered upon binding of mannan-binding lectin (MBL) and ficolins to sugar moieties which leads to activation of the associated proteases MASP1 and MASP2. Functions as an endopeptidase and may activate MASP2 or C2 or directly activate C3 the key component of complement reaction. Isoform 2 may have an inhibitory effect on the activation of the lectin pathway of complement or may cleave IGFBP5. Also plays a role in development (PubMed:21258343)".
13	Q86UP6	CUB and zona pellucida-like domain-containing protein 1	607	DOMAIN 25 146 CUB 1 DOMAIN 154 265 CUB 2	CUZD1 antiserum inhibits cell attachment and proliferation of ovarian cancer cells so may be involved in these processes. May also play a role in the uterus during late pregnancy and/or in trypsin activation in pancreatic acinar cells.
14	O14786	Neuropilin-1	923	DOMAIN 27 141 CUB 1 DOMAIN 147 265 CUB 2	"The membrane-bound isoform 1 is a receptor involved in the development of the cardiovascular system, in angiogenesis, in the formation of certain neuronal circuits and in organogenesis outside the nervous system. It mediates the chemorepulsant activity of semaphorins. It binds to semaphorin 3A, The PLGF-2 isoform of PGF, The VEGF165 isoform of VEGFA and VEGFB. Coexpression with KDR results in increased VEGF165 binding to KDR as well as increased chemotaxis. Regulate VEGF-induced angiogenesis. Binding to VEGFA initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By similarity). ; The soluble isoform 2 binds VEGF-165 and appears to inhibit its binding to cells. It may also induce apoptosis by sequestering VEGF-165. May bind as well various members of the semaphorin family. Its expression has an averse effect on blood vessel number and integrity".
15	Q7Z4F1	Low-density lipoprotein receptor-related protein 10	713	DOMAIN 28 136 CUB 1 DOMAIN 192 305 CUB 2	"Probable receptor, which is involved in the internalization of lipophilic molecules and/or signal transduction. May be involved in the uptake of lipoprotein APOE in liver (By similarity)".
16	O60462	Neuropilin-2	931	DOMAIN 28 142 CUB 1 DOMAIN 149 267 CUB 2	"High affinity receptor for semaphorins 3C, 3F, VEGF-165 and VEGF-145 isoforms of VEGF, and the PLGF-2 isoform of PGF".
17	Q9BYH1	Seizure 6-like protein	1024	DOMAIN 281 389 CUB 1 DOMAIN 452 562 CUB 2 DOMAIN 628 739 CUB 3	May contribute to specialized endoplasmic reticulum functions in neurons.
18	Q7Z7M0	Multiple epidermal growth factor-like domains protein 8	2845	DOMAIN 30 140 CUB 1 DOMAIN 1263 1405 CUB 2	Acts as a negative regulator of hedgehog signaling.
19	Q96PZ7	CUB and sushi domain-containing protein 1	3564	DOMAIN 32 140 CUB 1 DOMAIN 208 312 CUB 2 DOMAIN 411 522 CUB 3 DOMAIN 584 692 CUB 4 DOMAIN 758 866 CUB 5 DOMAIN 930 1040 CUB 6 DOMAIN 1104 1212 CUB 7 DOMAIN 1277 1386 CUB 8 DOMAIN 1451 1559 CUB 9 DOMAIN 1625 1733 CUB 10 DOMAIN 1802 1910 CUB 11 DOMAIN 1974 2082 CUB 12 DOMAIN 2146 2257 CUB 13 DOMAIN 2319 2430 CUB 14	Potential suppressor of squamous cell carcinomas.
20	Q9UKZ9	Procollagen C-endopeptidase enhancer 2	415	DOMAIN 33 144 CUB 1 DOMAIN 154 268 CUB 2	Binds to the C-terminal propeptide of types I and II procollagens and may enhance the cleavage of that propeptide by BMP1.
21	Q53EL9	Seizure protein 6 homolog	994	DOMAIN 416 527 CUB 1 DOMAIN 593 704 CUB 2	May play a role in cell-cell recognition and in neuronal membrane signaling. Seems to be important for the achievement of the necessary balance between dendrite elongation and branching during the elaboration of a complex dendritic arbor. Involved in the development of appropriate excitatory synaptic connectivity (By similarity).
22	Q15113	Procollagen C-endopeptidase enhancer 1	449	DOMAIN 37 149 CUB 1 DOMAIN 159 273 CUB 2	Binds to the C-terminal propeptide of type I procollagen and enhances procollagen C-proteinase activity. ; C-terminal processed part of PCPE (CT-PCPE) may have an metalloproteinase inhibitory activity.
23	Q8TDF5	Neuropilin and tolloid-like protein 1	533	DOMAIN 41 155 CUB 1 DOMAIN 172 287 CUB 2	"Involved in the development and/or maintenance of neuronal circuitry. Accessory subunit of the neuronal N-methyl-D-aspartate receptor (NMDAR) critical for maintaining the abundance of GRIN2A-containing NMDARs in the postsynaptic density. Regulates long-term NMDA receptor-dependent synaptic plasticity and cognition, at least in the context of spatial learning and memory (By similarity)".
24	O75074	Low-density lipoprotein receptor-related protein 3	770	DOMAIN 43 159 CUB 1 DOMAIN 254 365 CUB 2	"Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. Its precise role is however unclear, since it does not bind to very low density lipoprotein (VLDL) or to LRPAP1 in vitro".
25	Q8NC67	Neuropilin and tolloid-like protein 2	525	DOMAIN 45 159 CUB 1 DOMAIN 177 292 CUB 2	"Accessory subunit of neuronal kainate-sensitive glutamate receptors, GRIK2 and GRIK3. Increases kainate-receptor channel activity, slowing the decay kinetics of the receptors, without affecting their expression at the cell surface, and increasing the open probability of the receptor channels. Modulates the agonist sensitivity of kainate receptors. Slows the decay of kainate receptor-mediated excitatory postsynaptic currents (EPSCs), thus directly influencing synaptic transmission (By similarity)".
26	Q9Y561	Low-density lipoprotein receptor-related protein 12	859	DOMAIN 47 159 CUB 1 DOMAIN 259 372 CUB 2	"Probable receptor, which may be involved in the internalization of lipophilic molecules and/or signal transduction. May act as a tumor suppressor".
27	P98073	Enteropeptidase	1019	DOMAIN 225 334 CUB 1 DOMAIN 524 634 CUB 2	"Responsible for initiating activation of pancreatic proteolytic proenzymes (trypsin, chymotrypsin and carboxypeptidase A). It catalyzes the conversion of trypsinogen to trypsin which in turn activates other proenzymes including chymotrypsinogen, procarboxypeptidases, and proelastases".
28	Q7Z407	CUB and sushi domain-containing protein 3	3707	DOMAIN 65 173 CUB 1 DOMAIN 241 345 CUB 2 DOMAIN 548 659 CUB 3 DOMAIN 721 829 CUB 4 DOMAIN 895 1003 CUB 5 DOMAIN 1067 1177 CUB 6 DOMAIN 1241 1349 CUB 7 DOMAIN 1414 1523 CUB 8 DOMAIN 1588 1696 CUB 9 DOMAIN 1762 1870 CUB 10 DOMAIN 1939 2047 CUB 11 DOMAIN 2111 2219 CUB 12 DOMAIN 2283 2394 CUB 13 DOMAIN 2456 2567 CUB 14	Involved in dendrite development.
29	Q76LX8	A disintegrin and metalloproteinase with thrombospondin motifs 13	1427	DOMAIN 1192 1298 CUB 1 DOMAIN 1299 1427 CUB 2	Cleaves the vWF multimers in plasma into smaller forms thereby controlling vWF-mediated platelet thrombus formation.
30	Q8IU80	Transmembrane protease serine 6	811	DOMAIN 213 336 CUB 1 DOMAIN 335 452 CUB 2	"Serine protease which hydrolyzes a range of proteins including type I collagen, fibronectin and fibrinogen. Can also activate urokinase-type plasminogen activator with low efficiency. May play a specialized role in matrix remodeling processes in liver. Through the cleavage of HFE2, a regulator of the expression of the iron absorption-regulating hormone hepicidin/HAMP, plays a role in iron homeostasis".
31	Q9Y5Y6	Suppressor of tumorigenicity 14 protein	855	DOMAIN 214 334 CUB 1 DOMAIN 340 447 CUB 2	Degrades extracellular matrix. Proposed to play a role in breast cancer invasion and metastasis. Exhibits trypsin-like activity as defined by cleavage of synthetic substrates with Arg or Lys as the P1 site. Involved in the terminal differentiation of keratinocytes through prostasin (PRSS8) activation and filaggrin (FLG) processing.

The 31 function of CUB of the protein