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The 113 function of Cadherin of the protein

S.NOUniprot IDProtein Name Sequence LengthCadherin Repeated RegionFunction
1 Q96TA0 Putative protocadherin beta-18 734Potential calcium-dependent cell-adhesion protein.
2 P22223 Cadherin-3 829Cadherins are calcium-dependent cell adhesion proteins.
They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
3 Q08554 Desmocollin-1 894Component of intercellular desmosome junctions.
Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.
Linked to the keratinization of epithelial tissues.
4 Q14574 Desmocollin-3 896Component of intercellular desmosome junctions.
Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.
5 Q02487 Desmocollin-2 901Component of intercellular desmosome junctions.
Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
May contribute to epidermal cell positioning (stratification) by mediating differential adhesiveness between cells that express different isoforms.
6 P55290 Cadherin-13 713Cadherins are calcium-dependent cell adhesion proteins.
They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
May act as a negative regulator of neural cell growth.
7 P12830 Cadherin-1 882"Cadherins are calcium-dependent cell adhesion proteins (PubMed:11976333).
They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
CDH1 is involved in mechanisms regulating cell-cell adhesions, mobility and proliferation of epithelial cells (PubMed:11976333).
Has a potent invasive suppressor role.
It is a ligand for integrin alpha-E/beta-7.
; E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors.
Has a strong inhibitory effect on APP C99 and C83 production".
8 P19022 Cadherin-2 906"Cadherins are calcium-dependent cell adhesion proteins.
They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
Acts as a regulator of neural stem cells quiescence by mediating anchorage of neural stem cells to ependymocytes in the adult subependymal zone: upon cleavage by MMP24, CDH2-mediated anchorage is affected, leading to modulate neural stem cell quiescence.
CDH2 may be involved in neuronal recognition mechanism.
In hippocampal neurons, may regulate dendritic spine density (By similarity)".
9 P55283 Cadherin-4 916Cadherins are calcium-dependent cell adhesion proteins.
They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
May play an important role in retinal development.
10 O14917 Protocadherin-17 1159Potential calcium-dependent cell-adhesion protein.
11 Q9HCU4 Cadherin EGF LAG seven-pass G-type receptor 2 2923Receptor that may have an important role in cell/cell signaling during nervous system formation.
12 Q9P2E7 Protocadherin-101040Potential calcium-dependent cell-adhesion protein.
13 Q9H158 Protocadherin alpha-C1 963Potential calcium-dependent cell-adhesion protein.
May be involved in the establishment and maintenance of specific neuronal connections in the brain.
14 Q8TAB3 Protocadherin-191148Potential calcium-dependent cell-adhesion protein.
15 Q6ZTQ4 Cadherin-related family member 3 885Cadherins are calcium-dependent cell adhesion proteins.
They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
; (Microbial infection) Acts as a receptor for rhinovirus C.
16 A6H8M9 Cadherin-related family member 4 788Cadherins are calcium-dependent cell adhesion proteins.
They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types (By similarity).
17 Q9NYQ6 Cadherin EGF LAG seven-pass G-type receptor 1 3014Receptor that may have an important role in cell/cell signaling during nervous system formation.
18 O75309 Cadherin-16 829Cadherins are calcium-dependent cell adhesion proteins.
They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
19 Q9BZA7 Protocadherin-11 X-linked 1347Potential calcium-dependent cell-adhesion protein.
20 Q9HC56 Protocadherin-91237Potential calcium-dependent cell-adhesion protein.
21 Q9BYE9 Cadherin-related family member 2 1310"Intermicrovillar adhesion molecule that forms, via its extracellular domain, calcium-dependent heterophilic complexes with CDHR5 on adjacent microvilli.
Thereby, controls the packing of microvilli at the apical membrane of epithelial cells.
Through its cytoplasmic domain, interacts with microvillus cytoplasmic proteins to form the intermicrovillar adhesion complex/IMAC.
This complex plays a central role in microvilli and epithelial brush border differentiation (PubMed:24725409).
May also play a role in cell-cell adhesion and contact inhibition in epithelial cells (PubMed:12117771)".
22 Q9NPG4 Protocadherin-12 1184"Cellular adhesion molecule that may play an important role in cell-cell interactions at interendothelial junctions (By similarity).
Acts as a regulator of cell migration, probably via increasing cell-cell adhesion (PubMed:21402705).
Promotes homotypic calcium-dependent aggregation and adhesion and clusters at intercellular junctions (By similarity).
Unable to bind to catenins, weakly associates with the cytoskeleton (By similarity)".
23 Q9HCL0 Protocadherin-181135Potential calcium-dependent cell-adhesion protein.
24 Q9Y5G3 Protocadherin gamma-B1 927Potential calcium-dependent cell-adhesion protein.
May be involved in the establishment and maintenance of specific neuronal connections in the brain.
25 Q9Y5I2 Protocadherin alpha-10 948Potential calcium-dependent cell-adhesion protein.
May be involved in the establishment and maintenance of specific neuronal connections in the brain.
26 Q9Y5H4 Protocadherin gamma-A1 931Potential calcium-dependent cell-adhesion protein.
May be involved in the establishment and maintenance of specific neuronal connections in the brain.
27 Q9Y5G6 Protocadherin gamma-A7 932Potential calcium-dependent cell-adhesion protein.
May be involved in the establishment and maintenance of specific neuronal connections in the brain.
28 Q9Y5G4 Protocadherin gamma-A9 932Potential calcium-dependent cell-adhesion protein.
May be involved in the establishment and maintenance of specific neuronal connections in the brain.
29 Q9Y5H1 Protocadherin gamma-A2 932Potential calcium-dependent cell-adhesion protein.
May be involved in the establishment and maintenance of specific neuronal connections in the brain.
30 Q9BQT9 Calsyntenin-3 956"May modulate calcium-mediated postsynaptic signals.
Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation".
31 Q12864 Cadherin-17 832Cadherins are calcium-dependent cell adhesion proteins.
They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
LI-cadherin may have a role in the morphological organization of liver and intestine.
Involved in intestinal peptide transport.
32 Q9Y5G8 Protocadherin gamma-A5 931Potential calcium-dependent cell-adhesion protein.
May be involved in the establishment and maintenance of specific neuronal connections in the brain.
33 Q9Y5G7 Protocadherin gamma-A6 932Potential calcium-dependent cell-adhesion protein.
May be involved in the establishment and maintenance of specific neuronal connections in the brain.
34 O60330 Protocadherin gamma-A12 932Potential calcium-dependent cell-adhesion protein.
May be involved in the establishment and maintenance of specific neuronal connections in the brain.
35 Q9Y5G5 Protocadherin gamma-A8 932Potential calcium-dependent cell-adhesion protein.
May be involved in the establishment and maintenance of specific neuronal connections in the brain.
36 Q9Y5H0 Protocadherin gamma-A3 932Potential calcium-dependent cell-adhesion protein.
May be involved in the establishment and maintenance of specific neuronal connections in the brain.
37 Q9Y5F6 Protocadherin gamma-C5 944Potential calcium-dependent cell-adhesion protein.
May be involved in the establishment and maintenance of specific neuronal connections in the brain.
38 Q9UN72 Protocadherin alpha-7 937"Calcium-dependent cell-adhesion protein involved in cells self-recognition and non-self discrimination.
Thereby, it is involved in the establishment and maintenance of specific neuronal connections in the brain".
39 Q9Y5F7 Protocadherin gamma-C4 938Potential calcium-dependent cell-adhesion protein.
May be involved in the establishment and maintenance of specific neuronal connections in the brain.
40 Q9UN75 Protocadherin alpha-12 941Potential calcium-dependent cell-adhesion protein.
May be involved in the establishment and maintenance of specific neuronal connections in the brain.
41 Q9UN74 Protocadherin alpha-4 947"Calcium-dependent cell-adhesion protein involved in cells self-recognition and non-self discrimination.
Thereby, it is involved in the establishment and maintenance of specific neuronal connections in the brain".
42 Q9Y5H8 Protocadherin alpha-3 950Potential calcium-dependent cell-adhesion protein.
May be involved in the establishment and maintenance of specific neuronal connections in the brain.
43 Q9Y5H5 Protocadherin alpha-9 950Potential calcium-dependent cell-adhesion protein.
May be involved in the establishment and maintenance of specific neuronal connections in the brain.
44 Q9Y5I1 Protocadherin alpha-11 949Potential calcium-dependent cell-adhesion protein.
May be involved in the establishment and maintenance of specific neuronal connections in the brain.
45 Q9Y5H9 Protocadherin alpha-2 948Potential calcium-dependent cell-adhesion protein.
May be involved in the establishment and maintenance of specific neuronal connections in the brain.
46 Q9Y5H6 Protocadherin alpha-8 950Potential calcium-dependent cell-adhesion protein.
May be involved in the establishment and maintenance of specific neuronal connections in the brain.
47 Q9Y5I3 Protocadherin alpha-1 950Potential calcium-dependent cell-adhesion protein.
May be involved in the establishment and maintenance of specific neuronal connections in the brain.
48 Q9Y5H2 Protocadherin gamma-A11 935Potential calcium-dependent cell-adhesion protein.
May be involved in the establishment and maintenance of specific neuronal connections in the brain.
49 O95206 Protocadherin-8 1070"Calcium-dependent cell-adhesion protein (By similarity).
May play a role in activity-induced synaptic reorganization underlying long term memory (By similarity).
Could be involved in CDH2 internalization through TAOK2/p38 MAPK pathway.
In hippocampal neurons, may play a role in the down-regulation of dendritic spines, maybe through its action on CDH2 endocytosis (By similarity)".
50 Q9Y5G0 Protocadherin gamma-B5 923Potential calcium-dependent cell-adhesion protein.
May be involved in the establishment and maintenance of specific neuronal connections in the brain.
51 Q9UN71 Protocadherin gamma-B4 923Potential calcium-dependent cell-adhesion protein.
May be involved in the establishment and maintenance of specific neuronal connections in the brain.
52 Q9Y5F8 Protocadherin gamma-B7 929Potential calcium-dependent cell-adhesion protein.
May be involved in the establishment and maintenance of specific neuronal connections in the brain.
53 Q9Y5G1 Protocadherin gamma-B3 929Potential calcium-dependent cell-adhesion protein.
May be involved in the establishment and maintenance of specific neuronal connections in the brain.
54 Q9Y5F9 Protocadherin gamma-B6 930Potential calcium-dependent cell-adhesion protein.
May be involved in the establishment and maintenance of specific neuronal connections in the brain.
55 Q9Y5G2 Protocadherin gamma-B2 931Potential calcium-dependent cell-adhesion protein.
May be involved in the establishment and maintenance of specific neuronal connections in the brain.
56 Q9UN70 Protocadherin gamma-C3 934Potential calcium-dependent cell-adhesion protein.
May be involved in the establishment and maintenance of specific neuronal connections in the brain.
57 Q9NYQ7 Cadherin EGF LAG seven-pass G-type receptor 3 3312Receptor that may have an important role in cell/cell signaling during nervous system formation.
58 Q9Y5H7 Protocadherin alpha-5 936Potential calcium-dependent cell-adhesion protein.
May be involved in the establishment and maintenance of specific neuronal connections in the brain.
59 Q9Y5H3 Protocadherin gamma-A10 936Potential calcium-dependent cell-adhesion protein.
May be involved in the establishment and maintenance of specific neuronal connections in the brain.
60 Q9H251 Cadherin-23 3354"Cadherins are calcium-dependent cell adhesion proteins.
They preferentially interact with themselves in a homophilic manner in connecting cells.
CDH23 is required for establishing and/or maintaining the proper organization of the stereocilia bundle of hair cells in the cochlea and the vestibule during late embryonic/early postnatal development.
It is part of the functional network formed by USH1C, USH1G, CDH23 and MYO7A that mediates mechanotransduction in cochlear hair cells.
Required for normal hearing".
61 Q9Y5E3 Protocadherin beta-6 794"Calcium-dependent cell-adhesion protein involved in cells self-recognition and non-self discrimination.
Thereby, it is involved in the establishment and maintenance of specific neuronal connections in the brain".
62 Q9Y5E5 Protocadherin beta-4 795Potential calcium-dependent cell-adhesion protein.
May be involved in the establishment and maintenance of specific neuronal connections in the brain.
63 Q9Y5I0 Protocadherin alpha-13 950Potential calcium-dependent cell-adhesion protein.
May be involved in the establishment and maintenance of specific neuronal connections in the brain.
64 Q9UN73 Protocadherin alpha-6 950Potential calcium-dependent cell-adhesion protein.
May be involved in the establishment and maintenance of specific neuronal connections in the brain.
65 Q9NYQ8 Protocadherin Fat 2 4349Plays a role in the migration of epidermal cells.
May modulate the extracellular space surronding parallel fibers of cerebellar during development (By similarity).
66 Q9Y5F3 Protocadherin beta-1 818Potential calcium-dependent cell-adhesion protein.
May be involved in the establishment and maintenance of specific neuronal connections in the brain.
67 Q9Y5E4 Protocadherin beta-5 795Potential calcium-dependent cell-adhesion protein.
May be involved in the establishment and maintenance of specific neuronal connections in the brain.
68 Q9NRJ7 Protocadherin beta-16 776Potential calcium-dependent cell-adhesion protein.
May be involved in the establishment and maintenance of specific neuronal connections in the brain.
69 Q9Y5E8 Protocadherin beta-15 787Potential calcium-dependent cell-adhesion protein.
May be involved in the establishment and maintenance of specific neuronal connections in the brain.
70 Q9Y5E2 Protocadherin beta-7 793Potential calcium-dependent cell-adhesion protein.
May be involved in the establishment and maintenance of specific neuronal connections in the brain.
71 Q9Y5F1 Protocadherin beta-12 795Potential calcium-dependent cell-adhesion protein.
May be involved in the establishment and maintenance of specific neuronal connections in the brain.
72 Q9Y5E6 Protocadherin beta-3 796Potential calcium-dependent cell-adhesion protein.
May be involved in the establishment and maintenance of specific neuronal connections in the brain.
73 Q9Y5E1 Protocadherin beta-9 797Potential calcium-dependent cell-adhesion protein.
May be involved in the establishment and maintenance of specific neuronal connections in the brain.
74 Q9Y5F2 Protocadherin beta-11 797Potential calcium-dependent cell-adhesion protein.
May be involved in the establishment and maintenance of specific neuronal connections in the brain.
75 Q9Y5E9 Protocadherin beta-14 798Potential calcium-dependent cell-adhesion protein.
May be involved in the establishment and maintenance of specific neuronal connections in the brain.
76 Q9UN67 Protocadherin beta-10 800Potential calcium-dependent cell-adhesion protein.
May be involved in the establishment and maintenance of specific neuronal connections in the brain.
77 Q14517 Protocadherin Fat 1 4588"Plays an essential role for cellular polarization, directed cell migration and modulating cell-cell contact".
78 Q8IXH8 Cadherin-like protein 26 852Cadherins are calcium-dependent cell adhesion proteins.
They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
79 Q9Y5F0 Protocadherin beta-13 798Potential calcium-dependent cell-adhesion protein.
May be involved in the establishment and maintenance of specific neuronal connections in the brain.
80 Q9UN66 Protocadherin beta-8 801"Calcium-dependent cell-adhesion protein involved in cells self-recognition and non-self discrimination.
Thereby, it is involved in the establishment and maintenance of specific neuronal connections in the brain".
81 Q96JP9 Cadherin-related family member 1 859Potential calcium-dependent cell-adhesion protein.
May be required for the structural integrity of the outer segment (OS) of photoreceptor cells (By similarity).
82 Q9Y5E7 Protocadherin beta-2 798Potential calcium-dependent cell-adhesion protein.
May be involved in the establishment and maintenance of specific neuronal connections in the brain.
83 O94985 Calsyntenin-1 981"Induces KLC1 association with vesicles and functions as a cargo in axonal anterograde transport.
Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation.
In complex with APBA2 and C99, a C-terminal APP fragment, abolishes C99 interaction with PSEN1 and thus APP C99 cleavage by gamma-secretase, most probably through stabilization of the direct interaction between APBA2 and APP.
The intracellular fragment AlcICD suppresses APBB1-dependent transactivation stimulated by APP C-terminal intracellular fragment (AICD), most probably by competing with AICD for APBB1-binding.
May modulate calcium-mediated postsynaptic signals (By similarity)".
84 Q96QU1 Protocadherin-151955Calcium-dependent cell-adhesion protein.
Essential for maintenance of normal retinal and cochlear function.
85 Q6V0I7 Protocadherin Fat 4 4981Cadherins are calcium-dependent cell adhesion proteins.
FAT4 plays a role in the maintenance of planar cell polarity as well as in inhibition of YAP1-mediated neuroprogenitor cell proliferation and differentiation (By similarity).
86 Q96JQ0 Protocadherin-16 3298"Calcium-dependent cell-adhesion protein.
Mediates functions in neuroprogenitor cell proliferation and differentiation.
In the heart, has a critical role for proper morphogenesis of the mitral valve, acting in the regulation of cell migration involved in valve formation (PubMed:26258302)".
87 Q9Y5I4 Protocadherin alpha-C2 1007Potential calcium-dependent cell-adhesion protein.
May be involved in the establishment and maintenance of specific neuronal connections in the brain.
88 Q9H159 Cadherin-19772Cadherins are calcium-dependent cell adhesion proteins.
They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
89 Q8TDW7 Protocadherin Fat 3 4589May play a role in the interactions between neurites derived from specific subsets of neurons during development.
90 Q9H4D0 Calsyntenin-2 955May modulate calcium-mediated postsynaptic signals.
91 Q86UP0 Cadherin-24819Cadherins are calcium-dependent cell adhesion proteins.
They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
Cadherin-24 mediate strong cell-cell adhesion.
92 P33151 Cadherin-5 784"Cadherins are calcium-dependent cell adhesion proteins.
They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
This cadherin may play a important role in endothelial cell biology through control of the cohesion and organization of the intercellular junctions.
It associates with alpha-catenin forming a link to the cytoskeleton.
Acts in concert with KRIT1 to establish and maintain correct endothelial cell polarity and vascular lumen.
These effects are mediated by recruitment and activation of the Par polarity complex and RAP1B.
Required for activation of PRKCZ and for the localization of phosphorylated PRKCZ, PARD3, TIAM1 and RAP1B to the cell junction".
93 Q9ULB5 Cadherin-7785Cadherins are calcium-dependent cell adhesion proteins.
They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
94 Q86SJ6 Desmoglein-4 1040Component of intercellular desmosome junctions.
Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes (By similarity).
95 P32926 Desmoglein-3 999Component of intercellular desmosome junctions.
Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
96 Q02413 Desmoglein-1 1049Component of intercellular desmosome junctions.
Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
97 Q14126 Desmoglein-2 1118Component of intercellular desmosome junctions.
Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.
98 Q9ULB4 Cadherin-9789Cadherins are calcium-dependent cell adhesion proteins.
They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
99 P55285 Cadherin-6 790Cadherins are calcium-dependent cell adhesion proteins.
They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
100 Q13634 Cadherin-18 790Cadherins are calcium-dependent cell adhesion proteins.
They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
101 P55287 Cadherin-11 796Cadherins are calcium-dependent cell adhesion proteins.
They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
102 Q9Y6N8 Cadherin-10 788Cadherins are calcium-dependent cell adhesion proteins.
They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
103 P55289 Cadherin-12 794Cadherins are calcium-dependent cell adhesion proteins.
They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
104 Q6V1P9 Protocadherin-23 2916Calcium-dependent cell-adhesion protein.
105 Q08174 Protocadherin-1 1060May be involved in cell-cell interaction processes and in cell adhesion.
106 Q9BZA8 Protocadherin-11 Y-linked 1340Potential calcium-dependent cell-adhesion protein.
107 Q9Y5G9 Protocadherin gamma-A4 962Potential calcium-dependent cell-adhesion protein.
May be involved in the establishment and maintenance of specific neuronal connections in the brain.
108 P55291 Cadherin-15 814Cadherins are calcium-dependent cell adhesion proteins.
They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
M-cadherin is part of the myogenic program and may provide a trigger for terminal muscle differentiation.
109 Q9HBT6 Cadherin-20801Cadherins are calcium-dependent cell adhesion proteins.
They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
110 P55286 Cadherin-8799Cadherins are calcium-dependent cell adhesion proteins.
They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
111 Q9UJ99 Cadherin-22 828Cadherins are calcium-dependent cell adhesion proteins.
They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types.
PB-cadherins may have a role in the morphological organization of pituitary gland and brain tissues (By similarity).
112 Q8N6Y1 Protocadherin-20 951Potential calcium-dependent cell-adhesion protein.
113 Q9HBB8 Cadherin-related family member 5 845"Intermicrovillar adhesion molecule that forms, via its extracellular domain, calcium-dependent heterophilic complexes with CDHR2 on adjacent microvilli.
Thereby, controls the packing of microvilli at the apical membrane of epithelial cells.
Through its cytoplasmic domain, interacts with microvillus cytoplasmic proteins to form the intermicrovillar adhesion complex/IMAC.
This complex plays a central role in microvilli and epithelial brush border differentiation".