BACK HOME

The 5 function of FF of the protein

S.NO	Uniprot ID	Protein Name	Sequence Length	FF Repeated Region	Function
1	O14776	Transcription elongation regulator 1	1098	DOMAIN 659 712 FF 1 DOMAIN 725 779 FF 2 DOMAIN 791 846 FF 3 DOMAIN 896 952 FF 4 DOMAIN 954 1010 FF 5 DOMAIN 1012 1077 FF 6	Transcription factor that binds RNA polymerase II and inhibits the elongation of transcripts from target promoters. Regulates transcription elongation in a TATA box-dependent manner. Necessary for TAT-dependent activation of the human immunodeficiency virus type 1 (HIV-1) promoter.
2	O75400	Pre-mRNA-processing factor 40 homolog A	957	DOMAIN 393 447 FF 1 DOMAIN 460 514 FF 2 DOMAIN 527 587 FF 3 DOMAIN 607 667 FF 4 DOMAIN 672 727 FF 5 DOMAIN 742 799 FF 6	"Binds to WASL/N-WASP and suppresses its translocation from the nucleus to the cytoplasm, thereby inhibiting its cytoplasmic function (By similarity). Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape and migration. May play a role in cytokinesis. May be involved in pre-mRNA splicing".
3	Q13017	Rho GTPase-activating protein 5	1502	DOMAIN 267 325 FF 1 DOMAIN 366 420 FF 2 DOMAIN 427 481 FF 3 DOMAIN 482 548 FF 4	GTPase-activating protein for Rho family members (PubMed:8537347).
4	Q9NRY4	Rho GTPase-activating protein 35	1499	DOMAIN 270 327 FF 1 DOMAIN 368 422 FF 2 DOMAIN 429 483 FF 3 DOMAIN 485 550 FF 4	"Rho GTPase-activating protein (GAP) (PubMed:19673492, PubMed:28894085). Binds several acidic phospholipids which inhibits the Rho GAP activity to promote the Rac GAP activity (PubMed:19673492). This binding is inhibited by phosphorylation by PRKCA (PubMed:19673492). Involved in cell differentiation as well as cell adhesion and migration, plays an important role in retinal tissue morphogenesis, neural tube fusion, midline fusion of the cerebral hemispheres and mammary gland branching morphogenesis (By similarity). Transduces signals from p21-ras to the nucleus, acting via the ras GTPase-activating protein (GAP) (By similarity). Transduces SRC-dependent signals from cell-surface adhesion molecules, such as laminin, to promote neurite outgrowth. Regulates axon outgrowth, guidance and fasciculation (By similarity). Modulates Rho GTPase-dependent F-actin polymerization, organization and assembly, is involved in polarized cell migration and in the positive regulation of ciliogenesis and cilia elongation (By similarity). During mammary gland development, is required in both the epithelial and stromal compartments for ductal outgrowth (By similarity). Represses transcription of the glucocorticoid receptor by binding to the cis-acting regulatory sequence 5'-GAGAAAAGAAACTGGAGAAACTC-3'; this function is however unclear and would need additional experimental evidences (PubMed:1894621)".
5	Q6NWY9	Pre-mRNA-processing factor 40 homolog B	871	DOMAIN 276 330 FF 1 DOMAIN 340 397 FF 2 DOMAIN 410 470 FF 3 DOMAIN 490 550 FF 4 DOMAIN 554 610 FF 5 DOMAIN 625 682 FF 6	May be involved in pre-mRNA splicing.