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The 11 function of IPT/TIG of the protein

S.NOUniprot IDProtein Name Sequence LengthIPT/TIG Repeated RegionFunction
1 O15031 Plexin-B2 1838"Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling.
Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248'.
Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development.
Regulates the migration of cerebellar granule cells in the developing brain.
Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton.
Plays a role in axon guidance, invasive growth and cell migration.
May modulate the activity of RAC1 and CDC42.
Down-regulates macrophage migration in wound-healing assays (in vitro) (By similarity)".
2 O43157 Plexin-B1 2135"Receptor for SEMA4D.
Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton.
Plays a role in axon guidance, invasive growth and cell migration".
3 P51805 Plexin-A3 1871"Coreceptor for SEMA3A and SEMA3F.
Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton.
Plays a role in axon guidance in the developing nervous system.
Regulates the migration of sympathetic neurons, but not of neural crest precursors.
Required for normal dendrite spine morphology in pyramidal neurons.
May play a role in regulating semaphorin-mediated programmed cell death in the developing nervous system.
Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin.
The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm".
4 P08F94 Fibrocystin 4074May be required for correct bipolar cell division through the regulation of centrosome duplication and mitotic spindle assembly.
May be a receptor protein that acts in collecting-duct and biliary differentiation.
5 Q9HCM2 Plexin-A41894"Coreceptor for SEMA3A.
Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton.
Plays a role in axon guidance in the developing nervous system.
Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin.
The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity)".
6 Q9UIW2 Plexin-A1 1896"Coreceptor for SEMA3A, SEMA3C, SEMA3F and SEMA6D.
Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton.
Plays a role in axon guidance, invasive growth and cell migration.
Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin.
The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity)".
7 P08581 Hepatocyte growth factor receptor 1390"Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to hepatocyte growth factor/HGF ligand.
Regulates many physiological processes including proliferation, scattering, morphogenesis and survival.
Ligand binding at the cell surface induces autophosphorylation of MET on its intracellular domain that provides docking sites for downstream signaling molecules.
Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1, SRC, GRB2, STAT3 or the adapter GAB1.
Recruitment of these downstream effectors by MET leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC.
The RAS-ERK activation is associated with the morphogenetic effects while PI3K/AKT coordinates prosurvival effects.
During embryonic development, MET signaling plays a role in gastrulation, development and migration of muscles and neuronal precursors, angiogenesis and kidney formation.
In adults, participates in wound healing as well as organ regeneration and tissue remodeling.
Promotes also differentiation and proliferation of hematopoietic cells.
May regulate cortical bone osteogenesis (By similarity).
; Acts as a receptor for Listeria internalin inlB, mediating entry of the pathogen into cells".
8 Q04912 Macrophage-stimulating protein receptor 1400"Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand.
Regulates many physiological processes including cell survival, migration and differentiation.
Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules.
Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1.
Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC.
RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site.
Plays also a role in the innate immune response by regulating the migration and phagocytic activity of macrophages.
Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand".
9 O75051 Plexin-A2 1894"Coreceptor for SEMA3A and SEMA6A.
Necessary for signaling by SEMA6A and class 3 semaphorins and subsequent remodeling of the cytoskeleton.
Plays a role in axon guidance, invasive growth and cell migration.
Class 3 semaphorins bind to a complex composed of a neuropilin and a plexin.
The plexin modulates the affinity of the complex for specific semaphorins, and its cytoplasmic domain is required for the activation of down-stream signaling events in the cytoplasm (By similarity)".
10 Q9ULL4 Plexin-B31909"Receptor for SEMA5A that plays a role in axon guidance, invasive growth and cell migration.
Stimulates neurite outgrowth and mediates Ca(2+)/Mg(2+)-dependent cell aggregation.
In glioma cells, SEMA5A stimulation of PLXNB3 results in the disassembly of F-actin stress fibers, disruption of focal adhesions and cellular collapse as well as inhibition of cell migration and invasion through ARHGDIA-mediated inactivation of RAC1".
11 Q9Y4D7 Plexin-D11925"Cell surface receptor for SEMA4A and for class 3 semaphorins, such as SEMA3A, SEMA3C and SEMA3E.
Plays an important role in cell-cell signaling, and in regulating the migration of a wide spectrum of cell types.
Regulates the migration of thymocytes in the medulla.
Regulates endothelial cell migration.
Plays an important role in ensuring the specificity of synapse formation.
Required for normal development of the heart and vasculature (By similarity).
Mediates anti-angiogenic signaling in response to SEMA3E".