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The 5 function of Kringle of the protein

S.NO	Uniprot ID	Protein Name	Sequence Length	Kringle Repeated Region	Function
1	P08519	Apolipoprotein	4548	DOMAIN 20 130 Kringle 1 DOMAIN 131 244 Kringle 2 DOMAIN 245 358 Kringle 3 DOMAIN 359 472 Kringle 4 DOMAIN 473 586 Kringle 5 DOMAIN 587 700 Kringle 6 DOMAIN 701 814 Kringle 7 DOMAIN 815 928 Kringle 8 DOMAIN 929 1042 Kringle 9 DOMAIN 1043 1156 Kringle 10 DOMAIN 1157 1270 Kringle 11 DOMAIN 1271 1384 Kringle 12 DOMAIN 1385 1498 Kringle 13 DOMAIN 1499 1612 Kringle 14 DOMAIN 1613 1726 Kringle 15 DOMAIN 1727 1840 Kringle 16 DOMAIN 1841 1954 Kringle 17 DOMAIN 1955 2068 Kringle 18 DOMAIN 2069 2182 Kringle 19 DOMAIN 2183 2296 Kringle 20 DOMAIN 2297 2410 Kringle 21 DOMAIN 2411 2524 Kringle 22 DOMAIN 2525 2638 Kringle 23 DOMAIN 2639 2752 Kringle 24 DOMAIN 2753 2866 Kringle 25 DOMAIN 2867 2980 Kringle 26 DOMAIN 2981 3094 Kringle 27 DOMAIN 3095 3208 Kringle 28 DOMAIN 3209 3322 Kringle 29 DOMAIN 3323 3436 Kringle 30 DOMAIN 3437 3550 Kringle 31 DOMAIN 3551 3664 Kringle 32 DOMAIN 3665 3770 Kringle 33 DOMAIN 3771 3884 Kringle 34 DOMAIN 3885 3998 Kringle 35 DOMAIN 3999 4112 Kringle 36 DOMAIN 4113 4226 Kringle 37 DOMAIN 4227 4327 Kringle 38	Apo(a) is the main constituent of lipoprotein(a) (Lp(a)). It has serine proteinase activity and is able of autoproteolysis. Inhibits tissue-type plasminogen activator 1. Lp(a) may be a ligand for megalin/Gp 330.
2	P00747	Plasminogen	810	DOMAIN 103 181 Kringle 1 DOMAIN 184 262 Kringle 2 DOMAIN 275 352 Kringle 3 DOMAIN 377 454 Kringle 4 DOMAIN 481 560 Kringle 5	"Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells. ; Angiostatin is an angiogenesis inhibitor that blocks neovascularization and growth of experimental primary and metastatic tumors in vivo".
3	P14210	Hepatocyte growth factor	728	DOMAIN 128 206 Kringle 1 DOMAIN 211 288 Kringle 2 DOMAIN 305 383 Kringle 3 DOMAIN 391 469 Kringle 4	"Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization".
4	P00750	Tissue-type plasminogen activator	562	DOMAIN 127 208 Kringle 1 DOMAIN 215 296 Kringle 2	"Converts the abundant, but inactive, zymogen plasminogen to plasmin by hydrolyzing a single Arg-Val bond in plasminogen. By controlling plasmin-mediated proteolysis, it plays an important role in tissue remodeling and degradation, in cell migration and many other physiopathological events. Plays a direct role in facilitating neuronal migration".
5	P00734	Prothrombin	622	DOMAIN 108 186 Kringle 1 DOMAIN 213 291 Kringle 2	"Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing".