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The 12 function of SAM of the protein

S.NOUniprot IDProtein Name Sequence LengthSAM Repeated RegionFunction
1 Q8WXD9 Caskin-1 1431May link the scaffolding protein CASK to downstream intracellular effectors.
2 Q6SZW1 Sterile alpha and TIR motif-containing protein 1 724"Negative regulator of MYD88- and TRIF-dependent toll-like receptor signaling pathway which plays a pivotal role in activating axonal degeneration following injury.
Promotes Wallerian degeneration an injury-induced axonal death pathway which involves degeneration of an axon distal to the injury site.
Can activate neuronal death in response to stress.
Regulates dendritic arborization through the MAPK4-JNK pathway.
Involved in innate immune response.
Inhibits both TICAM1/TRIF- and MYD88-dependent activation of JUN/AP-1, TRIF-dependent activation of NF-kappa-B and IRF3, and the phosphorylation of MAPK14/p38".
3 Q674X7 Kazrin775Component of the cornified envelope of keratinocytes.
May be involved in the interplay between adherens junctions and desmosomes.
The function in the nucleus is not known.
4 O94885 SAM and SH3 domain-containing protein 1 1247May have a role in a signaling pathway.
Could act as a tumor suppressor.
5 Q8ND30 Liprin-beta-2 876May regulate the disassembly of focal adhesions.
Did not bind receptor-like tyrosine phosphatases type 2A.
6 Q86W92 Liprin-beta-1 1011May regulate the disassembly of focal adhesions.
Did not bind receptor-like tyrosine phosphatases type 2A.
7 Q92625 Ankyrin repeat and SAM domain-containing protein 1A 1134Regulator of different signaling pathways.
Regulates EPHA8 receptor tyrosine kinase signaling to control cell migration and neurite retraction (By similarity).
8 Q7Z6G8 Ankyrin repeat and sterile alpha motif domain-containing protein 1B 1248Isoform 2 may participate in the regulation of nucleoplasmic coilin protein interactions in neuronal and transformed cells.
; Isoform 3 can regulate global protein synthesis by altering nucleolar numbers.
; Isoform 4 may play a role as a modulator of APP processing.
Overexpression can down-regulate APP processing.
9 O75335 Liprin-alpha-4 1185"May regulate the disassembly of focal adhesions.
May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates (By similarity)".
10 O75145 Liprin-alpha-3 1194"May regulate the disassembly of focal adhesions.
May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates".
11 Q13136 Liprin-alpha-1 1202"May regulate the disassembly of focal adhesions.
May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates".
12 O75334 Liprin-alpha-2 1257"Alters PTPRF cellular localization and induces PTPRF clustering.
May regulate the disassembly of focal adhesions.
May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates".