S.NO | Uniprot ID | Protein Name | Sequence Length | SEC63 Repeated Region | Function |
1 | Q9UGP8 | Translocation protein SEC63 homolog | 760 | Required for integral membrane and secreted preprotein translocation across the endoplasmic reticulum membrane. | |
2 | Q8N3C0 | Activating signal cointegrator 1 complex subunit 3 | 2202 | "3'-5' DNA helicase involved in repair of alkylated DNA. Promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3, enabling ALKBH3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions. Enhances NF-kappa-B, SRF and AP1 transactivation". | |
3 | O75643 | U5 small nuclear ribonucleoprotein 200 kDa helicase | 2136 | "RNA helicase that plays an essential role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes. Involved in spliceosome assembly, activation and disassembly. Mediates changes in the dynamic network of RNA-RNA interactions in the spliceosome. Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome". |