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The 3 function of SEC63 of the protein

S.NOUniprot IDProtein Name Sequence LengthSEC63 Repeated RegionFunction
1 Q9UGP8 Translocation protein SEC63 homolog760Required for integral membrane and secreted preprotein translocation across the endoplasmic reticulum membrane.
2 Q8N3C0 Activating signal cointegrator 1 complex subunit 3 2202"3'-5' DNA helicase involved in repair of alkylated DNA.
Promotes DNA unwinding to generate single-stranded substrate needed for ALKBH3, enabling ALKBH3 to process alkylated N3-methylcytosine (3mC) within double-stranded regions.
Enhances NF-kappa-B, SRF and AP1 transactivation".
3 O75643 U5 small nuclear ribonucleoprotein 200 kDa helicase 2136"RNA helicase that plays an essential role in pre-mRNA splicing as component of the U5 snRNP and U4/U6-U5 tri-snRNP complexes.
Involved in spliceosome assembly, activation and disassembly.
Mediates changes in the dynamic network of RNA-RNA interactions in the spliceosome.
Catalyzes the ATP-dependent unwinding of U4/U6 RNA duplices, an essential step in the assembly of a catalytically active spliceosome".