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The 11 function of VWFD of the protein

S.NOUniprot IDProtein Name Sequence LengthVWFD Repeated RegionFunction
1 Q6ZRI0 Otogelin2925Glycoprotein specific to acellular membranes of the inner ear.
May be required for the anchoring of the otoconial membranes and cupulae to the underlying neuroepithelia in the vestibule.
May be involved in the organization and/or stabilization of the fibrillar network that compose the tectorial membrane in the cochlea.
May play a role in mechanotransduction processes (By similarity).
2 A2VEC9 SCO-spondin5150Involved in the modulation of neuronal aggregation.
May be involved in developmental events during the formation of the central nervous system (By similarity).
3 P04275 von Willebrand factor 2813"Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet-surface receptor complex GPIb-IX-V.
Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma".
4 Q02817 Mucin-2 5179"Coats the epithelia of the intestines, airways, and other mucus membrane-containing organs.
Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces.
Major constituent of both the inner and outer mucus layers of the colon and may play a role in excluding bacteria from the inner mucus layer".
5 Q9Y493 Zonadhesin2812Binds in a species-specific manner to the zona pellucida of the egg.
May be involved in gamete recognition and/or signaling.
6 Q6W4X9 Mucin-6 2439May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen.
Plays an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers.
May play a role in epithelial organogenesis.
7 Q9Y6R7 IgGFc-binding protein 5405May be involved in the maintenance of the mucosal structure as a gel-like component of the mucosa.
8 Q7Z5P9 Mucin-19 8384May function in ocular mucus homeostasis.
9 Q9HC84 Mucin-5B 5762Gel-forming mucin that is thought to contribute to the lubricating and viscoelastic properties of whole saliva and cervical mucus.
10 P98088 Mucin-5AC 5654Gel-forming glycoprotein of gastric and respiratoy tract epithelia that protects the mucosa from infection and chemical damage by binding to inhaled microrganisms and particles that are subsequently removed by the mucocilary system.
11 O75443 Alpha-tectorin2155"One of the major non-collagenous components of the tectorial membrane (By similarity).
The tectorial membrane is an extracellular matrix of the inner ear that covers the neuroepithelium of the cochlea and contacts the stereocilia bundles of specialized sensory hair cells.
Sound induces movement of these hair cells relative to the tectorial membrane, deflects the stereocilia and leads to fluctuations in hair-cell membrane potential, transducing sound into electrical signals".