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The 1 CKB Repeats proteins and their functions

S.NOUniprot ID Protein Name Sequence LengthCKB Repeats regionFunction
1 Q9HAW4 Claspin 1339Required for checkpoint mediated cell cycle arrest in response to inhibition of DNA replication or to DNA damage induced by both ionizing and UV irradiation
Adapter protein which binds to BRCA1 and the checkpoint kinase CHEK1 and facilitates the ATR-dependent phosphorylation of both proteins
Can also bind specifically to branched DNA structures and may associate with S-phase chromatin following formation of the pre-replication complex (pre-RC)
This may indicate a role for this protein as a sensor which monitors the integrity of DNA replication forks