S.NO	Uniprot ID	Protein Name	Sequence Length	FG Repeats region	Function
1	O15504	Nucleoporin-like protein 2	423	REPEAT 14 15 FG 1 REPEAT 95 96 FG 2 REPEAT 218 219 FG 3 REPEAT 220 221 FG 4 REPEAT 265 266 FG 5 REPEAT 271 272 FG 6 REPEAT 288 289 FG 7 REPEAT 290 291 FG 8 REPEAT 311 312 FG 9 REPEAT 336 337 FG 10 REPEAT 345 346 FG 11 REPEAT 364 365 FG 12	"Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm In case of infection by HIV-1, it may participate in the docking of viral Vpr at the nuclear envelope"
2	P11215	Integrin alpha-M	1152	REPEAT 18 75 FG-GAP 1 REPEAT 76 135 FG-GAP 2 REPEAT 339 390 FG-GAP 3 REPEAT 391 442 FG-GAP 4 REPEAT 443 503 FG-GAP 5 REPEAT 506 564 FG-GAP 6 REPEAT 569 629 FG-GAP 7	"Integrin ITGAM/ITGB2 is implicated in various adhesive interactions of monocytes, macrophages and granulocytes as well as in mediating the uptake of complement-coated particles It is identical with CR-3, the receptor for the iC3b fragment of the third complement component It probably recognizes the R-G-D peptide in C3b Integrin ITGAM/ITGB2 is also a receptor for fibrinogen, factor X and ICAM1 It recognizes P1 and P2 peptides of fibrinogen gamma chain Regulates neutrophil migration (PubMed:28807980) In association with beta subunit ITGB2/CD18, required for CD177-PRTN3-mediated activation of TNF primed neutrophils (PubMed:21193407) May regulate phagocytosis-induced apoptosis in extravasated neutrophils (By similarity) May play a role in mast cell development (By similarity)"
3	Q969R8	KICSTOR complex protein ITFG2	447	REPEAT 19 48 FG-GAP 1 REPEAT 126 155 FG-GAP 2	"As part of the KICSTOR complex functions in the amino acid-sensing branch of the TORC1 signaling pathway Recruits, in an amino acid-independent manner, the GATOR1 complex to the lysosomal membranes and allows its interaction with GATOR2 and the RAG GTPases Functions upstream of the RAG GTPases and is required to negatively regulate mTORC1 signaling in absence of amino acids In absence of the KICSTOR complex mTORC1 is constitutively localized to the lysosome and activated The KICSTOR complex is also probably involved in the regulation of mTORC1 by glucose"
4	Q13349	Integrin alpha-D	1161	REPEAT 19 76 FG-GAP 1 REPEAT 77 136 FG-GAP 2 REPEAT 339 390 FG-GAP 3 REPEAT 391 442 FG-GAP 4 REPEAT 443 503 FG-GAP 5 REPEAT 506 564 FG-GAP 6 REPEAT 569 629 FG-GAP 7	"Integrin alpha-D/beta-2 is a receptor for ICAM3 and VCAM1 May play a role in the atherosclerotic process such as clearing lipoproteins from plaques and in phagocytosis of blood-borne pathogens, particulate matter, and senescent erythrocytes from the blood"
5	P38570	Integrin alpha-E	1179	REPEAT 22 79 FG-GAP 1 REPEAT 80 138 FG-GAP 2 REPEAT 390 442 FG-GAP 3 REPEAT 447 499 FG-GAP 4 REPEAT 500 560 FG-GAP 5 REPEAT 563 627 FG-GAP 6 REPEAT 631 691 FG-GAP 7	Integrin alpha-E/beta-7 is a receptor for E-cadherin It mediates adhesion of intra-epithelial T-lymphocytes to epithelial cell monolayers
6	P20702	Integrin alpha-X	1163	REPEAT 23 78 FG-GAP 1 REPEAT 79 138 FG-GAP 2 REPEAT 340 391 FG-GAP 3 REPEAT 392 443 FG-GAP 4 REPEAT 444 504 FG-GAP 5 REPEAT 507 565 FG-GAP 6 REPEAT 570 630 FG-GAP 7	Integrin alpha-X/beta-2 is a receptor for fibrinogen It recognizes the sequence G-P-R in fibrinogen It mediates cell-cell interaction during inflammatory responses It is especially important in monocyte adhesion and chemotaxis
7	Q9UKX5	Integrin alpha-11	1188	REPEAT 24 85 FG-GAP 1 REPEAT 91 151 FG-GAP 2 REPEAT 355 406 FG-GAP 3 REPEAT 411 461 FG-GAP 4 REPEAT 462 527 FG-GAP 5 REPEAT 528 586 FG-GAP 6 REPEAT 590 650 FG-GAP 7	Integrin alpha-11/beta-1 is a receptor for collagen
8	O75578	Integrin alpha-10	1167	REPEAT 24 85 FG-GAP 1 REPEAT 95 154 FG-GAP 2 REPEAT 361 412 FG-GAP 3 REPEAT 417 470 FG-GAP 4 REPEAT 472 534 FG-GAP 5 REPEAT 535 593 FG-GAP 6 REPEAT 597 657 FG-GAP 7	Integrin alpha-10/beta-1 is a receptor for collagen
9	P56199	Integrin alpha-1	1179	REPEAT 30 91 FG-GAP 1 REPEAT 101 160 FG-GAP 2 REPEAT 365 417 FG-GAP 3 REPEAT 422 475 FG-GAP 4 REPEAT 476 538 FG-GAP 5 REPEAT 557 615 FG-GAP 6 REPEAT 619 679 FG-GAP 7	"Integrin alpha-1/beta-1 is a receptor for laminin and collagen It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen Involved in anchorage-dependent, negative regulation of EGF-stimulated cell growth"
10	P23229	Integrin alpha-6	1130	REPEAT 30 95 FG-GAP 1 REPEAT 101 166 FG-GAP 2 REPEAT 176 229 FG-GAP 3 REPEAT 283 339 FG-GAP 4 REPEAT 340 402 FG-GAP 5 REPEAT 403 458 FG-GAP 6 REPEAT 459 518 FG-GAP 7	Integrin alpha-6/beta-1 is a receptor for laminin on platelets Integrin alpha-6/beta-4 is a receptor for laminin in epithelial cells and it plays a critical structural role in the hemidesmosome (By similarity) ITGA6:ITGB4 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778) ITGA6:ITGB4 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:22351760) ITGA6:ITGB4 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464)
11	P20701	Integrin alpha-L	1170	REPEAT 31 82 FG-GAP 1 REPEAT 83 141 FG-GAP 2 REPEAT 338 389 FG-GAP 3 REPEAT 390 445 FG-GAP 4 REPEAT 446 506 FG-GAP 5 REPEAT 507 563 FG-GAP 6 REPEAT 567 627 FG-GAP 7	"Integrin alpha-L/beta-2 is a receptor for ICAM1, ICAM2, ICAM3 and ICAM4 Integrin alpha-L/beta-2 is also a receptor for F11R (PubMed:11812992, PubMed:15528364) Involved in a variety of immune phenomena including leukocyte-endothelial cell interaction, cytotoxic T-cell mediated killing, and antibody dependent killing by granulocytes and monocytes Contributes to natural killer cell cytotoxicity (PubMed:15356110) Involved in leukocyte adhesion and transmigration of leukocytes including T-cells and neutrophils (PubMed:11812992) Required for generation of common lymphoid progenitor cells in bone marrow, indicating a role in lymphopoiesis (By similarity) Integrin alpha-L/beta-2 in association with ICAM3, contributes to apoptotic neutrophil phagocytosis by macrophages (PubMed:23775590)"
12	P06756	Integrin alpha-V	1048	REPEAT 32 98 FG-GAP 1 REPEAT 109 170 FG-GAP 2 REPEAT 173 225 FG-GAP 3 REPEAT 237 291 FG-GAP 4 REPEAT 292 357 FG-GAP 5 REPEAT 358 415 FG-GAP 6 REPEAT 419 482 FG-GAP 7	"The alpha-V (ITGAV) integrins are receptors for vitronectin, cytotactin, fibronectin, fibrinogen, laminin, matrix metalloproteinase-2, osteopontin, osteomodulin, prothrombin, thrombospondin and vWF They recognize the sequence R-G-D in a wide array of ligands ITGAV:ITGB3 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415) ITGAV:ITGB3 binds to NRG1 (via EGF domain) and this binding is essential for NRG1-ERBB signaling (PubMed:20682778) ITGAV:ITGB3 binds to FGF1 and this binding is essential for FGF1 signaling (PubMed:18441324) ITGAV:ITGB3 binds to FGF2 and this binding is essential for FGF2 signaling (PubMed:28302677) ITGAV:ITGB3 binds to IGF1 and this binding is essential for IGF1 signaling (PubMed:19578119) ITGAV:ITGB3 binds to IGF2 and this binding is essential for IGF2 signaling (PubMed:28873464) ITGAV:ITGB3 binds to IL1B and this binding is essential for IL1B signaling (PubMed:29030430) ITGAV:ITGB3 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877) ITGAV:ITGB3 and ITGAV:ITGB6 act as a receptor for fibrillin-1 (FBN1) and mediate R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881) ; (Microbial infection) Integrin ITGAV:ITGB5 acts as a receptor for Adenovirus type C ; (Microbial infection) Integrin ITGAV:ITGB5 and ITGAV:ITGB3 act as receptors for Coxsackievirus A9 and B1 ; (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for Herpes virus 8/HHV-8 ; (Microbial infection) Integrin ITGAV:ITGB6 acts as a receptor for herpes simplex 1/HHV-1 ; (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for Human parechovirus 1 ; (Microbial infection) Integrin ITGAV:ITGB3 acts as a receptor for West nile virus ; (Microbial infection) In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions"
13	P17301	Integrin alpha-2	1181	REPEAT 34 92 FG-GAP 1 REPEAT 101 161 FG-GAP 2 REPEAT 366 420 FG-GAP 3 REPEAT 423 475 FG-GAP 4 REPEAT 477 539 FG-GAP 5 REPEAT 540 598 FG-GAP 6 REPEAT 602 664 FG-GAP 7	"Integrin alpha-2/beta-1 is a receptor for laminin, collagen, collagen C-propeptides, fibronectin and E-cadherin It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen It is responsible for adhesion of platelets and other cells to collagens, modulation of collagen and collagenase gene expression, force generation and organization of newly synthesized extracellular matrix ; (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human rotavirus A ; (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human echoviruses 1 and 8"
14	P13612	Integrin alpha-4	1032	REPEAT 35 100 FG-GAP 1 REPEAT 110 177 FG-GAP 2 REPEAT 185 237 FG-GAP 3 REPEAT 238 291 FG-GAP 4 REPEAT 292 351 FG-GAP 5 REPEAT 355 412 FG-GAP 6 REPEAT 416 478 FG-GAP 7	"Integrins alpha-4/beta-1 (VLA-4) and alpha-4/beta-7 are receptors for fibronectin They recognize one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin They are also receptors for VCAM1 Integrin alpha-4/beta-1 recognizes the sequence Q-I-D-S in VCAM1 Integrin alpha-4/beta-7 is also a receptor for MADCAM1 It recognizes the sequence L-D-T in MADCAM1 On activated endothelial cells integrin VLA-4 triggers homotypic aggregation for most VLA-4-positive leukocyte cell lines It may also participate in cytolytic T-cell interactions with target cells ITGA4:ITGB1 binds to fractalkine (CX3CL1) and may act as its coreceptor in CX3CR1-dependent fractalkine signaling (PubMed:23125415) ITGA4:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877)"
15	Q13683	Integrin alpha-7 [Cleaved into: Integrin alpha-7 heavy chain; Integrin alpha-7 light chain; Integrin alpha-7 70 kDa form]	1181	REPEAT 35 103 FG-GAP 1 REPEAT 110 175 FG-GAP 2 REPEAT 185 238 FG-GAP 3 REPEAT 292 349 FG-GAP 4 REPEAT 350 411 FG-GAP 5 REPEAT 412 467 FG-GAP 6 REPEAT 471 530 FG-GAP 7	"Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro) Acts as Schwann cell receptor for laminin-2 Acts as a receptor of COMP and mediates its effect on vascular smooth muscle cells (VSMCs) maturation (By similarity) Required to promote contractile phenotype acquisition in differentiated airway smooth muscle (ASM) cells"
16	P08514	Integrin alpha-IIb	1039	REPEAT 35 96 FG-GAP 1 REPEAT 110 173 FG-GAP 2 REPEAT 187 238 FG-GAP 3 REPEAT 251 305 FG-GAP 4 REPEAT 306 371 FG-GAP 5 REPEAT 373 432 FG-GAP 6 REPEAT 435 496 FG-GAP 7	"Integrin alpha-IIb/beta-3 is a receptor for fibronectin, fibrinogen, plasminogen, prothrombin, thrombospondin and vitronectin It recognizes the sequence R-G-D in a wide array of ligands It recognizes the sequence H-H-L-G-G-G-A-K-Q-A-G-D-V in fibrinogen gamma chain Following activation integrin alpha-IIb/beta-3 brings about platelet/platelet interaction through binding of soluble fibrinogen This step leads to rapid platelet aggregation which physically plugs ruptured endothelial cell surface"
17	Q13797	Integrin alpha-9	1035	REPEAT 35 96 FG-GAP 1 REPEAT 111 174 FG-GAP 2 REPEAT 182 232 FG-GAP 3 REPEAT 233 289 FG-GAP 4 REPEAT 290 349 FG-GAP 5 REPEAT 351 408 FG-GAP 6 REPEAT 411 474 FG-GAP 7	"Integrin alpha-9/beta-1 (ITGA9:ITGB1) is a receptor for VCAM1, cytotactin and osteopontin It recognizes the sequence A-E-I-D-G-I-E-L in cytotactin"
18	P80108	Phosphatidylinositol-glycan-specific phospholipase D	840	REPEAT 367 428 FG-GAP 1 REPEAT 436 497 FG-GAP 2 REPEAT 499 559 FG-GAP 3 REPEAT 563 623 FG-GAP 4 REPEAT 633 693 FG-GAP 5 REPEAT 704 770 FG-GAP 6 REPEAT 788 840 FG-GAP 7	This protein hydrolyzes the inositol phosphate linkage in proteins anchored by phosphatidylinositol glycans (GPI-anchor) thus releasing these proteins from the membrane
19	P26006	Integrin alpha-3	1051	REPEAT 38 103 FG-GAP 1 REPEAT 110 171 FG-GAP 2 REPEAT 185 235 FG-GAP 3 REPEAT 236 292 FG-GAP 4 REPEAT 293 354 FG-GAP 5 REPEAT 356 411 FG-GAP 6 REPEAT 415 477 FG-GAP 7	"Integrin alpha-3/beta-1 is a receptor for fibronectin, laminin, collagen, epiligrin, thrombospondin and CSPG4 Integrin alpha-3/beta-1 provides a docking site for FAP (seprase) at invadopodia plasma membranes in a collagen-dependent manner and hence may participate in the adhesion, formation of invadopodia and matrix degradation processes, promoting cell invasion Alpha-3/beta-1 may mediate with LGALS3 the stimulation by CSPG4 of endothelial cells migration"
20	P08648	Integrin alpha-5	1049	REPEAT 43 108 FG-GAP 1 REPEAT 128 188 FG-GAP 2 REPEAT 192 245 FG-GAP 3 REPEAT 259 311 FG-GAP 4 REPEAT 312 377 FG-GAP 5 REPEAT 378 437 FG-GAP 6 REPEAT 441 504 FG-GAP 7	"Integrin alpha-5/beta-1 (ITGA5:ITGB1) is a receptor for fibronectin and fibrinogen It recognizes the sequence R-G-D in its ligands ITGA5:ITGB1 binds to PLA2G2A via a site (site 2) which is distinct from the classical ligand-binding site (site 1) and this induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:18635536, PubMed:25398877) ITGA5:ITGB1 acts as a receptor for fibrillin-1 (FBN1) and mediates R-G-D-dependent cell adhesion to FBN1 (PubMed:12807887, PubMed:17158881) ITGA5:ITGB1 is a receptor for IL1B and binding is essential for IL1B signaling (PubMed:29030430) ; (Microbial infection) Integrin ITGA5:ITGB1 acts as a receptor for Human metapneumovirus ; (Microbial infection) Integrin ITGA2:ITGB1 acts as a receptor for Human parvovirus B19 ; (Microbial infection) In case of HIV-1 infection, the interaction with extracellular viral Tat protein seems to enhance angiogenesis in Kaposi's sarcoma lesions"
21	P53708	Integrin alpha-8 [Cleaved into: Integrin alpha-8 heavy chain; Integrin alpha-8 light chain]	1063	REPEAT 44 105 FG-GAP 1 REPEAT 122 183 FG-GAP 2 REPEAT 188 240 FG-GAP 3 REPEAT 253 306 FG-GAP 4 REPEAT 307 372 FG-GAP 5 REPEAT 373 431 FG-GAP 6 REPEAT 435 498 FG-GAP 7	"Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN NPNT is probably its functional ligand in kidney genesis Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons"
22	Q8TB96	T-cell immunomodulatory protein	612	REPEAT 258 293 FG-GAP	Modulator of T-cell function Has a protective effect in graft versus host disease model (By similarity)

The 1 FG Repeats proteins and their functions