| S.NO | Uniprot ID | Protein Name | Sequence Length | LNR Repeats region | Function |
| 1 | Q99466 | Neurogenic locus notch homolog protein 4 | 2003 | "Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus Affects the implementation of differentiation, proliferation and apoptotic programs May regulate branching morphogenesis in the developing vascular system (By similarity)" | |
| 2 | Q9UM47 | Neurogenic locus notch homolog protein 3 | 2321 | "Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination (PubMed:15350543) Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity)" | |
| 3 | Q04721 | Neurogenic locus notch homolog protein 2 | 2471 | "Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus Affects the implementation of differentiation, proliferation and apoptotic programs (By similarity) Involved in bone remodeling and homeostasis In collaboration with RELA/p65 enhances NFATc1 promoter activity and positively regulates RANKL-induced osteoclast differentiation (PubMed:29149593) Positively regulates self-renewal of liver cancer cells (PubMed:25985737)" | |
| 4 | P46531 | Neurogenic locus notch homolog protein 1 | 2555 | "Functions as a receptor for membrane-bound ligands Jagged1, Jagged2 and Delta1 to regulate cell-fate determination Upon ligand activation through the released notch intracellular domain (NICD) it forms a transcriptional activator complex with RBPJ/RBPSUH and activates genes of the enhancer of split locus Affects the implementation of differentiation, proliferation and apoptotic programs Involved in angiogenesis; negatively regulates endothelial cell proliferation and migration and angiogenic sprouting Involved in the maturation of both CD4+ and CD8+ cells in the thymus Important for follicular differentiation and possibly cell fate selection within the follicle During cerebellar development, functions as a receptor for neuronal DNER and is involved in the differentiation of Bergmann glia Represses neuronal and myogenic differentiation May play an essential role in postimplantation development, probably in some aspect of cell specification and/or differentiation May be involved in mesoderm development, somite formation and neurogenesis May enhance HIF1A function by sequestering HIF1AN away from HIF1A Required for the THBS4 function in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury Involved in determination of left/right symmetry by modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO)" | |
| 5 | Q3T906 | N-acetylglucosamine-1-phosphotransferase subunits alpha/beta | 1256 | "Catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus M6P residues are required to bind to the M6P receptors (MPR), which mediate the vesicular transport of lysosomal enzymes to the endosomal/prelysosomal compartment" |