BACK HOME

The 4 PFTB Repeats proteins and their functions

S.NO	Uniprot ID	Protein Name	Sequence Length	PFTB Repeats region	Function
1	P49356	Protein farnesyltransferase subunit beta	437	REPEAT 123 164 PFTB 1 REPEAT 174 215 PFTB 2 REPEAT 222 263 PFTB 3 REPEAT 270 312 PFTB 4 REPEAT 332 374 PFTB 5	Essential subunit of the farnesyltransferase complex Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X
2	P48449	Lanosterol synthase	732	REPEAT 124 165 PFTB 1 REPEAT 483 528 PFTB 2 REPEAT 560 600 PFTB 3 REPEAT 612 653 PFTB 4	"Catalyzes the cyclization of (S)-2,3 oxidosqualene to lanosterol, a reaction that forms the sterol nucleus Through the production of lanosterol may regulate lens protein aggregation and increase transparency"
3	P53609	Geranylgeranyl transferase type-1 subunit beta	377	REPEAT 144 186 PFTB 1 REPEAT 193 234 PFTB 2 REPEAT 245 284 PFTB 3 REPEAT 291 333 PFTB 4	"Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to a cysteine at the fourth position from the C-terminus of proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X Known substrates include RAC1, RAC2, RAP1A and RAP1B"
4	P53611	Geranylgeranyl transferase type-2 subunit beta	331	REPEAT 20 61 PFTB 1 REPEAT 68 109 PFTB 2 REPEAT 116 157 PFTB 3 REPEAT 164 205 PFTB 4 REPEAT 212 253 PFTB 5 REPEAT 260 302 PFTB 6	"Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A"