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O00629 Proteins with ARM Repeats

Uniprot ID: O00629	Protein name : Importin subunit alpha-3	Gene : KPNA4 QIP1
Protein Families : Importin alpha family	Squence Length : 521

Sequence	>O00629 522 MADNEKLDNQRLKNFKNKGRDLETMRRQRNEVVVELRKNKRDEHLLKRRNVPHEDICEDSDIDGDYRVQNTSLEAIVQNASSDNQGIQLSAVQAARKLLSSDRNPPIDDLIKSGILPILVHCLERDDNPSLQFEAAWALTNIASGTSEQTQAVVQSNAVPLFLRLLHSPHQNVCEQAVWALGNIIGDGPQCRDYVISLGVVKPLLSFISPSIPITFLRNVTWVMVNLCRHKDPPPPMETIQEILPALCVLIHHTDVNILVDTVWALSYLTDAGNEQIQMVIDSGIVPHLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQVVLNCDALSHFPALLTHPKEKINKEAVWFLSNITAGNQQQVQAVIDANLVPMIIHLLDKGDFGTQKEAAWAISNLTISGRKDQVAYLIQQNVIPPFCNLLTVKDAQVVQVVLDGLSNILKMAEDEAETIGNLIEECGGLEKIEQLQNHENEDIYKLAYEIIDQFFSSDDIDEDPSLVPEAIQGGTFGFNSSANVPTEGFQF
Repeat regions	REPEAT 66 106 ARM 1 REPEAT 107 149 ARM 2 REPEAT 150 194 ARM 3 REPEAT 195 233 ARM 4 REPEAT 234 278 ARM 5 REPEAT 279 318 ARM 6 REPEAT 319 360 ARM 7 REPEAT 361 400 ARM 8 REPEAT 401 443 ARM 9 REPEAT 447 485 ARM 10 atypical
Sequence region of repeats	66- 106 VQNTSLEAIVQNASSDNQGIQLSAVQAARKLLSSDRNPPID 107- 149 DLIKSGILPILVHCLERDDNPSLQFEAAWALTNIASGTSEQTQ 150- 194 AVVQSNAVPLFLRLLHSPHQNVCEQAVWALGNIIGDGPQCRDYVI 195- 233 SLGVVKPLLSFISPSIPITFLRNVTWVMVNLCRHKDPPP 234- 278 PMETIQEILPALCVLIHHTDVNILVDTVWALSYLTDAGNEQIQMV 279- 318 IDSGIVPHLVPLLSHQEVKVQTAALRAVGNIVTGTDEQTQ 319- 360 VVLNCDALSHFPALLTHPKEKINKEAVWFLSNITAGNQQQVQ 361- 400 AVIDANLVPMIIHLLDKGDFGTQKEAAWAISNLTISGRKD 401- 443 QVAYLIQQNVIPPFCNLLTVKDAQVVQVVLDGLSNILKMAEDE 447- 485 IGNLIEECGGLEKIEQLQNHENEDIYKLAYEIIDQFFSS
Domains	DOMAIN 2 58 IBB
Function	"Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS"
Motifs	MOTIF 43 52 Nuclear localization signal