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O14727 Proteins with WD Repeats
Uniprot ID: O14727
Protein name : Apoptotic protease-activating factor 1
Gene : APAF1 KIAA0413
Protein Families :
Squence Length : 1248
Sequence
>O14727 1249 MDAKARNCLLQHREALEKDIKTSYIMDHMISDGFLTISEEEKVRNEPTQQQRAAMLIKMILKKDNDSYVSFYNALLHEGYKDLAALLHDGIPVVSSSSGKDSVSGITSYVRTVLCEGGVPQRPVVFVTRKKLVNAIQQKLSKLKGEPGWVTIHGMAGCGKSVLAAEAVRDHSLLEGCFPGGVHWVSVGKQDKSGLLMKLQNLCTRLDQDESFSQRLPLNIEEAKDRLRILMLRKHPRSLLILDDVWDSWVLKAFDSQCQILLTTRDKSVTDSVMGPKYVVPVESSLGKEKGLEILSLFVNMKKADLPEQAHSIIKECKGSPLVVSLIGALLRDFPNRWEYYLKQLQNKQFKRIRKSSSYDYEALDEAMSISVEMLREDIKDYYTDLSILQKDVKVPTKVLCILWDMETEEVEDILQEFVNKSLLFCDRNGKSFRYYLHDLQVDFLTEKNCSQLQDLHKKIITQFQRYHQPHTLSPDQEDCMYWYNFLAYHMASAKMHKELCALMFSLDWIKAKTELVGPAHLIHEFVEYRHILDEKDCAVSENFQEFLSLNGHLLGRQPFPNIVQLGLCEPETSEVYQQAKLQAKQEVDNGMLYLEWINKKNITNLSRLVVRPHTDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIKAHEDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYDEHSEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMFGHTNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSINVKQFFLNLEDPQEDMEVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTGHHSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCRGHLSWVHGVMFSPDGSSFLTSSDDQTIRLWETKKVCKNSAVMLKQEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLTEAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRFQHKKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRGHQETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFVCHQGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELRGHNGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCAPLSEEGAATHGGWVTDLCFSPDGKMLISAGGYIKWWNVVTGESSQTFYTNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE
Repeat regions
REPEAT 613 652 WD 1-1 REPEAT 655 694 WD 1-2 REPEAT 697 738 WD 1-3 REPEAT 741 780 WD 1-4 REPEAT 796 836 WD 1-5 REPEAT 838 877 WD 1-6 REPEAT 880 910 WD 1-7 REPEAT 922 958 WD 2-1 REPEAT 959 998 WD 2-2 REPEAT 1001 1040 WD 2-3 REPEAT 1042 1080 WD 2-4 REPEAT 1083 1122 WD 2-5 REPEAT 1125 1164 WD 2-6 REPEAT 1175 1212 WD 2-7 REPEAT 1213 1248 WD 2-8
Sequence region of repeats
613- 652 TDAVYHACFSEDGQRIASCGADKTLQVFKAETGEKLLEIK 655- 694 EDEVLCCAFSTDDRFIATCSVDKKVKIWNSMTGELVHTYD 697- 738 SEQVNCCHFTNSSHHLLLATGSSDCFLKLWDLNQKECRNTMF 741- 780 TNSVNHCRFSPDDKLLASCSADGTLKLWDATSANERKSIN 796- 836 EVIVKCCSWSADGARIMVAAKNKIFLFDIHTSGLLGEIHTG 838- 877 HSTIQYCDFSPQNHLAVVALSQYCVELWNTDSRSKVADCR 880- 910 LSWVHGVMFSPDGSSFLTSSDDQTIRLWETK 922- 958 QEVDVVFQENEVMVLAVDHIRRLQLINGRTGQIDYLT 959- 998 EAQVSCCCLSPHLQYIAFGDENGAIEILELVNNRIFQSRF 1001- 1040 KKTVWHIQFTADEKTLISSSDDAEIQVWNWQLDKCIFLRG 1042- 1080 QETVKDFRLLKNSRLLSWSFDGTVKVWNIITGNKEKDFV 1083- 1122 QGTVLSCDISHDATKFSSTSADKTAKIWSFDLLLPLHELR 1125- 1164 NGCVRCSAFSVDSTLLATGDDNGEIRIWNVSNGELLHLCA 1175- 1212 GGWVTDLCFSPDGKMLISAGGYIKWWNVVTGESSQTFY 1213- 1248 TNGTNLKKIHVSPDFKTYVTVDNLGILYILQTLE
Domains
DOMAIN 1 90 CARD. DOMAIN 104 415 NB-ARC
Function
"Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis"
Binding Site
BINDING 265 265 ATP
Nucleotide Binding
NP_BIND 154 161 ATP
Mutation
160 160 K->R: No association with APAF-1 368 368 M->L: Activation of pro-caspase-9 independent of cytochrome c