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O14879 Proteins with TPR Repeats
Uniprot ID: O14879
Protein name : Interferon-induced protein with tetratricopeptide repeats 3
Gene : IFIT3 CIG-49 IFI60 IFIT4 ISG60
Protein Families : IFIT family
Squence Length : 490
Sequence
>O14879 491 MSEVTKNSLEKILPQLKCHFTWNLFKEDSVSRDLEDRVCNQIEFLNTEFKATMYNLLAYIKHLDGNNEAALECLRQAEELIQQEHADQAEIRSLVTWGNYAWVYYHLGRLSDAQIYVDKVKQTCKKFSNPYSIEYSELDCEEGWTQLKCGRNERAKVCFEKALEEKPNNPEFSSGLAIAMYHLDNHPEKQFSTDVLKQAIELSPDNQYVKVLLGLKLQKMNKEAEGEQFVEEALEKSPCQTDVLRSAAKFYRRKGDLDKAIELFQRVLESTPNNGYLYHQIGCCYKAKVRQMQNTGESEASGNKEMIEALKQYAMDYSNKALEKGLNPLNAYSDLAEFLETECYQTPFNKEVPDAEKQQSHQRYCNLQKYNGKSEDTAVQHGLEGLSISKKSTDKEEIKDQPQNVSENLLPQNAPNYWYLQGLIHKQNGDLLQAAKCYEKELGRLLRDAPSGIGSIFLSASELEDGSEEMGQGAVSSSPRELLSNSEQLN
Repeat regions
REPEAT 51 84 TPR 1 REPEAT 94 127 TPR 2 REPEAT 136 169 TPR 3 REPEAT 172 206 TPR 4 REPEAT 207 240 TPR 5 REPEAT 241 274 TPR 6 REPEAT 415 448 TPR 7 REPEAT 450 481 TPR 8
Sequence region of repeats
51- 84 MYNLLAYIKHLDGNNEAALECLRQAEELIQQEHA 94- 127 TWGNYAWVYYHLGRLSDAQIYVDKVKQTCKKFSN 136- 169 LDCEEGWTQLKCGRNERAKVCFEKALEEKPNNPE 172- 206 SGLAIAMYHLDNHPEKQFSTDVLKQAIELSPDNQY 207- 240 VKVLLGLKLQKMNKEAEGEQFVEEALEKSPCQTD 241- 274 VLRSAAKFYRRKGDLDKAIELFQRVLESTPNNGY 415- 448 YWYLQGLIHKQNGDLLQAAKCYEKELGRLLRDAP 450- 481 GIGSIFLSASELEDGSEEMGQGAVSSSPRELL
Function
"IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exihibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin-dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Upregulates CDKN1A/p21 by downregulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2"