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O15143 Proteins with WD Repeats
Uniprot ID: O15143
Protein name : Actin-related protein 2/3 complex subunit 1B
Gene : ARPC1B ARC41
Protein Families : WD repeat ARPC1 family
Squence Length : 372
Sequence
>O15143 373 MAYHSFLVEPISCHAWNKDRTQIAICPNNHEVHIYEKSGAKWTKVHELKEHNGQVTGIDWAPESNRIVTCGTDRNAYVWTLKGRTWKPTLVILRINRAARCVRWAPNENKFAVGSGSRVISICYFEQENDWWVCKHIKKPIRSTVLSLDWHPNNVLLAAGSCDFKCRIFSAYIKEVEERPAPTPWGSKMPFGELMFESSSSCGWVHGVCFSASGSRVAWVSHDSTVCLADADKKMAVATLASETLPLLALTFITDNSLVAAGHDCFPVLFTYDAAAGMLSFGGRLDVPKQSSQRGLTARERFQNLDKKASSEGGTAAGAGLDSLHKNSVSQISVLSGGKAKCSQFCTTGMDGGMSIWDVKSLESALKDLKIK
Repeat regions
REPEAT 6 45 WD 1 REPEAT 50 89 WD 2 REPEAT 94 135 WD 3 REPEAT 140 179 WD 4 REPEAT 242 280 WD 5 REPEAT 324 367 WD 6
Sequence region of repeats
6- 45 VEPISCHAWNKDRTQIAICPNNHEVHIYEKSGAKWTKVHE 50- 89 NGQVTGIDWAPESNRIVTCGTDRNAYVWTLKGRTWKPTLV 94- 135 NRAARCVRWAPNENKFAVGSGSRVISICYFEQENDWWVCKHI 140- 179 RSTVLSLDWHPNNVLLAAGSCDFKCRIFSAYIKEVEERPA 242- 280 TLPLLALTFITDNSLVAAGHDCFPVLFTYDAAAGMLSFG 324- 367 KNSVSQISVLSGGKAKCSQFCTTGMDGGMSIWDVKSLESALKDL
Function
Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks
Disease
"DISEASE: Platelet abnormalities with eosinophilia and immune-mediated inflammatory disease (PLTEID) [MIM:617718]: An autosomal recessive disorder characterized by platelet abnormalities, vasculitis, eosinophilia, and predisposition to inflammatory diseases Note=The disease is caused by mutations affecting the gene represented in this entry"