BACK
HOME
O60336 Proteins with WD Repeats
Uniprot ID: O60336
Protein name : Mitogen-activated protein kinase-binding protein 1
Gene : MAPKBP1 JNKBP1 KIAA0596
Protein Families :
Squence Length : 1514
Sequence
>O60336 1515 MAVEGSTITSRIKNLLRSPSIKLRRSKAGNRREDLSSKVTLEKVLGITVSGGRGLACDPRSGLVAYPAGCVVVLFNPRKHKQHHILNSSRKTITALAFSPDGKYLVTGESGHMPAVRVWDVAEHSQVAELQEHKYGVACVAFSPSAKYIVSVGYQHDMIVNVWAWKKNIVVASNKVSSRVTAVSFSEDCSYFVTAGNRHIKFWYLDDSKTSKVNATVPLLGRSGLLGELRNNLFTDVACGRGKKADSTFCITSSGLLCEFSDRRLLDKWVELRNIDSFTTTVAHCISVSQDYIFCGCADGTVRLFNPSNLHFLSTLPRPHALGTDIASVTEASRLFSGVANARYPDTIALTFDPTNQWLSCVYNDHSIYVWDVRDPKKVGKVYSALYHSSCVWSVEVYPEVKDSNQACLPPSSFITCSSDNTIRLWNTESSGVHGSTLHRNILSSDLIKIIYVDGNTQALLDTELPGGDKADASLLDPRVGIRSVCVSPNGQHLASGDRMGTLRVHELQSLSEMLKVEAHDSEILCLEYSKPDTGLKLLASASRDRLIHVLDAGREYSLQQTLDEHSSSITAVKFAASDGQVRMISCGADKSIYFRTAQKSGDGVQFTRTHHVVRKTTLYDMDVEPSWKYTAIGCQDRNIRIFNISSGKQKKLFKGSQGEDGTLIKVQTDPSGIYIATSCSDKNLSIFDFSSGECVATMFGHSEIVTGMKFSNDCKHLISVSGDSCIFVWRLSSEMTISMRQRLAELRQRQRGGKQQGPSSPQRASGPNRHQAPSMLSPGPALSSDSDKEGEDEGTEEELPALPVLAKSTKKALASVPSPALPRSLSHWEMSRAQESVGFLDPAPAANPGPRRRGRWVQPGVELSVRSMLDLRQLETLAPSLQDPSQDSLAIIPSGPRKHGQEALETSLTSQNEKPPRPQASQPCSYPHIIRLLSQEEGVFAQDLEPAPIEDGIVYPEPSDNPTMDTSEFQVQAPARGTLGRVYPGSRSSEKHSPDSACSVDYSSSCLSSPEHPTEDSESTEPLSVDGISSDLEEPAEGDEEEEEEEGGMGPYGLQEGSPQTPDQEQFLKQHFETLASGAAPGAPVQVPERSESRSISSRFLLQVQTRPLREPSPSSSSLALMSRPAQVPQASGEQPRGNGANPPGAPPEVEPSSGNPSPQQAASVLLPRCRLNPDSSWAPKRVATASPFSGLQKAQSVHSLVPQERHEASLQAPSPGALLSREIEAQDGLGSLPPADGRPSRPHSYQNPTTSSMAKISRSISVGENLGLVAEPQAHAPIRVSPLSKLALPSRAHLVLDIPKPLPDRPTLAAFSPVTKGRAPGEAEKPGFPVGLGKAHSTTERWACLGEGTTPKPRTECQAHPGPSSPCAQQLPVSSLFQGPENLQPPPPEKTPNPMECTKPGAALSQDSEPAVSLEQCEQLVAELRGSVRQAVRLYHSVAGCKMPSAEQSRIAQLLRDTFSSVRQELEAVAGAVLSSPGSSPGAVGAEQTQALLEQYSELLLRAVERRMERKL
Repeat regions
REPEAT 88 129 WD 1 REPEAT 132 173 WD 2 REPEAT 175 213 WD 3 REPEAT 276 315 WD 4 REPEAT 342 381 WD 5 REPEAT 387 436 WD 6 REPEAT 477 516 WD 7 REPEAT 519 561 WD 8 REPEAT 565 606 WD 9 REPEAT 614 653 WD 10 REPEAT 659 698 WD 11 REPEAT 701 740 WD 12
Sequence region of repeats
88- 129 RKTITALAFSPDGKYLVTGESGHMPAVRVWDVAEHSQVAELQ 132- 173 KYGVACVAFSPSAKYIVSVGYQHDMIVNVWAWKKNIVVASNK 175- 213 SSRVTAVSFSEDCSYFVTAGNRHIKFWYLDDSKTSKVNA 276- 315 FTTTVAHCISVSQDYIFCGCADGTVRLFNPSNLHFLSTLP 342- 381 YPDTIALTFDPTNQWLSCVYNDHSIYVWDVRDPKKVGKVY 387- 436 SSCVWSVEVYPEVKDSNQACLPPSSFITCSSDNTIRLWNTESSGVHGSTL 477- 516 RVGIRSVCVSPNGQHLASGDRMGTLRVHELQSLSEMLKVE 519- 561 DSEILCLEYSKPDTGLKLLASASRDRLIHVLDAGREYSLQQTL 565- 606 SSSITAVKFAASDGQVRMISCGADKSIYFRTAQKSGDGVQFT 614- 653 KTTLYDMDVEPSWKYTAIGCQDRNIRIFNISSGKQKKLFK 659- 698 DGTLIKVQTDPSGIYIATSCSDKNLSIFDFSSGECVATMF 701- 740 SEIVTGMKFSNDCKHLISVSGDSCIFVWRLSSEMTISMRQ
Function
"Negative regulator of NOD2 function. It down-regulates NOD2-induced processes such as activation of NF-kappa-B signaling, IL8 secretion and antibacterial response (PubMed:22700971). Involved in JNK signaling pathway (By similarity)"
Disease
"DISEASE: Nephronophthisis 20 (NPHP20) [MIM:617271]: A form of nephronophthisis, an autosomal recessive chronic tubulo-interstitial nephritis that progresses to end-stage renal failure Some patients have cystic kidneys of normal size and no extrarenal manifestations, whereas others have enlarged renal size and severe extrarenal defects, including hypertrophic obstructive cardiomyopathy, aortic stenosis, pulmonary stenosis, patent ductus arteriosus, situs inversus, and periportal liver fibrosis NPHP20 patients do not show extrarenal manifestations or evidence of a ciliopathy, such as situs inversus or polydactyly Note=The disease is caused by mutations affecting the gene represented in this entry"