Uniprot ID: O60603	Protein name : Toll-like receptor 2	Gene : TLR2 TIL4
Protein Families : Toll-like receptor family	Squence Length : 784

Sequence	>O60603 785 MPHTLWMVWVLGVIISLSKEESSNQASLSCDRNGICKGSSGSLNSIPSGLTEAVKSLDLSNNRITYISNSDLQRCVNLQALVLTSNGINTIEEDSFSSLGSLEHLDLSYNYLSNLSSSWFKPLSSLTFLNLLGNPYKTLGETSLFSHLTKLQILRVGNMDTFTKIQRKDFAGLTFLEELEIDASDLQSYEPKSLKSIQNVSHLILHMKQHILLLEIFVDVTSSVECLELRDTDLDTFHFSELSTGETNSLIKKFTFRNVKITDESLFQVMKLLNQISGLLELEFDDCTLNGVGNFRASDNDRVIDPGKVETLTIRRLHIPRFYLFYDLSTLYSLTERVKRITVENSKVFLVPCLLSQHLKSLEYLDLSENLMVEEYLKNSACEDAWPSLQTLILRQNHLASLEKTGETLLTLKNLTNIDISKNSFHSMPETCQWPEKMKYLNLSSTRIHSVTGCIPKTLEILDVSNNNLNLFSLNLPQLKELYISRNKLMTLPDASLLPMLLVLKISRNAITTFSKEQLDSFHTLKTLEAGGNNFICSCEFLSFTQEQQALAKVLIDWPANYLCDSPSHVRGQQVQDVRLSVSECHRTALVSGMCCALFLLILLTGVLCHRFHGLWYMKMMWAWLQAKRKPRKAPSRNICYDAFVSYSERDAYWVENLMVQELENFNPPFKLCLHKRDFIPGKWIIDNIIDSIEKSHKTVFVLSENFVKSEWCKYELDFSHFRLFDENNDAAILILLEPIEKKAIPQRFCKLRKIMNTKTYLEWPMDEAQREGFWVNLRAAIKS
Repeat regions	REPEAT 54 77 LRR 1 REPEAT 78 101 LRR 2 REPEAT 102 125 LRR 3 REPEAT 126 150 LRR 4 REPEAT 151 175 LRR 5 REPEAT 176 199 LRR 6 REPEAT 200 223 LRR 7 REPEAT 224 250 LRR 8 REPEAT 251 278 LRR 9 REPEAT 279 308 LRR 10 REPEAT 309 337 LRR 11 REPEAT 338 361 LRR 12 REPEAT 362 388 LRR 13 REPEAT 389 414 LRR 14 REPEAT 415 437 LRR 15 REPEAT 438 457 LRR 16 REPEAT 458 478 LRR 17 REPEAT 479 500 LRR 18 REPEAT 501 524 LRR 19
Sequence region of repeats	54- 77 SLDLSNNRITYISNSDLQRCVNLQ 78- 101 ALVLTSNGINTIEEDSFSSLGSLE 102- 125 HLDLSYNYLSNLSSSWFKPLSSLT 126- 150 FLNLLGNPYKTLGETSLFSHLTKLQ 151- 175 ILRVGNMDTFTKIQRKDFAGLTFLE 176- 199 ELEIDASDLQSYEPKSLKSIQNVS 200- 223 HLILHMKQHILLLEIFVDVTSSVE 224- 250 CLELRDTDLDTFHFSELSTGETNSLIK 251- 278 KFTFRNVKITDESLFQVMKLLNQISGLL 279- 308 ELEFDDCTLNGVGNFRASDNDRVIDPGKVE 309- 337 TLTIRRLHIPRFYLFYDLSTLYSLTERVK 338- 361 RITVENSKVFLVPCLLSQHLKSLE 362- 388 YLDLSENLMVEEYLKNSACEDAWPSLQ 389- 414 TLILRQNHLASLEKTGETLLTLKNLT 415- 437 NIDISKNSFHSMPETCQWPEKMK 438- 457 YLNLSSTRIHSVTGCIPKTL 458- 478 EILDVSNNNLNLFSLNLPQLK 479- 500 ELYISRNKLMTLPDASLLPMLL 501- 524 VLKISRNAITTFSKEQLDSFHTLK
Domains	DOMAIN 525 579 LRRCT. DOMAIN 639 784 TIR
Function	"Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides (PubMed:21078852, PubMed:17889651). Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. May also activate immune cells and promote apoptosis in response to the lipid moiety of lipoproteins (PubMed:10426995, PubMed:10426996). Recognizes mycoplasmal macrophage-activating lipopeptide-2kD (MALP-2), soluble tuberculosis factor (STF), phenol-soluble modulin (PSM) and B.burgdorferi outer surface protein A lipoprotein (OspA-L) cooperatively with TLR6 (PubMed:11441107). Stimulation of monocytes in vitro with M.tuberculosis PstS1 induces p38 MAPK and ERK1/2 activation primarily via this receptor, but also partially via TLR4 (PubMed:16622205). MAPK activation in response to bacterial peptidoglycan also occurs via this receptor (PubMed:16622205). Acts as a receptor for M.tuberculosis lipoproteins LprA, LprG, LpqH and PstS1, some lipoproteins are dependent on other coreceptors (TLR1, CD14 and/or CD36); the lipoproteins act as agonists to modulate antigen presenting cell functions in response to the pathogen (PubMed:19362712). M.tuberculosis HSP70 (dnaK) but not HSP65 (groEL-2) acts via this protein to stimulate NF-kappa-B expression (PubMed:15809303). Recognizes M.tuberculosis major T-antigen EsxA (ESAT-6) which inhibits downstream MYD88-dependent signaling (shown in mouse) (By similarity). Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway. Forms the cluster TLR2:TLR6:CD14:CD36 in response to diacylated lipopeptides and TLR2:TLR1:CD14 in response to triacylated lipopeptides (PubMed:16880211). Required for normal uptake of M.tuberculosis, a process that is inhibited by M.tuberculosis LppM (By similarity)"
Motifs	MOTIF 761 778 ATG16L1-binding motif
Mutation	114 114 N->S: Prevents addition of N-glycans 199 199 N->D: Prevents addition of N-glycans 416 416 T->A: Prevents addition of N-glycans 442 442 N->D: Prevents addition of N-glycans 681 681 P->F: Abolishes the interaction with MYD88 709 709 K->R: Reduced protein stability 714 714 K->R: Reduced protein stability 742 743 KK->RR: Reduced protein stability 751 751 K->R: Reduced protein stability 754 754 K->R: Loss of PPP1R11-mediated ubiquitination and degradation

O60603 Proteins with LRR Repeats