BACK HOME

O60882 Proteins with Hemopexin Repeats

Uniprot ID: O60882	Protein name : Matrix metalloproteinase-20	Gene : MMP20
Protein Families : Peptidase M10A family	Squence Length : 483

Sequence	>O60882 484 MKVLPASGLAVFLIMALKFSTAAPSLVAASPRTWRNNYRLAQAYLDKYYTNKEGHQIGEMVARGSNSMIRKIKELQAFFGLQVTGKLDQTTMNVIKKPRCGVPDVANYRLFPGEPKWKKNTLTYRISKYTPSMSSVEVDKAVEMALQAWSSAVPLSFVRINSGEADIMISFENGDHGDSYPFDGPRGTLAHAFAPGEGLGGDTHFDNAEKWTMGTNGFNLFTVAAHEFGHALGLAHSTDPSALMYPTYKYKNPYGFHLPKDDVKGIQALYGPRKVFLGKPTLPHAPHHKPSIPDLCDSSSSFDAVTMLGKELLLFKDRIFWRRQVHLRTGIRPSTITSSFPQLMSNVDAAYEVAERGTAYFFKGPHYWITRGFQMQGPPRTIYDFGFPRHVQQIDAAVYLREPQKTLFFVGDEYYSYDERKRKMEKDYPKNTEEEFSGVNGQIDAAVELNGYIYFFSGPKTYKYDTEKEDVVSVVKSSSWIGC
Repeat regions	REPEAT 293 343 Hemopexin 1 REPEAT 344 389 Hemopexin 2 REPEAT 391 439 Hemopexin 3 REPEAT 440 483 Hemopexin 4
Sequence region of repeats	293- 343 LCDSSSSFDAVTMLGKELLLFKDRIFWRRQVHLRTGIRPSTITSSFPQLMS 344- 389 NVDAAYEVAERGTAYFFKGPHYWITRGFQMQGPPRTIYDFGFPRHV 391- 439 QIDAAVYLREPQKTLFFVGDEYYSYDERKRKMEKDYPKNTEEEFSGVNG 440- 483 QIDAAVELNGYIYFFSGPKTYKYDTEKEDVVSVVKSSSWIGC
Function	"Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation. Cleaves aggrecan at the '360-Asn-\|-Phe-361' site"
Active Site	ACT_SITE 227 227
Motifs	MOTIF 98 105 Cysteine switch
Disease	"DISEASE: Amelogenesis imperfecta, hypomaturation type, 2A2 (AI2A2) [MIM:612529]: A defect of enamel formation The disorder involves both primary and secondary dentitions The teeth have a shiny agar jelly appearance and the enamel is softer than normal Brown pigment is present in middle layers of enamel Note=The disease is caused by mutations affecting the gene represented in this entry"