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O60907 Proteins with WD Repeats
Uniprot ID: O60907
Protein name : F-box-like/WD repeat-containing protein TBL1X
Gene : TBL1X TBL1
Protein Families : WD repeat EBI family
Squence Length : 577
Sequence
>O60907 578 MTELAGASSSCCHRPAGRGAMQSVLHHFQRLRGREGGSHFINTSSPRGEAKMSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPAALISILQKGLQYVEAEISINEDGTVFDGRPIESLSLIDAVMPDVVQTRQQAFREKLAQQQASAAAAAAAATAAATAATTTSAGVSHQNPSKNREATVNGEENRAHSVNNHAKPMEIDGEVEIPSSKATVLRGHESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQHKGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFPFHSAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGHTNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQAHNKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLTKHQEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYRGTGGIFEVCWNARGDKVGASASDGSVCVLDLRK
Repeat regions
REPEAT 230 269 WD 1 REPEAT 286 325 WD 2 REPEAT 327 366 WD 3 REPEAT 369 409 WD 4 REPEAT 410 449 WD 5 REPEAT 452 500 WD 6 REPEAT 503 542 WD 7 REPEAT 544 576 WD 8
Sequence region of repeats
230- 269 ESEVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQ 286- 325 NKDVTSLDWNTNGTLLATGSYDGFARIWTEDGNLASTLGQ 327- 366 KGPIFALKWNRKGNYILSAGVDKTTIIWDAHTGEAKQQFP 369- 409 SAPALDVDWQNNTTFASCSTDMCIHVCRLGCDRPVKTFQGH 410- 449 TNEVNAIKWDPSGMLLASCSDDMTLKIWSMKQEVCIHDLQ 452- 500 NKEIYTIKWSPTGPATSNPNSNIMLASASFDSTVRLWDIERGVCTHTLT 503- 542 QEPVYSVAFSPDGKYLASGSFDKCVHIWNTQSGNLVHSYR 544- 576 TGGIFEVCWNARGDKVGASASDGSVCVLDLRK
Domains
DOMAIN 55 87 LisH. DOMAIN 92 137 F-box-like
Function
"F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units (PubMed:14980219). Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of corepressor complexes that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of transcription repressor complexes, thereby allowing cofactor exchange (PubMed:21240272)"
Mutation
"77 77 F->A: Abolished homotetramerization, leading to a homodimer 90 90 I->A: Reduced interaction with NCOR2 and GPS2 94 94 L->A,E: Does not affect interaction with NCOR2 and GPS2 96 96 P->G: Does not affect interaction with NCOR2 and GPS2 108 108 L->A,Q: Reduced interaction with NCOR2 and GPS2 111 111 V->N,Q: Reduced interaction with NCOR2 and GPS2 117 117 I->A: Does not affect interaction with NCOR2 and GPS2"