Uniprot ID: O75762	Protein name : Transient receptor potential cation channel subfamily A member 1	Gene : TRPA1 ANKTM1
Protein Families : Transient receptor (TC 1.A.4) family	Squence Length : 1119

Sequence	>O75762 1120 MKRSLRKMWRPGEKKEPQGVVYEDVPDDTEDFKESLKVVFEGSAYGLQNFNKQKKLKRCDDMDTFFLHYAAAEGQIELMEKITRDSSLEVLHEMDDYGNTPLHCAVEKNQIESVKFLLSRGANPNLRNFNMMAPLHIAVQGMNNEVMKVLLEHRTIDVNLEGENGNTAVIIACTTNNSEALQILLKKGAKPCKSNKWGCFPIHQAAFSGSKECMEIILRFGEEHGYSRQLHINFMNNGKATPLHLAVQNGDLEMIKMCLDNGAQIDPVEKGRCTAIHFAATQGATEIVKLMISSYSGSVDIVNTTDGCHETMLHRASLFDHHELADYLISVGADINKIDSEGRSPLILATASASWNIVNLLLSKGAQVDIKDNFGRNFLHLTVQQPYGLKNLRPEFMQMQQIKELVMDEDNDGCTPLHYACRQGGPGSVNNLLGFNVSIHSKSKDKKSPLHFAASYGRINTCQRLLQDISDTRLLNEGDLHGMTPLHLAAKNGHDKVVQLLLKKGALFLSDHNGWTALHHASMGGYTQTMKVILDTNLKCTDRLDEDGNTALHFAAREGHAKAVALLLSHNADIVLNKQQASFLHLALHNKRKEVVLTIIRSKRWDECLKIFSHNSPGNKCPITEMIEYLPECMKVLLDFCMLHSTEDKSCRDYYIEYNFKYLQCPLEFTKKTPTQDVIYEPLTALNAMVQNNRIELLNHPVCKEYLLMKWLAYGFRAHMMNLGSYCLGLIPMTILVVNIKPGMAFNSTGIINETSDHSEILDTTNSYLIKTCMILVFLSSIFGYCKEAGQIFQQKRNYFMDISNVLEWIIYTTGIIFVLPLFVEIPAHLQWQCGAIAVYFYWMNFLLYLQRFENCGIFIVMLEVILKTLLRSTVVFIFLLLAFGLSFYILLNLQDPFSSPLLSIIQTFSMMLGDINYRESFLEPYLRNELAHPVLSFAQLVSFTIFVPIVLMNLLIGLAVGDIAEVQKHASLKRIAMQVELHTSLEKKLPLWFLRKVDQKSTIVYPNKPRSGGMLFHIFCFLFCTGEIRQEIPNADKSLEMEILKQKYRLKDLTFLLEKQHELIKLIIQKMEIISETEDDDSHCSFQDRFKKEQMEQRNSRWNTVLRAVKAKTHHLEP
Repeat regions	REPEAT 62 92 ANK 1 REPEAT 97 126 ANK 2 REPEAT 130 160 ANK 3 REPEAT 164 193 ANK 4 REPEAT 197 226 ANK 5 REPEAT 238 267 ANK 6 REPEAT 271 301 ANK 7 REPEAT 308 337 ANK 8 REPEAT 341 370 ANK 9 REPEAT 374 403 ANK 10 REPEAT 412 441 ANK 11 REPEAT 445 474 ANK 12 REPEAT 481 510 ANK 13 REPEAT 513 542 ANK 14 REPEAT 547 576 ANK 15 REPEAT 579 609 ANK 16
Sequence region of repeats	62- 92 TFFLHYAAAEGQIELMEKITRDSSLEVLHEM 97- 126 NTPLHCAVEKNQIESVKFLLSRGANPNLRN 130- 160 MAPLHIAVQGMNNEVMKVLLEHRTIDVNLEG 164- 193 NTAVIIACTTNNSEALQILLKKGAKPCKSN 197- 226 CFPIHQAAFSGSKECMEIILRFGEEHGYSR 238- 267 ATPLHLAVQNGDLEMIKMCLDNGAQIDPVE 271- 301 CTAIHFAATQGATEIVKLMISSYSGSVDIVN 308- 337 ETMLHRASLFDHHELADYLISVGADINKID 341- 370 RSPLILATASASWNIVNLLLSKGAQVDIKD 374- 403 RNFLHLTVQQPYGLKNLRPEFMQMQQIKEL 412- 441 CTPLHYACRQGGPGSVNNLLGFNVSIHSKS 445- 474 KSPLHFAASYGRINTCQRLLQDISDTRLLN 481- 510 MTPLHLAAKNGHDKVVQLLLKKGALFLSDH 513- 542 WTALHHASMGGYTQTMKVILDTNLKCTDRL 547- 576 NTALHFAAREGHAKAVALLLSHNADIVLNK 579- 609 ASFLHLALHNKRKEVVLTIIRSKRWDECLKI
Function	"Receptor-activated non-selective cation channel involved in detection of pain and possibly also in cold perception and inner ear function (PubMed:25389312, PubMed:25855297). Has a central role in the pain response to endogenous inflammatory mediators and to a diverse array of volatile irritants, such as mustard oil, cinnamaldehyde, garlic and acrolein, an irritant from tears gas and vehicule exhaust fumes (PubMed:25389312, PubMed:20547126). Is also activated by menthol (in vitro)(PubMed:25389312). Acts also as a ionotropic cannabinoid receptor by being activated by delta(9)-tetrahydrocannabinol (THC), the psychoactive component of marijuana (PubMed:25389312). May be a component for the mechanosensitive transduction channel of hair cells in inner ear, thereby participating in the perception of sounds. Probably operated by a phosphatidylinositol second messenger system (By similarity)"
Disease	"DISEASE: Episodic pain syndrome, familial, 1 (FEPS1) [MIM:615040]: An autosomal dominant neurologic disorder characterized by onset in infancy of episodic debilitating upper body pain triggered by fasting, cold, and physical stress The period of intense pain is accompanied by breathing difficulties, tachycardia, sweating, generalized pallor, peribuccal cyanosis, and stiffness of the abdominal wall Affected individuals do not manifest altered pain sensitivity outside the episodes Note=The disease is caused by mutations affecting the gene represented in this entry"

O75762 Proteins with ANK Repeats