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P30153 Proteins with HEAT Repeats

Uniprot ID: P30153	Protein name : Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform	Gene : PPP2R1A
Protein Families : Phosphatase 2A regulatory subunit A family	Squence Length : 589

Sequence	>P30153 590 MAAADGDDSLYPIAVLIDELRNEDVQLRLNSIKKLSTIALALGVERTRSELLPFLTDTIYDEDEVLLALAEQLGTFTTLVGGPEYVHCLLPPLESLATVEETVVRDKAVESLRAISHEHSPSDLEAHFVPLVKRLAGGDWFTSRTSACGLFSVCYPRVSSAVKAELRQYFRNLCSDDTPMVRRAAASKLGEFAKVLELDNVKSEIIPMFSNLASDEQDSVRLLAVEACVNIAQLLPQEDLEALVMPTLRQAAEDKSWRVRYMVADKFTELQKAVGPEITKTDLVPAFQNLMKDCEAEVRAAASHKVKEFCENLSADCRENVIMSQILPCIKELVSDANQHVKSALASVIMGLSPILGKDNTIEHLLPLFLAQLKDECPEVRLNIISNLDCVNEVIGIRQLSQSLLPAIVELAEDAKWRVRLAIIEYMPLLAGQLGVEFFDEKLNSLCMAWLVDHVYAIREAATSNLKKLVEKFGKEWAHATIIPKVLAMSGDPNYLHRMTTLFCINVLSEVCGQDITTKHMLPTVLRMAGDPVANVRFNVAKSLQKIGPILDNSTLQSEVKPILEKLTQDQDVDVKYFAQEALTVLSLA
Repeat regions	REPEAT 8 46 HEAT 1 REPEAT 47 84 HEAT 2 REPEAT 85 123 HEAT 3 REPEAT 124 161 HEAT 4 REPEAT 162 200 HEAT 5 REPEAT 201 239 HEAT 6 REPEAT 240 278 HEAT 7 REPEAT 279 321 HEAT 8 REPEAT 322 360 HEAT 9 REPEAT 361 399 HEAT 10 REPEAT 400 438 HEAT 11 REPEAT 439 477 HEAT 12 REPEAT 478 516 HEAT 13 REPEAT 517 555 HEAT 14 REPEAT 556 589 HEAT 15
Sequence region of repeats	8- 46 LYPIAVLIDELRNEDVQLRLNSIKKLSTIALALGVERTR 47- 84 SELLPFLTDTIYDEDEVLLALAEQLGTFTTLVGGPEYV 85- 123 HCLLPPLESLATVEETVVRDKAVESLRAISHEHSPSDLE 124- 161 AHFVPLVKRLAGGDWFTSRTSACGLFSVCYPRVSSAVK 162- 200 AELRQYFRNLCSDDTPMVRRAAASKLGEFAKVLELDNVK 201- 239 SEIIPMFSNLASDEQDSVRLLAVEACVNIAQLLPQEDLE 240- 278 ALVMPTLRQAAEDKSWRVRYMVADKFTELQKAVGPEITK 279- 321 TDLVPAFQNLMKDCEAEVRAAASHKVKEFCENLSADCRENVIM 322- 360 SQILPCIKELVSDANQHVKSALASVIMGLSPILGKDNTI 361- 399 EHLLPLFLAQLKDECPEVRLNIISNLDCVNEVIGIRQLS 400- 438 QSLLPAIVELAEDAKWRVRLAIIEYMPLLAGQLGVEFFD 439- 477 EKLNSLCMAWLVDHVYAIREAATSNLKKLVEKFGKEWAH 478- 516 ATIIPKVLAMSGDPNYLHRMTTLFCINVLSEVCGQDITT 517- 555 KHMLPTVLRMAGDPVANVRFNVAKSLQKIGPILDNSTLQ 556- 589 SEVKPILEKLTQDQDVDVKYFAQEALTVLSLA
Function	The PR65 subunit of protein phosphatase 2A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. Upon interaction with GNA12 promotes dephosphorylation of microtubule associated protein TAU/MAPT (PubMed:15525651). Required for proper chromosome segregation and for centromeric localization of SGO1 in mitosis (PubMed:16580887)
Disease	"DISEASE: Mental retardation, autosomal dominant 36 (MRD36) [MIM:616362]: A form of mental retardation, a disorder characterized by significantly below average general intellectual functioning associated with impairments in adaptive behavior and manifested during the developmental period Note=The disease is caused by mutations affecting the gene represented in this entry"